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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   Collaboration between PcG Proteins and MLL Fusions in Leukemogenesis: An Emerging Paradigm [作者：Zeisig, BB; Arteaga, MF; Thirant, C; So, CWE,期刊：Cancer Cell, 页码：551-553 , 文章类型： Editorial Material，,卷期：2011年20-5] PcG and TrxG proteins mostly with opposite transcriptional activities play key roles in normal and malignant development. In this issue of Cancer Cell, Tan et al. report an unexpected collaboration between CBX8 and MLL-A... Platelets Alter Tumor Cell Attributes to Propel Metastasis: Programming in Transit [作者：Gay, LJ; Felding-Habermann, B,期刊：Cancer Cell, 页码：553-554 , 文章类型： Editorial Material，,卷期：2011年20-5] Metastasis of epithelial tumors critically depends on acquisition of a disseminating phenotype that allows tumor cells to colonize distant organs. In this issue of Cancer Cell, Labelle et al. demonstrate that an epitheli... Power Cut: Inhibiting Mitochondrial Translation to Target Leukemia [作者：Jaras, M; Ebert, BL,期刊：Cancer Cell, 页码：555-556 , 文章类型： Editorial Material，,卷期：2011年20-5] In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic suscepti... The Two Faces of NF-kappa B Signaling in Cancer Development and Therapy [作者：Klein, U; Ghosh, S,期刊：Cancer Cell, 页码：556-558 , 文章类型： Editorial Material，,卷期：2011年20-5] Constitutive activation of NF-kappa B signaling can promote oncogenesis, providing a rationale for anticancer strategies that inhibit NF-kappa B signaling. Two recent publications in Genes & Development provide evidence ... Discovery of a Secreted Tumor Suppressor Provides a Promising Therapeutic Strategy for Follicular Lymphoma [作者：Mansour, MR; Look, AT,期刊：Cancer Cell, 页码：559-561 , 文章类型： Editorial Material，,卷期：2011年20-5] In a recent paper in Cell, Oricchio et al. identify EPHA7 as a tumor suppressor gene residing in the 6q-eleted region in follicular lymphoma. A truncated EPHA7(TR) isoform is secreted by normal B cells, inhibits EPHA2 si... CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis [作者：Tan, JY; Jones, M; Koseki, H; Nakayama, M; Muntean, AG; Maillard, I; Hess, JL,期刊：Cancer Cell, 页码：563-575 , 文章类型： Article，,卷期：2011年20-5] Chromosomal translocations involving the mixed lineage leukemia (MLL) gene lead to the development of acute leukemias. Constitutive HOX gene activation by MLL fusion proteins is required for MLL-mediated leukemogenesis; ... Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis [作者：Labelle, M; Begum, S; Hynes, RO,期刊：Cancer Cell, 页码：576-590 , 文章类型： Article，,卷期：2011年20-5] Interactions of cancer cells with the primary tumor microenvironment are important determinants of cancer progression toward metastasis but it is unknown whether additional prometastatic Signals are provided during the i... Altered Hematopoietic Cell Gene Expression Precedes Development of Therapy-Related Myelodysplasia/Acute Myeloid Leukemia and Identifies Patients at Risk [作者：Li, L; Li, M; Sun, CL; Francisco, L; Chakraborty, S; Sabado, M; McDonald, T; Gyorffy, J; Chang, KR; Wang, SR; Fan, WH; Li, JN; Zhao, LP; Radich, J; Forman, S; Bhatia, S; Bhatia, R,期刊：Cancer Cell, 页码：591-605 , 文章类型： Article，,卷期：2011年20-5] Therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) is a major complication of cancer treatment. We compared gene expression in CD34+ cells from patients who developed t-MDS/AML after autologous hematopo... Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands [作者：O'Hagan, HM; Wang, W; Sen, S; Shields, CD; Lee, SS; Zhang, YW; Clements, EG; Cai, Y; Van Neste, L; Easwaran, H; Casero, RA; Sears, CL; Baylin, SB,期刊：Cancer Cell, 页码：606-619 , 文章类型： Article，,卷期：2011年20-5] Cancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase 1 (DNMT1) to damaged chr... A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells [作者：Anders, L; Ke, N; Hydbring, P; Choi, YJ; Widlund, HR; Chick, JM; Zhai, HL; Vidal, M; Gygi, SP; Braun, P; Sicinski, P,期刊：Cancer Cell, 页码：620-634 , 文章类型： Article，,卷期：2011年20-5] Cyclin D-dependent kinases (CDK4 and CDK6) are positive regulators of cell cycle entry and they are over-active in the majority of human cancers. However, it is currently not completely understood by which cellular mecha... Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis [作者：Darido, C; Georgy, SR; Wilanowski, T; Dworkin, S; Auden, A; Zhao, Q; Rank, G; Srivastava, S; Finlay, MJ; Papenfuss, AT; Pandolfi, PP; Pearson, RB; Jane, SM,期刊：Cancer Cell, 页码：635-648 , 文章类型： Article，,卷期：2011年20-5] Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. Here, we identify the developmental transcription factor Grhl3 as a potent tumor suppressor of SCC in mice, and demo... The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis [作者：Zaki, MH; Vogel, P; Malireddi, RKS; Body-Malapel, M; Anand, PK; Bertin, J; Green, DR; Lamkanfi, M; Kanneganti, TD,期刊：Cancer Cell, 页码：649-660 , 文章类型： Article，,卷期：2011年20-5] NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been suggested to downregulate the production of inflammatory cytokines, but its physiological role in regulating inflammation has not been ... IL-6 Controls Leukemic Multipotent Progenitor Cell Fate and Contributes to Chronic Myelogenous Leukemia Development [作者：Reynaud, D; Pietras, E; Barry-Holson, K; Mir, A; Binnewies, M; Jeanne, M; Sala-Torra, O; Radich, JP; Passegue, E,期刊：Cancer Cell, 页码：661-673 , 文章类型： Article，,卷期：2011年20-5] Using a mouse model recapitulating the main features of human chronic myelogenous leukemia (CML), we uncover the hierarchy of leukemic stem and progenitor cells contributing to disease pathogenesis. We refine the charact... Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia [作者：Skrtic, M; Sriskanthadevan, S; Jhas, B; Gebbia, M; Wang, X; Wang, Z; Hurren, R; Jitkova, Y; Gronda, M; Maclean, N; Lai, CK; Eberhard, Y; Bartoszko, J; Spagnuolo, P; Rutledge, AC; Datti, A; Ketela, T; Moffat, J; Robinson, BH; Cameron, JH; Wrana, J; Eaves, CJ; Minden, MD; Wang, JCY; Dick, JE; Humphries, K; Nislow, C; Giaever, G; Schimmer, AD,期刊：Cancer Cell, 页码：674-688 , 文章类型： Article，,卷期：2011年20-5] To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome-wide screen in yeast identified mitochondri...