- ETV6-RUNX1 promotes survival of early B lineage progenitor cells via a dysregulated erythropoietin receptor
[作者：Torrano, V; Procter, J; Cardus, P; Greaves, M; Ford, AM,期刊：Blood, 页码：4910-4918 , 文章类型： Article，,卷期：2011年118-18]
- ETV6-RUNX1 gene fusion is usually an early, prenatal event in childhood acute lymphoblastic leukemia (ALL). Transformation results in the generation of a persistent (> 14 years) preleukemic clone, which postnatally conve...
- Dysregulated microRNAs affect pathways and targets of biologic relevance in nasal-type natural killer/T-cell lymphoma
[作者：Ng, SB; Yan, JL; Huang, GF; Selvarajan, V; Tay, JLS; Lin, BH; Bi, CL; Tan, J; Kwong, YL; Shimizu, N; Aozasa, K; Chng, WJ,期刊：Blood, 页码：4919-4929 , 文章类型： Article，,卷期：2011年118-18]
- We performed a comprehensive genome-wide miRNA expression profiling of extranodal nasal-type natural killer/T-cell lymphoma (NKTL) using formalin-fixed paraffin-embedded tissue (n = 30) and NK cell lines (n = 6) compared...
- Alteration of BIRC3 and multiple other NF-kappa B pathway genes in splenic marginal zone lymphoma
[作者：Rossi, D; Deaglio, S; Dominguez-Sola, D; Rasi, S; Vaisitti, T; Agostinelli, C; Spina, V; Bruscaggin, A; Monti, S; Cerri, M; Cresta, S; Fangazio, M; Arcaini, L; Lucioni, M; Marasca, R; Thieblemont, C; Capello, D; Facchetti, F; Kwee, I; Pileri, SA; Foa, R; Bertoni, F; Dalla-Favera, R; Pasqualucci, L; Gaidano, G,期刊：Blood, 页码：4930-4934 , 文章类型： Article，,卷期：2011年118-18]
- Splenic marginal zone lymphoma (SMZL) is one of the few B-cell lymphoma types that remain orphan of molecular lesions in cancer-related genes. Detection of active NF-kappa B signaling in 14 (58%) of 24 SMZLs prompted the...
- Digestive vacuoles of Plasmodium falciparum are selectively phagocytosed by and impair killing function of polymorphonuclear leukocytes
[作者：Dasari, P; Reiss, K; Lingelbach, K; Baumeister, S; Lucius, R; Udomsangpetch, R; Bhakdi, SC; Bhakdi, S,期刊：Blood, 页码：4946-4956 , 文章类型： Article，,卷期：2011年118-18]
- Sequestration of parasitized erythrocytes and dysregulation of the coagulation and complement system are hallmarks of severe Plasmodium falciparum malaria. A link between these events emerged through the discovery that t...
- The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome
[作者：McDermott, DH; Liu, Q; Ulrick, J; Kwatemaa, N; Anaya-O'Brien, S; Penzak, SR; Oliveira, J; Priel, DAL; Kelly, C; Garofalo, M; Littel, P; Marquesen, MM; Hilligoss, D; DeCastro, R; Fleisher, TA; Kuhns, DB; Malech, HL; Murphy, PM,期刊：Blood, 页码：4957-4962 , 文章类型： Article，,卷期：2011年118-18]
- WHIM syndrome is a rare congenital immunodeficiency disorder characterized by warts, hypogammaglobulinemia, infections, and myelokathexis (neutropenia because of impaired egress from the BM); most patients also have seve...
- The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome
[作者：Dale, DC; Bolyard, AA; Kelley, ML; Westrup, EC; Makaryan, V; Aprikyan, A; Wood, B; Hsu, FJ,期刊：Blood, 页码：4963-4966 , 文章类型： Article，,卷期：2011年118-18]
- Mutations in CXCR4 cause severe leukopenia in myelokathexis or WHIM syndrome. Plerixafor inhibits binding of CXCR4 to its ligand CXCL12. We investigated the effects of plerixafor (0.04 to 0.24 mg/kg) administered at 2-4 ...
- Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake
[作者：Serbanovic-Canic, J; Cvejic, A; Soranzo, N; Stemple, DL; Ouwehand, WH; Freson, K,期刊：Blood, 页码：4967-4976 , 文章类型： Article，,卷期：2011年118-18]
- Genomewide association meta-analysis studies have identified > 100 independent genetic loci associated with blood cell indices, including volume and count of platelets and erythrocytes. Although several of these loci enc...
- Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats
[作者：Theurl, I; Schroll, A; Sonnweber, T; Nairz, M; Theurl, M; Willenbacher, W; Eller, K; Wolf, D; Seifert, M; Sun, CC; Babitt, JL; Hong, CC; Menhall, T; Gearing, P; Lin, HY; Weiss, G,期刊：Blood, 页码：4977-4984 , 文章类型： Article，,卷期：2011年118-18]
- Anemia of chronic inflammation (ACI) is the most frequent anemia in hospitalized patients and is associated with significant morbidity. Amajor underlying mechanism of ACI is the retention of iron within cells of the reti...
- Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia
[作者：Ware, RE; Despotovic, JM; Mortier, NA; Flanagan, JM; He, J; Smeltzer, MP; Kimble, AC; Aygun, B; Wu, S; Howard, T; Sparreboom, A,期刊：Blood, 页码：4985-4991 , 文章类型： Article，,卷期：2011年118-18]
- Hydroxyurea therapy has proven laboratory and clinical efficacies for children with sickle cell anemia (SCA). When administered at maximum tolerated dose (MTD), hydroxyurea increases fetal hemoglobin (HbF) to levels rang...
- Heparin and warfarin anticoagulation intensity as predictors of recurrence after deep vein thrombosis or pulmonary embolism: a population-based cohort study
[作者：Heit, JA; Lahr, BD; Petterson, TM; Bailey, KR; Ashrani, AA; Melton, LJ,期刊：Blood, 页码：4992-4999 , 文章类型： Article，,卷期：2011年118-18]
- To test recommended anticoagulation measures as predictors of 180-day venous thromboembolism (VTE) recurrence, we identified all Olmsted County, MN residents with incident VTE over the 14-year period of 1984-1997, and fo...
- Critical role for Syk in responses to vascular injury
[作者：Andre, P; Morooka, T; Sim, D; Abe, K; Lowell, C; Nanda, N; Delaney, S; Siu, G; Yan, YB; Hollenbach, S; Pandey, A; Gao, HY; Wang, YM; Nakajima, K; Parikh, SA; Shi, C; Phillips, D; Owen, W; Sinha, U; Simon, DI,期刊：Blood, 页码：5000-5010 , 文章类型： Article，,卷期：2011年118-18]
- Although current antiplatelet therapies provide potent antithrombotic effects, their efficacy is limited by a heightened risk of bleeding and failure to affect vascular remodeling after injury. New lines of research sugg...
- Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and ROR gamma t in mice
[作者：Yu, Y; Wang, DP; Liu, C; Kaosaard, K; Semple, K; Anasetti, C; Yu, XZ,期刊：Blood, 页码：5011-5020 , 文章类型： Article，,卷期：2011年118-18]
- Allogeneic hematopoietic cell transplantation (HCT) is effective therapy for hematologic malignancies through T cell-mediated GVL effects. However, HCT benefits are frequently offset by the destructive GVHD, which is als...
- Low telomerase activity in CD4(+) regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation
[作者：Kawano, Y; Kim, HT; Matsuoka, K; Bascug, G; McDonough, S; Ho, VT; Cutler, C; Koreth, J; Alyea, EP; Antin, JH; Soiffer, RJ; Ritz, J,期刊：Blood, 页码：5021-5030 , 文章类型： Article，,卷期：2011年118-18]
- CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) play an important role in the control of chronic graft-versus-host disease (cGVHD). In this study, we examined telomere length and telomerase activity of Treg and conventio...
- Inhibition of IL-32 activation by alpha-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model
[作者：Marcondes, AM; Li, X; Tabellini, L; Bartenstein, M; Kabacka, J; Sale, GE; Hansen, JA; Dinarello, CA; Deeg, HJ,期刊：Blood, 页码：5031-5039 , 文章类型： Article，,卷期：2011年118-18]
- Interleukin (IL)-32 was originally identified in natural killer cells and IL-2-activated human T lymphocytes. As T cells are activated in allogeneic transplantation, we determined the role of IL-32 in human mixed lymphoc...
- BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium
[作者：Helbing, T; Rothweiler, R; Ketterer, E; Goetz, L; Heinke, J; Grundmann, S; Duerschmied, D; Patterson, C; Bode, C; Moser, M,期刊：Blood, 页码：5040-5049 , 文章类型： Article，,卷期：2011年118-18]
- The endothelium plays a pivotal role in vascular inflammation. Here we study bone morphogenetic protein (BMP) signaling in endothelial inflammation and in particular the role of BMPER, an extracellular BMP modulator that...
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