- Complexity Generation in Fungal Peptidyl Alkaloid Biosynthesis: Oxidation of Fumiquinazoline A to the Heptacyclic Hemiaminal Fumiquinazoline C by the Flavoenzyme Af12070 from Aspergillus fumigatus
[作者:Ames, BD; Haynes, SW; Gao, X; Evans, BS; Kelleher, NL; Tang, Y; Walsh, CT,期刊:Biochemistry, 页码:8756-8769 , 文章类型: Article,,卷期:2011年50-40]
- The human pathogen Aspergillus fumigatus makes a series of fumiquinazoline (FQ) peptidyl alkaloids of increasing scaffold complexity using L-Trp, 2 equiv of L-Ala, and the non-proteinogenic amino acid anthranilate as bui...
- Effects of a Protecting Osmolyte on the Ion Atmosphere Surrounding DNA Duplexes
[作者:Blose, JM; Pabit, SA; Meisburger, SP; Li, L; Jones, CD; Pollack, L,期刊:Biochemistry, 页码:8540-8547 , 文章类型: Article,,卷期:2011年50-40]
- Osmolytes are small, chemically diverse, organic solutes that function as an essential component of cellular stress response. Protecting osmolytes enhance protein stability via preferential exclusion, and nonprotecting o...
- Substitutions of Coenzyme-Binding, Nonpolar Residues Improve the Low-Temperature Activity of Thermophilic Dehydrogenases
[作者:Hayashi, S; Akanuma, S; Onuki, W; Tokunaga, C; Yamagishi, A,期刊:Biochemistry, 页码:8583-8593 , 文章类型: Article,,卷期:2011年50-40]
- Although enzymes of thermophilic organisms are often very resistant to thermal denaturation, they are usually less active than their mesophilic or psychrophilic homologues at moderate or low temperatures. To explore the ...
- Structure and Mechanism of PhnP, a Phosphodiesterase of the Carbon-Phosphorus Lyase Pathway
[作者:He, SM; Wathier, M; Podzelinska, K; Wong, M; McSorley, FR; Asfaw, A; Hove-Jensen, B; Jia, ZC; Zechel, DL,期刊:Biochemistry, 页码:8603-8615 , 文章类型: Article,,卷期:2011年50-40]
- PhnP is a phosphodiesterase that plays an important role within the bacterial carbon-phosphorus lyase (CP-lyase) pathway by recycling a "dead-end" intermediate, 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate, that is for...
- Structural and Mechanistic Analysis of a Novel Class of Shikimate Dehydrogenases: Evidence for a Conserved Catalytic Mechanism in the Shikimate Dehydrogenase Family
[作者:Peek, J; Lee, J; Hu, S; Senisterra, G; Christendat, D,期刊:Biochemistry, 页码:8616-8627 , 文章类型: Article,,卷期:2011年50-40]
- Shikimate dehydrogenase (SDH) catalyzes the reversible NADPH-dependent reduction of 3-dehydroshikimate to shikimate. This reaction represents the fourth step of the shikimate pathway, the essential route for the biosynth...
- Simultaneous Stereoinversion and Isomerization at the Asp-4 Residue in beta B2-Crystallin from the Aged Human Eye Lenses
[作者:Fujii, N; Kawaguchi, T; Sasaki, H; Fujii, N,期刊:Biochemistry, 页码:8628-8635 , 文章类型: Article,,卷期:2011年50-40]
- The lens proteins are composed of alpha-, beta-, and gamma-crystallins that interact with each other to maintain the transparency and refractive power of the lens. Because the lens crystallins are long-lived proteins, th...
- Design, Overexpression, and Purification of Polymerization-Blocked Yeast alpha beta-Tubulin Mutants
[作者:Johnson, V; Ayaz, P; Huddleston, P; Rice, LM,期刊:Biochemistry, 页码:8636-8644 , 文章类型: Article,,卷期:2011年50-40]
- Microtubule dynamics play essential roles in intracellular organization and cell division. They result from structural and biochemical properties of alpha beta-tubulin heterodimers and how these polymerizing subunits int...
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