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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Alleviation of post-radical prostatectomy cavernosal fibrosis: future directions and potential utility for PDE5 inhibitors [作者：El-Sakka, AI,期刊：Expert opinion on investigational drugs, 页码：1305-1309 , 文章类型： Editorial Material，,卷期：2011年20-10] Reversion of cavernosal fibrosis remains a controversial issue. The relative smooth muscle cells' loss that happens with cavernosal nerve damage and their impact on deterioration of erectile function were demonstrated in... Discontinued drugs in 2010: cardiovascular drugs [作者：Zhao, HP; Zhang, XS; Xiang, BR,期刊：Expert opinion on investigational drugs, 页码：1311-1325 , 文章类型： Article，,卷期：2011年20-10] This perspective is a paper discussing drugs dropped from clinical development in the previous years. Specifically, this paper focuses on 16 cardiovascular drugs discontinued in 2010 after reaching Phase I - III clinical... The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs [作者：Richard, BM; Ott, LR; Haan, D; Brubaker, AN; Cole, PI; Nelson, KG; Ross, PE; Rebelatto, MC; Newton, PE,期刊：Expert opinion on investigational drugs, 页码：1327-1341 , 文章类型： Article，,卷期：2011年20-10] Objective: DepoFoam(R) bupivacaine (DB) is in development for prolonged postoperative analgesia. Studies were conducted to evaluate the potential local and systemic toxicity and any effect on wound healing after wound in... Thymidylate synthase inhibitors for non-small cell lung cancer [作者：Galvani, E; Peters, GJ; Giovannetti, E,期刊：Expert opinion on investigational drugs, 页码：1343-1356 , 文章类型： Review，,卷期：2011年20-10] Introduction: The folate-dependent enzyme thymidylate synthase (TS) plays a pivotal role in DNA replication/repair and cancer cell proliferation, and represents a valid target for the treatment of several tumor types, in... Emerging therapeutics for advanced thyroid malignancies: rationale and targeted approaches [作者：Harris, PJ; Bible, KC,期刊：Expert opinion on investigational drugs, 页码：1357-1375 , 文章类型： Review，,卷期：2011年20-10] Introduction: Thyroid cancer is an emerging public health concern. In the USA, its incidence has doubled in the past decade, making it the eighth most commonly diagnosed neoplasmin 2010. Despite this alarming increase, m... The clinical development of FLT3 inhibitors in acute myeloid leukemia [作者：Knapper, S,期刊：Expert opinion on investigational drugs, 页码：1377-1395 , 文章类型： Review，,卷期：2011年20-10] Introduction: Activating mutations of the FMS-like tyrosine kinase 3 (FLT3) gene occur at high frequency in acute myeloid leukemia (AML), being detected in > 30% of patients at diagnosis and carrying a profound negative ... Targeting Mcl-1 for the therapy of cancer [作者：Quinn, BA; Dash, R; Azab, B; Sarkar, S; Das, SK; Kumar, S; Oyesanya, RA; Dasgupta, S; Dent, P; Grant, S; Rahmani, M; Curiel, DT; Dmitriev, I; Hedvat, M; Wei, J; Wu, BN; Stebbins, JL; Reed, JC; Pellecchia, M; Sarkar, D; Fisher, PB,期刊：Expert opinion on investigational drugs, 页码：1397-1411 , 文章类型： Review，,卷期：2011年20-10] Introduction: Human cancers are genetically and epigenetically heterogeneous and have the capacity to commandeer a variety of cellular processes to aid in their survival, growth and resistance to therapy. One strategy is... Blocking the interaction of vascular endothelial growth factor receptors with their ligands and their effector signaling as a novel therapeutic target for cancer: time for a new look? [作者：Bruce, D; Tan, PH,期刊：Expert opinion on investigational drugs, 页码：1413-1434 , 文章类型： Review，,卷期：2011年20-10] Introduction: The interaction between the VEGFRs and their ligands plays an important role in tumor angiogenesis. Despite a series of problems encountered during early work on blocking growth factors, current evidence in... Taribavirin in the treatment of hepatitis C [作者：Deming, P; Arora, S,期刊：Expert opinion on investigational drugs, 页码：1435-1443 , 文章类型： Editorial Material，,卷期：2011年20-10] Introduction: Treatment of chronic hepatitis C virus (HCV) is limited by substantial side effects including ribavirin-induced hemolytic anemia. Taribavirin, a ribavirin prodrug, was designed to concentrate within the liv... Vorapaxar: a novel protease-activated receptor-1 inhibitor [作者：Gurbel, PA; Jeong, YH; Tantry, US,期刊：Expert opinion on investigational drugs, 页码：1445-1453 , 文章类型： Editorial Material，,卷期：2011年20-10] Introduction: Platelet activation and reactivity are pivotal for both acute and chronic atherothrombotic event occurrences.Areas covered: Only 20% relative risk (similar to 2% absolute risk) reduction associated with new... Entinostat for treatment of solid tumors and hematologic malignancies [作者：Knipstein, J; Gore, L,期刊：Expert opinion on investigational drugs, 页码：1455-1467 , 文章类型： Editorial Material，,卷期：2011年20-10] :Introduction: A key feature of malignant cells is inappropriate gene suppression resulting in uncontrolled proliferation, continued cell cycling and a lack of differentiation. Histone deacetylase inhibitors (HDACi) are ... S-1: a promising new oral fluoropyrimidine derivative (vol 18, pg 335, 2009) [作者：Schoffski, P,期刊：Expert opinion on investigational drugs, 页码：1469-1469 , 文章类型： Correction，,卷期：2011年20-10]