个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   Excited-State Control of Protein Activity [作者：Vendruscolo, M,期刊：Journal of Molecular Biology, 页码：153-154 , 文章类型： Editorial Material，,卷期：2011年412-2] cAMP-Dependent Protein Kinase A Selects the Excited State of the Membrane Substrate Phospholamban [作者：Masterson, LR; Yu, T; Shi, L; Wang, Y; Gustavsson, M; Mueller, MM; Veglia, G,期刊：Journal of Molecular Biology, 页码：155-164 , 文章类型： Article，,卷期：2011年412-2] Phosphorylation of membrane proteins is a central regulatory and signaling mechanism across cell compartments. However, the recognition process and phosphorylation mechanism of membrane-bound substrates by kinases are vi... YidC-Driven Membrane Insertion of Single Fluorescent Pf3 Coat Proteins [作者：Ernst, S; Schonbauer, AK; Bar, G; Borsch, M; Kuhn, A,期刊：Journal of Molecular Biology, 页码：165-175 , 文章类型： Article，,卷期：2011年412-2] The membrane insertion of single bacteriophage Pf3 coat proteins was observed by confocal fluorescence microscopy. Within seconds after addition of the purified and fluorescently labeled protein to liposomes or proteolip... Crystal Structure of Crotoxin Reveals Key Residues Involved in the Stability and Toxicity of This Potent Heterodimeric beta-Neurotoxin [作者：Faure, G; Xu, HJ; Saul, FA,期刊：Journal of Molecular Biology, 页码：176-191 , 文章类型： Article，,卷期：2011年412-2] The crystal structure of crotoxin, a potent presynaptic neurotoxin from Crotalus durissus terrificus, was solved at 1.35 angstrom resolution. It shows the architecture of the three disulfide-linked polypeptide chains (al... The Dimeric Structure of the Cpn60.2 Chaperonin of Mycobacterium tuberculosis at 2.8 angstrom Reveals Possible Modes of Function [作者：Shahar, A; Melamed-Frank, M; Kashi, Y; Shimon, L; Adir, N,期刊：Journal of Molecular Biology, 页码：192-203 , 文章类型： Article，,卷期：2011年412-2] Mycobacterium tuberculosis expresses two proteins (Cpn60.1 and Cpn60.2) that belong to the chaperonin (Cpn) family of heat shock proteins. Studies have shown that the two proteins have different functional roles in the b... Structure-Guided Activity Restoration of the Silkworm Glutathione Transferase Omega GSTO3-3 [作者：Chen, BY; Ma, XX; Guo, PC; Tan, X; Li, WF; Yang, JP; Zhang, NN; Chen, YX; Xia, QY; Zhou, CZ,期刊：Journal of Molecular Biology, 页码：204-211 , 文章类型： Article，,卷期：2011年412-2] Glutathione transferases (GSTs) are ubiquitous detoxification enzymes that conjugate hydrophobic xenobiotics with reduced glutathione. The silkworm Bombyx mori encodes four isoforms of GST Omega (GSTO), featured with a c... Phylogeny-Based Design of a B-Subunit of DNA Gyrase and Its ATPase Domain Using a Small Set of Homologous Amino Acid Sequences [作者：Akanuma, S; Iwami, S; Yokoi, T; Nakamura, N; Watanabe, H; Yokobori, S; Yamagishi, A,期刊：Journal of Molecular Biology, 页码：212-225 , 文章类型： Article，,卷期：2011年412-2] We have developed a phylogeny-based design method that has been used to produce mutated proteins with enhanced thermal stabilities. We previously validated the predictive worth of the method by producing and characterizi... Structural Basis of Importin-alpha-Mediated Nuclear Transport for Ku70 and Ku80 [作者：Takeda, AAS; de Barros, AC; Chang, CW; Kobe, B; Fontes, MRM,期刊：Journal of Molecular Biology, 页码：226-234 , 文章类型： Article，,卷期：2011年412-2] Ku70 and Ku80 form a heterodimeric complex involved in multiple nuclear processes. This complex plays a key role in DNA repair due to its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologou... The Binding Mechanism of a Peptidic Cyclic Serine Protease Inhibitor [作者：Jiang, LG; Svane, ASP; Sorensen, HP; Jensen, JK; Hosseini, M; Chen, Z; Weydert, C; Nielsen, JT; Christensen, A; Yuan, C; Jensen, KJ; Nielsen, NC; Malmendal, A; Huang, MD; Andreasen, PA,期刊：Journal of Molecular Biology, 页码：235-250 , 文章类型： Article，,卷期：2011年412-2] Serine proteases are classical objects for studies of catalytic and inhibitory mechanisms as well as interesting as therapeutic targets. Since small-molecule serine protease inhibitors generally suffer from specificity p... The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder [作者：Schneider, EV; Bottcher, J; Blaesse, M; Neumann, L; Huber, R; Maskos, K,期刊：Journal of Molecular Biology, 页码：251-266 , 文章类型： Article，,卷期：2011年412-2] Cyclin-dependent kinase (CDK) 8 associates with cyclin C (CycC) and belongs to the CDK module of the Mediator of transcription, together with MED12 and MED13. CDK8 is involved in the regulation of mRNA transcription and ... Kinetic Recognition of the Retinoblastoma Tumor Suppressor by a Specific Protein Target [作者：Chemes, LB; Sanchez, IE; de Prat-Gay, G,期刊：Journal of Molecular Biology, 页码：267-284 , 文章类型： Article，,卷期：2011年412-2] The retinoblastoma tumor suppressor (Rb) plays a key role in cell cycle control and is linked to various types of human cancer. Rb binds to the LxCxE motif, present in a number of cellular and viral proteins such as AdE1... Conformation Effects of Base Modification on the Anticodon Stem-Loop of Bacillus subtilis tRNA(Tyr) [作者：Denmon, AP; Wang, JC; Nikonowicz, EP,期刊：Journal of Molecular Biology, 页码：285-303 , 文章类型： Article，,卷期：2011年412-2] tRNA molecules contain 93 chemically unique nucleotide base modifications that expand the chemical and biophysical diversity of RNA and contribute to the overall fitness of the cell. Nucleotide modifications of tRNA conf... NMR Analysis of a Kinetically Trapped Intermediate of a Disulfide-Deficient Mutant of the Starch-Binding Domain of Glucoamylase [作者：Sugimoto, H; Noda, Y; Segawa, S,期刊：Journal of Molecular Biology, 页码：304-315 , 文章类型： Article，,卷期：2011年412-2] A thermally unfolded disulfide-deficient mutant of the starch-binding domain of glucoamylase refolds into a kinetically trapped metastable intermediate when subjected to a rapid lowering of temperature. We attempted to c... Lesion Bypass Activity of DNA Polymerase theta (POLO) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts (vol 405, pg 642, 2011) [作者：Hogg, M; Seki, M; Wood, RD; Doublie, S; Wallace, SS,期刊：Journal of Molecular Biology, 页码：316-316 , 文章类型： Correction，,卷期：2011年412-2]