- The Structure of E. coil IgG-Binding Protein D Suggests a General Model for Bending and Binding in Trimeric Autotransporter Adhesins
[作者:Leo, JC; Lyskowski, A; Hattula, K; Hartmann, MD; Schwarz, H; Butcher, SJ; Linke, D; Lupas, AN; Goldman, A,期刊:Structure, 页码:1021-1030 , 文章类型: Article,,卷期:2011年19-7]
- The Escherichia coil Ig-binding (Eib) proteins are trimeric autotransporter adhesins (TAAs) and receptors for IgG Fc. We present the structure of a large fragment of the passenger domain of EibD, the first TAA structure ...
- Dynamic Allostery: Linkers Are Not Merely Flexible
[作者:Ma, BY; Tsai, CJ; Haliloglu, T; Nussinov, R,期刊:Structure, 页码:907-917 , 文章类型: Review,,卷期:2011年19-7]
- Most proteins consist of multiple domains. How do linkers efficiently transfer information between sites that are on different domains to activate the protein? Mere flexibility only implies that the conformations would b...
- Structural Basis for the Regulation of Cysteine-Protease Activity by a New Class of Protease Inhibitors in Plasmodium
[作者:Hansen, G; Heitmann, A; Witt, T; Li, HL; Jiang, HL; Shen, X; Heussler, VT; Rennenberg, A; Hilgenfeld, R,期刊:Structure, 页码:919-929 , 文章类型: Article,,卷期:2011年19-7]
- Plasmodium cysteine proteases are essential for host-cell invasion and egress, hemoglobin degradation, and intracellular development of the parasite. The temporal, site-specific regulation of cysteine-protease activity i...
- Protein-RNA and Protein-Protein Recognition by Dual KH1/2 Domains of the Neuronal Splicing Factor Nova-1
[作者:Teplova, M; Malinina, L; Darnell, JC; Song, JK; Lu, M; Abagyan, R; Musunuru, K; Teplov, A; Burley, SK; Darnell, RB; Patel, DJ,期刊:Structure, 页码:930-944 , 文章类型: Article,,卷期:2011年19-7]
- Nova onconeural antigens are neuron-specific RNA-binding proteins implicated in paraneoplastic opsoclonus-myoclonus-ataxia (POMA) syndrome. Nova harbors three K-homology (KH) motifs implicated in alternate splicing regul...
- NusA Interaction with the alpha Subunit of E-coil RNA Polymerase Is via the UP Element Site and Releases Autoinhibition
[作者:Schweimer, K; Prasch, S; Sujatha, PS; Bubunenko, M; Gottesman, ME; Rosch, P,期刊:Structure, 页码:945-954 , 文章类型: Article,,卷期:2011年19-7]
- Elongating Escherichia coil RNAP is modulated by NusA protein. The C-terminal domain (CTD) of the RNAP alpha subunit (alpha CTD) interacts with the acidic CTD 2 (AR2) of NusA, releasing the autoinhibitory blockade of the...
- Interconversion of Two GDP-Bound Conformations and Their Selection in an Art-Family Small G Protein
[作者:Okamura, H; Nishikiori, M; Xiang, HY; Ishikawa, M; Katoh, E,期刊:Structure, 页码:988-998 , 文章类型: Article,,卷期:2011年19-7]
- ADP-ribosylation factor (Arf) and other Art-family small G proteins participate in many cellular functions via their characteristic GTP/GDP conformational cycles, during which a nucleotide*Mg(2+)-binding site communicate...
- Structure of a Yeast RNase III dsRBD Complex with a Noncanonical RNA Substrate Provides New Insights into Binding Specificity of dsRBDs
[作者:Wang, ZH; Hartman, E; Roy, K; Chanfreau, G; Feigon, J,期刊:Structure, 页码:999-1010 , 文章类型: Article,,卷期:2011年19-7]
- dsRBDs often bind dsRNAs with some specificity, yet the basis for this is poorly understood. Rnt1p, the major RNase Ill in Saccharomyces cerevisiae, cleaves RNA substrates containing hairpins capped by A/uGNN tetraloops,...
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