- KL1 Internal Repeat Mediates Klotho Tumor Suppressor Activities and Inhibits bFGF and IGF-I Signaling in Pancreatic Cancer
[作者：Abramovitz, L; Rubinek, T; Ligumsky, H; Bose, S; Barshack, I; Avivi, C; Kaufman, B; Wolf, I,期刊：Clinical Cancer Research, 页码：4254-4266 , 文章类型： Article，,卷期：2011年17-13]
- Purpose: Klotho is a transmembrane protein which can be shed, act as a circulating hormone and modulate the insulin-like growth factor (IGF)-I and the fibroblast growth factor (FGF) pathways. We have recently identified ...
- BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer
[作者：Bhan, S; Negi, SS; Shao, CB; Glazer, CA; Chuang, A; Gaykalova, DA; Sun, WY; Sidransky, D; Ha, PK; Califano, JA,期刊：Clinical Cancer Research, 页码：4267-4276 , 文章类型： Article，,卷期：2011年17-13]
- Purpose: Aim of this study was to determine whether BORIS (Brother of the Regulator of Imprinted Sites) is a regulator of MAGEA2, MAGEA3, and MAGEA4 genes in lung cancer. Experimental Design: Changes in expression of MAG...
- Getting Personal with Melanoma
[作者：Heslop, H,期刊：Clinical Cancer Research, 页码：4189-4191 , 文章类型： Editorial Material，,卷期：2011年17-13]
- Long-term follow-up of patients with metastatic melanoma who received adoptive immunotherapy with autologous tumor infiltrating lymphocytes shows that patients who attained complete remission had durable responses, with ...
- Analysis of Promoter CpG Island Hypermethylation in Cancer: Location, Location, Location!
[作者：van Vlodrop, IJH; Niessen, HEC; Derks, S; Baldewijns, MMLL; van Criekinge, W; Herman, JG; van Engeland, M,期刊：Clinical Cancer Research, 页码：4225-4231 , 文章类型： Article，,卷期：2011年17-13]
- The genetic and epigenetic alterations that underlie cancer pathogenesis are rapidly being identified. This provides novel insights in tumor biology as well as in potential cancer biomarkers. The somatic mutations in can...
- Clinical Significance of miR-146a in Gastric Cancer Cases
[作者：Kogo, R; Mimori, K; Tanaka, F; Komune, S; Mori, M,期刊：Clinical Cancer Research, 页码：4277-4284 , 文章类型： Article，,卷期：2011年17-13]
- Purpose: The profiles of microRNAs change significantly in gastric cancer. MiR-146a is reported to be a tumor suppressor in pancreatic cancer, breast cancer, and prostate cancer. We investigated the clinical significance...
- PLK1 Is Transcriptionally Activated by NF-kappa B during Cell Detachment and Enhances Anoikis Resistance through Inhibiting beta-Catenin Degradation in Esophageal Squamous Cell Carcinoma
[作者：Lin, DC; Zhang, Y; Pan, QJ; Yang, H; Shi, ZZ; Xie, ZH; Wang, BS; Hao, JJ; Zhang, TT; Xu, X; Zhan, QM; Wang, MR,期刊：Clinical Cancer Research, 页码：4285-4295 , 文章类型： Article，,卷期：2011年17-13]
- Purpose: To investigate the molecular mechanisms through which polo-like kinase-1 (PLK1) takes part in anoikis resistance of esophageal squamous cell carcinoma (ESCC) cells. Experimental Design: The role of PLK1 in cell ...
- Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF-beta
[作者：Lohr, J; Ratliff, T; Huppertz, A; Ge, YZ; Dictus, C; Ahmadi, R; Grau, S; Hiraoka, N; Eckstein, V; Ecker, RC; Korff, T; von Deimling, A; Unterberg, A; Beckhove, P; Herold-Mende, C,期刊：Clinical Cancer Research, 页码：4296-4308 , 文章类型： Article，,卷期：2011年17-13]
- Purpose: In glioma-in contrast to various other cancers-the impact of T-lymphocytes on clinical outcome is not clear. We investigated the clinical relevance and regulation of T-cell infiltration in glioma. Experimental D...
- WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe
[作者：Hamer, PCD; Mir, SE; Noske, D; Van Noorden, CJF; Wurdinger, T,期刊：Clinical Cancer Research, 页码：4200-4207 , 文章类型： Article，,卷期：2011年17-13]
- WEE1 kinase is a key molecule in maintaining G(2)-cell-cycle checkpoint arrest for premitotic DNA repair. Whereas normal cells repair damaged DNA during G(1)-arrest, cancer cells often have a deficient G(1)-arrest and la...
- Immune Recruitment and Therapeutic Synergy: Keys to Optimizing Oncolytic Viral Therapy?
[作者：Naik, JD; Twelves, CJ; Selby, PJ; Vile, RG; Chester, JD,期刊：Clinical Cancer Research, 页码：4214-4224 , 文章类型： Review，,卷期：2011年17-13]
- Oncolytic viruses consist of a diverse range of DNA and RNA viruses traditionally thought to mediate their effects by exploiting aberrations in tumor pathways, allowing preferential viral replication in, and killing of, ...
- Programmed Death Ligand 1 Is Expressed by Non-Hodgkin Lymphomas and Inhibits the Activity of Tumor-Associated T Cells
[作者：Andorsky, DJ; Yamada, RE; Said, J; Pinkus, GS; Betting, DJ; Timmerman, JM,期刊：Clinical Cancer Research, 页码：4232-4244 , 文章类型： Article，,卷期：2011年17-13]
- Purpose: Programmed death ligand 1 (PD-L1) is expressed on antigen-presenting cells and inhibits activation of T cells through its receptor PD-1. PD-L1 is aberrantly expressed on some epithelial malignancies and Hodgkin ...
- Primary Central Nervous System Lymphomas: A Validation Study of Array-Based Comparative Genomic Hybridization in Formalin-Fixed Paraffin-Embedded Tumor Specimens
[作者：Braggio, E; McPhail, ER; Macon, W; Lopes, MB; Schiff, D; Law, M; Fink, S; Sprau, D; Giannini, C; Dogan, A; Fonseca, R; O'Neill, BP,期刊：Clinical Cancer Research, 页码：4245-4253 , 文章类型： Article，,卷期：2011年17-13]
- Purpose: Only a limited number of genetic studies have been conducted in primary central nervous system lymphomas (PCNSL), partly due to the rarity of the tumors and the very limited amount of available tissue. In this r...
- MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin
[作者：Nardiello, T; Jungbluth, AA; Mei, A; DiLiberto, M; Huang, XG; Dabrowski, A; Andrade, VCC; Wasserstrum, R; Ely, S; Niesvizky, R; Pearse, R; Coleman, M; Jayabalan, DS; Bhardwaj, N; Old, LJ; Chen-Kiang, S; Cho, HJ,期刊：Clinical Cancer Research, 页码：4309-4319 , 文章类型： Article，,卷期：2011年17-13]
- Purpose: The type I Melanoma Antigen GEnes (MAGEs) are commonly expressed in cancers, fueling speculation that they may be therapeutic targets with oncogenic potential. They form complexes with RING domain proteins that ...
- Integrated, Genome-Wide Screening for Hypomethylated Oncogenes in Salivary Gland Adenoid Cystic Carcinoma
[作者：Shao, CB; Sun, WY; Tan, M; Glazer, CA; Bhan, S; Zhong, XL; Fakhry, C; Sharma, R; Westra, WH; Hoque, MO; Moskaluk, CA; Sidransky, D; Califano, JA; Ha, PK,期刊：Clinical Cancer Research, 页码：4320-4330 , 文章类型： Article，,卷期：2011年17-13]
- Purpose: Salivary gland adenoid cystic carcinoma (ACC) is a rare malignancy that is poorly understood. To look for relevant oncogene candidates under the control of promoter methylation, an integrated, genome-wide screen...
- The Akt Inhibitor ISC-4 Activates Prostate Apoptosis Response Protein-4 and Reduces Colon Tumor Growth in a Nude Mouse Model
[作者：Sharma, AK; Kline, CL; Berg, A; Amin, S; Irby, RB,期刊：Clinical Cancer Research, 页码：4474-4483 , 文章类型： Article，,卷期：2011年17-13]
- Purpose: Prostate apoptosis response protein-4 (Par-4) sensitizes cells to chemotherapy; however, Akt1 inactivates Par-4. Previously we showed that Par-4-overexpressing colon cancer cells responded more readily to 5-fluo...
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