- Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma
[作者:Kubo, T; Toyooka, S; Tsukuda, K; Sakaguchi, M; Fukazawa, T; Soh, J; Asano, H; Ueno, T; Muraoka, T; Yamamoto, H; Nasu, Y; Kishimoto, T; Pass, HI; Matsui, H; Huh, N; Miyoshi, S,期刊:Clinical Cancer Research, 页码:4965-4974 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: Malignant pleural mesothelioma (MPM) is an aggressive tumor with a dismal prognosis. Unlike other malignancies, TP53 mutations are rare in MPM. Recent studies have showed that altered expression of microRNA (miR...
- Interleukin-7 Inhibits Tumor-Induced CD27(-)CD28(-) Suppressor T Cells: Implications for Cancer Immunotherapy
[作者:Zhang, Y; Pfannenstiel, LW; Bolesta, E; Montes, CL; Zhang, XY; Chapoval, AI; Gartenhaus, RB; Strome, SE; Gastman, BR,期刊:Clinical Cancer Research, 页码:4975-4986 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: We have previously reported that many types of tumors can induce changes in human T cells that lead to the acquisition of suppressive function and phenotypic alterations resembling those found in senescent T cel...
- The Efficacy of IGF-I Receptor Monoclonal Antibody against Human Gastrointestinal Carcinomas is Independent of k-ras Mutation Status
[作者:Ii, M; Li, H; Adachi, Y; Yamamoto, H; Ohashi, H; Taniguchi, H; Arimura, Y; Carbone, DP; Imai, K; Shinomura, Y,期刊:Clinical Cancer Research, 页码:5048-5059 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: Insulin-like growth factor (IGF)-I receptor (IGF-IR) signaling is required for carcinogenicity and proliferation of gastrointestinal cancers. We have previously shown successful targeting therapy for colorectal,...
- Pertuzumab in Combination with Trastuzumab Shows Significantly Enhanced Antitumor Activity in HER2-Positive Human Gastric Cancer Xenograft Models
[作者:Yamashita-Kashima, Y; Iijima, S; Yorozu, K; Furugaki, K; Kurasawa, M; Ohta, M; Fujimoto-Ouchi, K,期刊:Clinical Cancer Research, 页码:5060-5070 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: We investigated the antitumor activity of the combination of two different humanized monoclonal human epidermal growth factor receptor (HER) 2 antibodies, pertuzumab and trastuzumab, for gastric cancer. Experime...
- HER2-Affitoxin: A Potent Therapeutic Agent for the Treatment of HER2-Overexpressing Tumors
[作者:Zielinski, R; Lyakhov, I; Hassan, M; Kuban, M; Shafer-Weaver, K; Gandjbakhche, A; Capala, J,期刊:Clinical Cancer Research, 页码:5071-5081 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: Cancers overexpressing the HER2/neu gene are usually more aggressive and are associated with poor prognosis. Although trastuzumab has significantly improved the outcome, many tumors do not respond or acquire res...
- Adoptive Transfer of Tumor Reactive B Cells Confers Host T-Cell Immunity and Tumor Regression
[作者:Li, Q; Lao, XM; Pan, Q; Ning, N; Yet, J; Xu, YX; Li, SP; Chang, AE,期刊:Clinical Cancer Research, 页码:4987-4995 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: We investigated the antitumor reactivity of adoptively transferred effector B cells and the mechanisms by which they may mediate tumor regression in a spontaneous metastases model. Experimental Design: 4T1 breas...
- Targeting GPCR-Mediated p70S6K Activity May Improve Head and Neck Cancer Response to Cetuximab
[作者:Bhola, NE; Thomas, SM; Freilino, M; Joyce, S; Sahu, A; Maxwell, J; Argiris, A; Seethala, R; Grandis, JR,期刊:Clinical Cancer Research, 页码:4996-5004 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: Epidermal growth factor receptor (EGFR) overexpression is correlated with decreased survival in head and neck cancer (HNC) where the addition of EGFR inhibition to standard chemoradiation approaches has improved...
- High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma
[作者:Schulte, JH; Bachmann, HS; Brockmeyer, B; DePreter, K; Oberthur, A; Ackermann, S; Kahlert, Y; Pajtler, K; Theissen, J; Westermann, F; Vandesompele, J; Speleman, F; Berthold, F; Eggert, A; Brors, B; Hero, B; Schramm, A; Fischer, M,期刊:Clinical Cancer Research, 页码:5082-5092 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: Genomic alterations of the anaplastic lymphoma kinase (ALK) gene have been postulated to contribute to neuroblastoma pathogenesis. This study aimed to determine the interrelation of ALK mutations, ALK expression...
- FDG-PET as a Potential Tool for Selecting Patients with Advanced Non-Small Cell Lung Cancer Who May Be Spared Maintenance Therapy after First-Line Chemotherapy
[作者:Yoon, DH; Baek, S; Choi, CM; Lee, DH; Suh, C; Ryu, JS; Moon, DH; Lee, JS; Kim, SW,期刊:Clinical Cancer Research, 页码:5093-5100 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: To investigate whether 18F-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) may be a potential tool to select a subgroup of patients who might be spared maintenance treatment, if the metabolic respo...
- The National Institute for Health and Clinical Excellence and Its Role in Assessing the Value of New Cancer Treatments in England and Wales
[作者:Trowman, R; Chung, H; Longson, C; Littlejohns, P; Clark, P,期刊:Clinical Cancer Research, 页码:4930-4935 , 文章类型: Article,,卷期:2011年17-15]
- The boundaries of medical science in the treatment of cancer are constantly extending. Developments of existing treatments, innovative approaches, new discoveries, and more targeted therapeutic options are translating in...
- Fibroblast Growth Factor Receptors Are Components of Autocrine Signaling Networks in Head and Neck Squamous Cell Carcinoma Cells
[作者:Marshall, ME; Hinz, TK; Kono, SA; Singleton, KR; Bichon, B; Ware, KE; Marek, L; Frederick, BA; Raben, D; Heasley, LE,期刊:Clinical Cancer Research, 页码:5016-5025 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: We previously reported that a fibroblast growth factor (FGF) receptor (FGFR) signaling pathway drives growth of lung cancer cell lines of squamous and large cell histologies. Herein, we explored FGFR dependency ...
- Treatment-Induced Oxidative Stress and Cellular Antioxidant Capacity Determine Response to Bortezomib in Mantle Cell Lymphoma
[作者:Weniger, MA; Rizzatti, EG; Perez-Galan, P; Liu, DL; Wang, QY; Munson, PJ; Raghavachari, N; White, T; Tweito, MM; Dunleavy, K; Ye, YH; Wilson, WH; Wiestner, A,期刊:Clinical Cancer Research, 页码:5101-5112 , 文章类型: Article,,卷期:2011年17-15]
- Purpose: Proteasome inhibition disrupts protein homeostasis and induces apoptosis. Up to 50% of patients with relapsed mantle cell lymphoma (MCL) respond to bortezomib. We used gene expression profiling to investigate th...
|