- Exploring Breast Cancer Estrogen Disposition: The Basis for Endocrine Manipulation
[作者：Lonning, PE; Haynes, BP; Straume, AH; Dunbier, A; Helle, H; Knappskog, S; Dowsett, M,期刊：Clinical Cancer Research, 页码：4948-4958 , 文章类型： Review，,卷期：2011年17-15]
- Although normal breast tissue and breast cancer estrogens are known to be elevated compared with plasma estrogen levels, the mechanism behind this phenomenon has been an issue of debate for 2 decades. If local estrogen a...
- To DNA or not to DNA? That Is the Question, When It Comes to Molecular Subtyping for the Clinic!
[作者：Smeets, SJ; Harjes, U; van Wieringen, WN; Sie, D; Brakenhoff, RH; Meijer, GA; Ylstra, B,期刊：Clinical Cancer Research, 页码：4959-4964 , 文章类型： Article，,卷期：2011年17-15]
- Genome-wide RNA expression profiling has yielded tumor subtypes with strong predictive or prognostic value for a wide variety of cancers. Recently, for breast cancer two RNA expression classifiers have been adopted by th...
- The National Institute for Health and Clinical Excellence and Its Role in Assessing the Value of New Cancer Treatments in England and Wales
[作者：Trowman, R; Chung, H; Longson, C; Littlejohns, P; Clark, P,期刊：Clinical Cancer Research, 页码：4930-4935 , 文章类型： Article，,卷期：2011年17-15]
- The boundaries of medical science in the treatment of cancer are constantly extending. Developments of existing treatments, innovative approaches, new discoveries, and more targeted therapeutic options are translating in...
- Stem Cell Quiescence
[作者：Li, L; Bhatia, R,期刊：Clinical Cancer Research, 页码：4936-4941 , 文章类型： Article，,卷期：2011年17-15]
- Adult stem cells are maintained in a quiescent state but are able to exit quiescence and rapidly expand and differentiate in response to stress. The quiescent state appears to be necessary for preserving the self-renewal...
- Cancer Stem Cells and Chemosensitivity
[作者：Maugeri-Sacca, M; Vigneri, P; De Maria, R,期刊：Clinical Cancer Research, 页码：4942-4947 , 文章类型： Article，,卷期：2011年17-15]
- Cancer lethality is mainly due to the onset of distant metastases and refractoriness to chemotherapy. Thus, the development of molecular targeted agents that can restore or increase chemosensitivity will provide valuable...
- Targeting GPCR-Mediated p70S6K Activity May Improve Head and Neck Cancer Response to Cetuximab
[作者：Bhola, NE; Thomas, SM; Freilino, M; Joyce, S; Sahu, A; Maxwell, J; Argiris, A; Seethala, R; Grandis, JR,期刊：Clinical Cancer Research, 页码：4996-5004 , 文章类型： Article，,卷期：2011年17-15]
- Purpose: Epidermal growth factor receptor (EGFR) overexpression is correlated with decreased survival in head and neck cancer (HNC) where the addition of EGFR inhibition to standard chemoradiation approaches has improved...
- Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma
[作者：Kubo, T; Toyooka, S; Tsukuda, K; Sakaguchi, M; Fukazawa, T; Soh, J; Asano, H; Ueno, T; Muraoka, T; Yamamoto, H; Nasu, Y; Kishimoto, T; Pass, HI; Matsui, H; Huh, N; Miyoshi, S,期刊：Clinical Cancer Research, 页码：4965-4974 , 文章类型： Article，,卷期：2011年17-15]
- Purpose: Malignant pleural mesothelioma (MPM) is an aggressive tumor with a dismal prognosis. Unlike other malignancies, TP53 mutations are rare in MPM. Recent studies have showed that altered expression of microRNA (miR...
- Interleukin-7 Inhibits Tumor-Induced CD27(-)CD28(-) Suppressor T Cells: Implications for Cancer Immunotherapy
[作者：Zhang, Y; Pfannenstiel, LW; Bolesta, E; Montes, CL; Zhang, XY; Chapoval, AI; Gartenhaus, RB; Strome, SE; Gastman, BR,期刊：Clinical Cancer Research, 页码：4975-4986 , 文章类型： Article，,卷期：2011年17-15]
- Purpose: We have previously reported that many types of tumors can induce changes in human T cells that lead to the acquisition of suppressive function and phenotypic alterations resembling those found in senescent T cel...
- Adoptive Transfer of Tumor Reactive B Cells Confers Host T-Cell Immunity and Tumor Regression
[作者：Li, Q; Lao, XM; Pan, Q; Ning, N; Yet, J; Xu, YX; Li, SP; Chang, AE,期刊：Clinical Cancer Research, 页码：4987-4995 , 文章类型： Article，,卷期：2011年17-15]
- Purpose: We investigated the antitumor reactivity of adoptively transferred effector B cells and the mechanisms by which they may mediate tumor regression in a spontaneous metastases model. Experimental Design: 4T1 breas...
- Treatment-Induced Oxidative Stress and Cellular Antioxidant Capacity Determine Response to Bortezomib in Mantle Cell Lymphoma
[作者：Weniger, MA; Rizzatti, EG; Perez-Galan, P; Liu, DL; Wang, QY; Munson, PJ; Raghavachari, N; White, T; Tweito, MM; Dunleavy, K; Ye, YH; Wilson, WH; Wiestner, A,期刊：Clinical Cancer Research, 页码：5101-5112 , 文章类型： Article，,卷期：2011年17-15]
- Purpose: Proteasome inhibition disrupts protein homeostasis and induces apoptosis. Up to 50% of patients with relapsed mantle cell lymphoma (MCL) respond to bortezomib. We used gene expression profiling to investigate th...
- Pertuzumab in Combination with Trastuzumab Shows Significantly Enhanced Antitumor Activity in HER2-Positive Human Gastric Cancer Xenograft Models
[作者：Yamashita-Kashima, Y; Iijima, S; Yorozu, K; Furugaki, K; Kurasawa, M; Ohta, M; Fujimoto-Ouchi, K,期刊：Clinical Cancer Research, 页码：5060-5070 , 文章类型： Article，,卷期：2011年17-15]
- Purpose: We investigated the antitumor activity of the combination of two different humanized monoclonal human epidermal growth factor receptor (HER) 2 antibodies, pertuzumab and trastuzumab, for gastric cancer. Experime...
- Phase I and Pharmacokinetic Study of Sunitinib in Pediatric Patients with Refractory Solid Tumors: A Children's Oncology Group Study
[作者：DuBois, SG; Shusterman, S; Ingle, AM; Ahern, CH; Reid, JM; Wu, B; Baruchel, S; Glade-Bender, J; Ivy, P; Grier, HE; Adamson, PC; Blaney, SM,期刊：Clinical Cancer Research, 页码：5113-5122 , 文章类型： Article，,卷期：2011年17-15]
- Purpose: Sunitinib is an oral multitargeted receptor tyrosine kinase inhibitor. The purpose of this study was to determine the recommended phase 2 dose, pharmacokinetics, pharmacodynamic effects, and preliminary antitumo...
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