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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共33条记录   miR-22 Promotes HBV-Related Hepatocellular Carcinoma Development in Males [作者：Jiang, RQ; Deng, L; Zhao, L; Li, XC; Zhang, F; Xia, YX; Gao, Y; Wang, XH; Sun, BC,期刊：Clinical Cancer Research, 页码：5593-5603 , 文章类型： Article，,卷期：2011年17-17] Purpose: Previous reports have shown that IL-1 alpha-MyD88-IL- 6 signaling is essential in promoting hepatocellular carcinoma (HCC) development in a diethylnitrosamine (DEN)- induced mouse model. We aimed to determine wh... The Novel HSP90 Inhibitor, IPI-493, Is Highly Effective in Human Gastrostrointestinal Stromal Tumor Xenografts Carrying Heterogeneous KIT Mutations [作者：Floris, G; Sciot, R; Wozniak, A; Van Looy, T; Wellens, J; Faa, G; Normant, E; Debiec-Rychter, M; Schoffski, P,期刊：Clinical Cancer Research, 页码：5604-5614 , 文章类型： Article，,卷期：2011年17-17] Purpose: KIT activity is crucial for gastrointestinal stromal tumors (GIST). Imatinib (IMA) and sunitinib (SUN) are very effective KIT-inhibitors in patients with advanced GIST but have no curative potential. We evaluate... PRAME-Specific Allo-HLA-Restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-Cell Receptor Gene Transfer [作者：Amir, AL; van der Steen, DM; van Loenen, MM; Hagedoorn, RS; de Boer, R; Kester, MDG; de Ru, AH; Lugthart, GJ; van Kooten, C; Hiemstra, PS; Jedema, I; Griffioen, M; van Veelen, PA; Falkenburg, JHF; Heemskerk, MHM,期刊：Clinical Cancer Research, 页码：5615-5625 , 文章类型： Article，,卷期：2011年17-17] Purpose: In human leukocyte antigen (HLA)-matched stem cell transplantation (SCT), it has been shown that beneficial immune response mediating graft-versus-tumor (GVT) responses can be separated from graft-versus-host di... microRNA-10b: A New Marker or the Marker of Pancreatic Ductal Adenocarcinoma? [作者：Setoyama, T; Zhang, XN; Natsugoe, S; Calin, GA,期刊：Clinical Cancer Research, 页码：5527-5529 , 文章类型： Article，,卷期：2011年17-17] microRNA-10b (miR-10b) expression in pancreatic ductal adenocarcinoma (PDAC), as identified by in situ hybridization, is highly correlated with cancer diagnosis, therapy response, and prognosis. If these findings are fur... New Strategies in Overcoming Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer [作者：Oxnard, GR; Arcila, ME; Chmielecki, J; Ladanyi, M; Miller, VA; Pao, W,期刊：Clinical Cancer Research, 页码：5530-5537 , 文章类型： Article，,卷期：2011年17-17] The management of non-small cell lung carcinoma (NSCLC) has been transformed by the observation that lung adenocarcinomas harboring mutations in epidermal growth factor receptor (EGFR) are uniquely sensitive to EGFR tyro... Phase II Trials Powered to Detect Tumor Subtypes [作者：Roberts, JD; Ramakrishnan, V,期刊：Clinical Cancer Research, 页码：5538-5545 , 文章类型： Article，,卷期：2011年17-17] Classical phase II trial designs, including "adaptive" designs, require the prospective characterization of tumors. We propose a 2-stage phase II design that allows for characterization of tumors and selection of a tumor... Inhibition of Src Family Kinases and Receptor Tyrosine Kinases by Dasatinib: Possible Combinations in Solid Tumors [作者：Montero, JC; Seoane, S; Ocana, A; Pandiella, A,期刊：Clinical Cancer Research, 页码：5546-5552 , 文章类型： Article，,卷期：2011年17-17] Dasatinib is a small molecule tyrosine kinase inhibitor that targets a wide variety of tyrosine kinases implicated in the pathophysiology of several neoplasias. Among the most sensitive dasatinib targets are ABL, the SRC... Hematopoietic Stem Cell Niche Is a Potential Therapeutic Target for Bone Metastatic Tumors [作者：Shiozawa, Y; Pienta, KJ; Taichman, RS,期刊：Clinical Cancer Research, 页码：5553-5558 , 文章类型： Article，,卷期：2011年17-17] Despite significant improvements in therapy, the prognosis for cancer with bone metastasis is generally poor. Therefore, there is a great need for new therapeutic approaches for metastatic disease. It has been appreciate... Optimizing Chemotherapy-Free Survival for the ER/HER2-Positive Metastatic Breast Cancer Patient [作者：Gluck, S; Arteaga, CL; Osborne, CK,期刊：Clinical Cancer Research, 页码：5559-5561 , 文章类型： Article，,卷期：2011年17-17] The recent incremental advances made in the treatment of metastatic breast cancer have elicited potential for survival extension in this treatable, yet incurable, population of breast cancer patients. Clinicians have foc... Molecular Characteristics of ERCC1-Negative versus ERCC1-Positive Tumors in Resected NSCLC [作者：Friboulet, L; Barrios-Gonzales, D; Commo, F; Olaussen, KA; Vagner, S; Adam, J; Goubar, A; Dorvault, N; Lazar, V; Job, B; Besse, B; Validire, P; Girard, P; Lacroix, L; Hasmats, J; Dufour, F; Andre, F; Soria, JC,期刊：Clinical Cancer Research, 页码：5562-5572 , 文章类型： Article，,卷期：2011年17-17] Purpose: Excision repair cross-complementation group 1 (ERCC1) is a protein involved in repair of DNA platinum adducts and stalled DNA replication forks. We and others have previously shown the influence of ERCC1 express... Telomere Attrition and Decreased Fetuin-A Levels Indicate Accelerated Biological Aging and Are Implicated in the Pathogenesis of Colorectal Cancer [作者：Maxwell, F; McGlynn, LM; Muir, HC; Talwar, D; Benzeval, M; Robertson, T; Roxburgh, CS; McMillan, DC; Horgan, PG; Shiels, PG,期刊：Clinical Cancer Research, 页码：5573-5581 , 文章类型： Article，,卷期：2011年17-17] Purpose: Increasing chronological age is a risk factor for many types of cancer including colorectal. An understanding of the biology of aging and factors which regulate it may provide insight into cancer pathogenesis. T... Comprehensive Genome Methylation Analysis in Bladder Cancer: Identification and Validation of Novel Methylated Genes and Application of These as Urinary Tumor Markers [作者：Reinert, T; Modin, C; Castano, FM; Lamy, P; Wojdacz, TK; Hansen, LL; Wiuf, C; Borre, M; Dyrskjot, L; Orntoft, TF,期刊：Clinical Cancer Research, 页码：5582-5592 , 文章类型： Article，,卷期：2011年17-17] Purpose: Epigenetic alterations are common and can now be addressed in a parallel fashion. We investigated the methylation in bladder cancer with respect to location in genome, consistency, variation in metachronous tumo... Cell Surface Delivery of TRAIL Strongly Augments the Tumoricidal Activity of T Cells [作者：de Bruyn, M; Wei, YW; Wiersma, VR; Samplonius, DF; Klip, HG; van der Zee, AGJ; Yang, BF; Helfrich, W; Bremer, E,期刊：Clinical Cancer Research, 页码：5626-5637 , 文章类型： Article，,卷期：2011年17-17] Purpose: Adoptive T-cell therapy generally fails to induce meaningful anticancer responses in patients with solid tumors. Here, we present a novel strategy designed to selectively enhance the tumoricidal activity of T ce... MK-1775, a Novel Wee1 Kinase Inhibitor, Radiosensitizes p53-Defective Human Tumor Cells [作者：Bridges, KA; Hirai, H; Buser, CA; Brooks, C; Liu, HF; Buchholz, TA; Molkentine, JM; Mason, KA; Meyn, RE,期刊：Clinical Cancer Research, 页码：5638-5648 , 文章类型： Article，,卷期：2011年17-17] Purpose: Radiotherapy is commonly used to treat a variety of solid tumors. However, improvements in the therapeutic ratio for several disease sites are sorely needed, leading us to assess molecularly targeted therapeutic... Nutlin-3 Downregulates the Expression of the Oncogene TCL1 in Primary B Chronic Lymphocytic Leukemic Cells [作者：Voltan, R; di Iasio, MG; Bosco, R; Valeri, N; Pekarski, Y; Tiribelli, M; Secchiero, P; Zauli, G,期刊：Clinical Cancer Research, 页码：5649-5655 , 文章类型： Article，,卷期：2011年17-17] Purpose: The oncogene TCL1 plays a key role in the development of B chronic lymphocytic leukemia (B-CLL), but it is not known whether TCL1 could be modulated by therapeutic approaches. Experimental Design: B-CLL patient ... Metronomic Oral Topotecan with Pazopanib Is an Active Antiangiogenic Regimen in Mouse Models of Aggressive Pediatric Solid Tumor [作者：Kumar, S; Mokhtari, RB; Sheikh, R; Wu, B; Zhang, LB; Xu, P; Man, S; Oliveira, ID; Yeger, H; Kerbel, RS; Baruchel, S,期刊：Clinical Cancer Research, 页码：5656-5667 , 文章类型： Article，,卷期：2011年17-17] Purpose: Low dose metronomic (LDM) chemotherapy, combined with VEGF signaling pathway inhibitors, is a highly effective strategy to coordinately inhibit angiogenesis and tumor growth in many adult preclinical cancer mode...