- Role of Smac in Determining the Chemotherapeutic Response of Esophageal Squamous Cell Carcinoma
[作者：Xu, Y; Zhou, LP; Huang, J; Liu, F; Yu, J; Zhan, QM; Zhang, L; Zhao, XH,期刊：Clinical Cancer Research, 页码：5412-5422 , 文章类型： Article，,卷期：2011年17-16]
- Purpose: Second mitochondria-derived activator of caspase (Smac) regulates chemotherapy-induced apoptosis. Smac mimetics have been tested in clinical trials as chemosensitizers. We determined the role of Smac in modulati...
- Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models
[作者：Yamanaka, K; Nakahara, T; Yamauchi, T; Kita, A; Takeuchi, M; Kiyonaga, F; Kaneko, N; Sasamata, M,期刊：Clinical Cancer Research, 页码：5423-5431 , 文章类型： Article，,卷期：2011年17-16]
- Purpose: Aggressive cell growth and chemoresistance are notorious obstacles in melanoma therapy. Accumulating evidence suggests that survivin is preferentially expressed in cancer cells and plays a crucial role in cell d...
- Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90
[作者：Mehta, PP; Whalen, P; Baxi, SM; Kung, PP; Yamazaki, S; Yin, MJ,期刊：Clinical Cancer Research, 页码：5432-5442 , 文章类型： Article，,卷期：2011年17-16]
- Purpose: Triple-negative breast cancer (TNBC) patients have poor prognoses and survival outcomes such that the development of new targeted therapies is in strong demand. Mechanisms associated with high proliferation and ...
- Prognostic Model for Survival in Patients with Metastatic Renal Cell Carcinoma: Results from the International Kidney Cancer Working Group
[作者：Manola, J; Royston, P; Elson, P; McCormack, JB; Mazumdar, M; Negrier, S; Escudier, B; Eisen, T; Dutcher, J; Atkins, M; Heng, DYC; Choueiri, TK; Motzer, R; Bukowski, R,期刊：Clinical Cancer Research, 页码：5443-5450 , 文章类型： Article，,卷期：2011年17-16]
- Purpose: To develop a single validated model for survival in metastatic renal cell carcinoma (mRCC) using a comprehensive international database. Experimental Design: A comprehensive database of 3,748 patients including ...
- Overcoming Antiangiogenic Resistance
[作者：Yao, JC; Phan, A,期刊：Clinical Cancer Research, 页码：5217-5219 , 文章类型： Editorial Material，,卷期：2011年17-16]
- The success of drugs targeting angiogenesis is tempered by the transient duration of disease control and modest survival improvement. The very hypoxic stress produced by successful therapy may lead to upregulation of mul...
- Gene Expression Profiling of Fixed Tissues Identified Hypoxia-Inducible Factor-1 alpha, VEGF, and Matrix Metalloproteinase-2 as Biomarkers of Lymph Node Metastasis in Hepatocellular Carcinoma
[作者：Xiang, ZL; Zeng, ZC; Fan, J; Tang, ZY; Zeng, HY; Gao, DM,期刊：Clinical Cancer Research, 页码：5463-5472 , 文章类型： Article，,卷期：2011年17-16]
- Purpose: Hepatocellular carcinoma (HCC) most often develops in patients infected with hepatitis B or hepatitis C virus. Differential gene expression profiling is useful for investigating genes associated with lymph node ...
- The European Medicines Agency: An Overview of Its Mission, Responsibilities, and Recent Initiatives in Cancer Drug Regulation
[作者：Pignatti, F; Gravanis, I; Herold, R; Vamvakas, S; Jonsson, B; Marty, M,期刊：Clinical Cancer Research, 页码：5220-5225 , 文章类型： Article，,卷期：2011年17-16]
- The European Medicines Agency (EMA) is responsible for the scientific evaluation of medicines developed by pharmaceutical companies for use in the European Union (EU). Since 2005, the agency has become responsible for th...
- Angiopoietin-2 TIEs Up Macrophages in Tumor Angiogenesis
[作者：De Palma, M; Naldini, L,期刊：Clinical Cancer Research, 页码：5226-5232 , 文章类型： Article，,卷期：2011年17-16]
- Angiopoietin-2 (ANG2), a ligand of the TIE2 receptor, modulates endothelial cell biology and destabilizes blood vessels to facilitate angiogenesis. Recent reports have shown that ANG2 inhibition, for example, by monoclon...
- Prostate Cancer Immunotherapy
[作者：May, KF; Gulley, JL; Drake, CG; Dranoff, G; Kantoff, PW,期刊：Clinical Cancer Research, 页码：5233-5238 , 文章类型： Article，,卷期：2011年17-16]
- The interaction between the immune system and prostate cancer has been an area of research interest for several decades. The recent U. S. Food and Drug Administration approval of 2 first-in-class proof-of-concept immunot...
- SWOG Cooperative Group Biorepository Resource: Access for Scientific Research Studies
[作者：Hoban, CJ; Franklin, WA; Kopecky, KJ; Baker, LH,期刊：Clinical Cancer Research, 页码：5239-5246 , 文章类型： Article，,卷期：2011年17-16]
- SWOG (formerly the Southwest Oncology Group), a National Cancer Institute-supported cooperative group, conducts multi-institutional, multidisciplinary clinical trials for adult patients with cancer, covering a wide range...
- Prognostic Immune Markers in Non-Small Cell Lung Cancer
[作者：Suzuki, K; Kachala, SS; Kadota, K; Shen, RL; Mo, QX; Beer, DG; Rusch, VW; Travis, WD; Adusumilli, PS,期刊：Clinical Cancer Research, 页码：5247-5256 , 文章类型： Review，,卷期：2011年17-16]
- Tumor-associated immune responses have polarized effects in regulating tumor growth. Although a clear association has been shown between the tumor immune response and clinical outcome in colorectal and ovarian cancers, t...
- Novel Functional Germline Variants in the VEGF Receptor 2 Gene and Their Effect on Gene Expression and Microvessel Density in Lung Cancer
[作者：Glubb, DM; Cerri, E; Giese, A; Zhang, W; Mirza, O; Thompson, EE; Chen, PX; Das, S; Jassem, J; Rzyman, W; Lingen, MW; Salgia, R; Hirsch, FR; Dziadziuszko, R; Ballmer-Hofer, K; Innocenti, F,期刊：Clinical Cancer Research, 页码：5257-5267 , 文章类型： Article，,卷期：2011年17-16]
- Purpose: VEGF receptor 2 (VEGFR-2) plays a crucial role in mediating angiogenic endothelial cell responses via the VEGF pathway, and angiogenesis inhibitors targeting VEGFR-2 are in clinical use. As angiogenesis is a hos...
- Clonal Relationship of Classical Hodgkin Lymphoma and Its Recurrences
[作者：Obermann, EC; Mueller, N; Rufle, A; Menter, T; Mueller-Garamvoelgyi, E; Cathomas, G; Dirnhofer, S; Tzankov, A,期刊：Clinical Cancer Research, 页码：5268-5274 , 文章类型： Article，,卷期：2011年17-16]
- Purpose: We investigated whether the first and all subsequent manifestations of Hodgkin lymphoma (HL) in a patient are clonally related. Experimental Design: We identified a collective of 20 patients with sometimes multi...
- FGFR Signaling Promotes the Growth of Triple-Negative and Basal-Like Breast Cancer Cell Lines Both In Vitro and In Vivo
[作者：Sharpe, R; Pearson, A; Herrera-Abreu, MT; Johnson, D; Mackay, A; Welti, JC; Natrajan, R; Reynolds, AR; Reis, JS; Ashworth, A; Turner, NC,期刊：Clinical Cancer Research, 页码：5275-5286 , 文章类型： Article，,卷期：2011年17-16]
- Purpose: The oncogenic drivers of triple-negative (TN) and basal-like breast cancers are largely unknown. Substantial evidence now links aberrant signaling by the fibroblast growth factor receptors (FGFR) to the developm...
- Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis
[作者：Saini, S; Majid, S; Yamamura, S; Tabatabai, L; Suh, SO; Shahryari, V; Chen, Y; Deng, GR; Tanaka, Y; Dahiya, R,期刊：Clinical Cancer Research, 页码：5287-5298 , 文章类型： Article，,卷期：2011年17-16]
- Purpose: Advanced metastatic prostate cancer (PCa) is a fatal disease, with only palliative therapeutic options. Though almost 80% of cases of metastatic PCa present bone metastasis, our current understanding of the mole...
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