- c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4(+) T-Cell Differentiation and Allergic Lung Inflammation
[作者:Chen, A; Lee, SM; Gao, BX; Shannon, S; Zhu, Z; Fang, DY,期刊:Molecular and Cellular Biology, 页码:3445-3456 , 文章类型: Article,,卷期:2011年31-16]
- The tyrosine kinase c-Abl is required for full activation of T cells, while its role in T-cell differentiation has not been characterized. We report that c-Abl deficiency skews CD4(+) T cells to type 2 helper T cell (Th2...
- Molecular Chaperone Hsp90 Regulates REV1-Mediated Mutagenesis
[作者:Pozo, FM; Oda, T; Sekimoto, T; Murakumo, Y; Masutani, C; Hanaoka, F; Yamashita, T,期刊:Molecular and Cellular Biology, 页码:3396-3409 , 文章类型: Article,,卷期:2011年31-16]
- REV1 is a Y-family polymerase that plays a central role in mutagenic translesion DNA synthesis (TLS), contributing to tumor initiation and progression. In a current model, a monoubiquitinated form of the replication acce...
- Cdc25A Regulates Matrix Metalloprotease 1 through Foxo1 and Mediates Metastasis of Breast Cancer Cells
[作者:Feng, XL; Wu, ZJ; Wu, YS; Hankey, W; Prior, TW; Li, L; Ganju, RK; Shen, RL; Zou, XH,期刊:Molecular and Cellular Biology, 页码:3457-3471 , 文章类型: Article,,卷期:2011年31-16]
- Cdc25A is a cell cycle-activating phosphatase, and its overexpression in breast cancers has been shown to correlate with poor prognosis. Most recent studies related to Cdc25A and tumor progression have focused on its rol...
- Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic beta-Type Globin Promoters in Differentiated Adult Erythroid Cells
[作者:Cui, SAY; Kolodziej, KE; Obara, N; Amaral-Psarris, A; Demmers, J; Shi, LH; Engel, JD; Grosveld, F; Strouboulis, J; Tanabe, O,期刊:Molecular and Cellular Biology, 页码:3298-3311 , 文章类型: Article,,卷期:2011年31-16]
- Nuclear receptors TR2 and TR4 (TR2/TR4) were previously shown to bind in vitro to direct repeat elements in the mouse and human embryonic and fetal beta-type globin gene promoters and to play critical roles in the silenc...
- Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter
[作者:Lu, YH; Chu, A; Turker, MS; Glazer, PM,期刊:Molecular and Cellular Biology, 页码:3339-3350 , 文章类型: Article,,卷期:2011年31-16]
- Disruption of the BRCA1 tumor suppressor can be caused not only by inherited mutations in familial cancers but also by BRCA1 gene silencing in sporadic cancers. Hypoxia, a key feature of the tumor microenvironment, has b...
- Identification of Heat Shock Factor 1 Molecular and Cellular Targets during Embryonic and Adult Female Meiosis
[作者:Le Masson, F; Razak, Z; Kaigo, M; Audouard, C; Charry, C; Cooke, H; Westwood, JT; Christians, ES,期刊:Molecular and Cellular Biology, 页码:3410-3423 , 文章类型: Article,,卷期:2011年31-16]
- Heat shock factor 1 (HSF1), while recognized as the major regulator of the heat shock transcriptional response, also exerts important functions during mammalian embryonic development and gametogenesis. In particular, HSF...
- CrbpI Modulates Glucose Homeostasis and Pancreas 9-cis-Retinoic Acid Concentrations
[作者:Kane, MA; Folias, AE; Pingitore, A; Perri, M; Krois, CR; Ryu, JY; Cione, E; Napoli, JL,期刊:Molecular and Cellular Biology, 页码:3277-3285 , 文章类型: Article,,卷期:2011年31-16]
- Cellular retinol-binding protein type I (CrbpI), encoded by Rpb1, serves as a chaperone of retinol homeostasis, but its physiological effects remain incompletely understood. We show here that the Rbp1(-/-) mouse has disr...
- Posttranscriptional Control of Type I Interferon Genes by KSRP in the Innate Immune Response against Viral Infection
[作者:Lin, WJ; Zheng, XJ; Lin, CC; Tsao, J; Zhu, XL; Cody, JJ; Coleman, JM; Gherzi, R; Luo, M; Townes, TM; Parker, JN; Chen, CY,期刊:Molecular and Cellular Biology, 页码:3196-3207 , 文章类型: Article,,卷期:2011年31-16]
- Inherently unstable mRNAs contain AU-rich elements (AREs) in the 3' untranslated regions. Expression of ARE-containing type I interferon transcripts is robustly induced upon viral infection and rapidly shut off thereafte...
- Prevention of Transcriptional Silencing by a Replicator-Binding Complex Consisting of SWI/SNF, MeCP1, and hnRNP C1/C2
[作者:Huang, L; Fu, HQ; Lin, CM; Conner, AL; Zhang, Y; Aladjem, MI,期刊:Molecular and Cellular Biology, 页码:3472-3484 , 文章类型: Article,,卷期:2011年31-16]
- Transcriptional silencing selectively impedes gene expression. Silencing is often accompanied by replication delay and can be prevented by replicator sequences. Here we report a replicator-binding protein complex involve...
- PINCH Proteins Regulate Cardiac Contractility by Modulating Integrin-Linked Kinase-Protein Kinase B Signaling
[作者:Meder, B; Huttner, IG; Sedaghat-Hamedani, F; Just, S; Dahme, T; Frese, KS; Vogel, B; Kohler, D; Kloos, W; Rudloff, J; Marquart, S; Katus, HA; Rottbauer, W,期刊:Molecular and Cellular Biology, 页码:3424-3435 , 文章类型: Article,,卷期:2011年31-16]
- Integrin-linked kinase (ILK) is an essential component of the cardiac mechanical stretch sensor and is bound in a protein complex with parvin and PINCH proteins, the so-called ILK-PINCH-parvin (IPP) complex. We have rece...
- Severe Alterations of Cerebellar Cortical Development after Constitutive Activation of Wnt Signaling in Granule Neuron Precursors
[作者:Lorenz, A; Deutschmann, M; Ahlfeld, J; Prix, C; Koch, A; Smits, R; Fodde, R; Kretzschmar, HA; Schuller, U,期刊:Molecular and Cellular Biology, 页码:3326-3338 , 文章类型: Article,,卷期:2011年31-16]
- The Wnt/beta-catenin signaling pathway plays crucial roles in early hindbrain formation, and its constitutive activity is associated with a subset of human medulloblastoma, a malignant childhood tumor of the posterior fo...
- Talin1 Regulates Integrin Turnover To Promote Embryonic Epithelial Morphogenesis
[作者:Liu, J; He, XW; Qi, YM; Tian, XX; Monkley, SJ; Critchley, DR; Corbett, SA; Lowry, SF; Graham, AM; Li, SH,期刊:Molecular and Cellular Biology, 页码:3366-3377 , 文章类型: Article,,卷期:2011年31-16]
- Talin is a cytoskeletal protein that binds to integrin beta cytoplasmic tails and regulates integrin activation. Talin1 ablation in mice disrupts gastrulation and causes embryonic lethality. However, the role of talin in...
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