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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Sealing the Envelope-the HIV-1 Envelope Glycoproteins as Targets for Therapeutics and Vaccines [作者：Sanders, RW; Berkhout, B,期刊：Current Pharmaceutical Design, 页码：3699-3700 , 文章类型： Editorial Material，,卷期：2010年16-33] HIV-1 (co)Receptors: Implications for Vaccine and Therapy Design [作者：Pollakis, G; Paxton, WA,期刊：Current Pharmaceutical Design, 页码：3701-3715 , 文章类型： Review，,卷期：2010年16-33] The ultimate aim of therapy or vaccine design against HIV is to eliminate ongoing virus replication or prevent HIV infection. The task at hand is daunting given the wide array of HIV variants circulating and the immense ... Implications of Melatonin Therapy in Irritable Bowel Syndrome: A Systematic Review [作者：Mozaffari, S; Rahimi, R; Abdollahi, M,期刊：Current Pharmaceutical Design, 页码：3646-3655 , 文章类型： Review，,卷期：2010年16-33] Irritable bowel syndrome (IBS) is a highly prevalent chronic functional gastrointestinal (GI) disorder associated with abdominal pain and change in bowel habits that its etiology is not known yet. In the recent years, me... Antibody Epitope Exposure and Neutralization of HIV-1 [作者：Pantophlet, RA,期刊：Current Pharmaceutical Design, 页码：3729-3743 , 文章类型： Review，,卷期：2010年16-33] Formulating an effective HIV vaccine remains a formidable challenge despite nearly 3 decades of intense research since the virus was first isolated. One of the obstacles that need to be surmounted is the design of a prep... Inhibition of HIV-1 by Fusion Inhibitors [作者：Eggink, D; Berkhout, B; Sanders, RW,期刊：Current Pharmaceutical Design, 页码：3716-3728 , 文章类型： Review，,卷期：2010年16-33] The envelope glycoprotein complex (Env) is responsible for entry of the human immunodeficiency virus type 1 (HIV-1) into cells by mediating attachment to target cells and subsequent membrane fusion. Env consists of three... Current Developments for the Diagnosis and Treatment of Irritable Bowel Syndrome [作者：Grundmann, O; Yoon, SL; Moshiree, B,期刊：Current Pharmaceutical Design, 页码：3638-3645 , 文章类型： Review，,卷期：2010年16-33] Current treatment options for the chronic gastrointestinal disorder irritable bowel syndrome (IBS) have long been limited to symptomatic treatments due to lack of pathophysiologic understanding of the syndrome. Within th... Current Therapeutic Approaches in Inflammatory Bowel Disease [作者：Sohrabpour, AA; Malekzadeh, R; Keshavarzian, A,期刊：Current Pharmaceutical Design, 页码：3668-3683 , 文章类型： Review，,卷期：2010年16-33] Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory disorder of the gastrointestinal tract and is broadly classified into Crohn's disease (CD) and ulcerative colitis (UC). In the last decade, our under... Phosphodiesterase 4 Inhibitors in Inflammatory Bowel Disease: A Comprehensive Review [作者：Salari-Sharif, P; Abdollahi, M,期刊：Current Pharmaceutical Design, 页码：3661-3667 , 文章类型： Review，,卷期：2010年16-33] Inflammatory bowel disease (IBD) is known as a chronic inflammation of gastrointestinal tract that its pathogenesis still is not completely understood. Several drug categories are used for management of IBD but there is ... Efficacy and Tolerability of Immunoregulators and Antibiotics in Fistulizing Crohn's Disease: A Systematic Review and Meta-analysis of Placebo-controlled Trials [作者：Nikfar, S; Mirfazaelian, H; Abdollahi, M,期刊：Current Pharmaceutical Design, 页码：3684-3698 , 文章类型： Review，,卷期：2010年16-33] Objective: This meta-analysis of randomized controlled trials was conducted to evaluate the efficacy and tolerability of two drug groups (immunoregulators and antibiotics) in the treatment of fistula in Crohn's disease (... Structure-based Vaccine Design in HIV: Blind Men and the Elephant? [作者：Pejchal, R; Wilson, IA,期刊：Current Pharmaceutical Design, 页码：3744-3753 , 文章类型： Review，,卷期：2010年16-33] Traditional vaccine approaches have failed for HIV and novel strategies are now being sought to develop immunogens designed to elicit specific activity against known broad neutralization epitopes. Structure-based vaccine... Targeting IL-23 and Th17-Cytokines in Inflammatory Bowel Diseases [作者：De Nitto, D; Sarra, M; Cupi, ML; Pallone, F; Monteleone, G,期刊：Current Pharmaceutical Design, 页码：3656-3660 , 文章类型： Review，,卷期：2010年16-33] Over the last 15 years, the use of various biological therapies has largely improved the way we manage patients with Inflammatory Bowel Diseases (IBDs). Blockade of cytokine synthesis and/or activity is at the forefront ... Therapeutic Antibodies in HIV Treatment - Classical Approaches to Novel Advances [作者：Abela, IA; Reynell, L; Trkola, A,期刊：Current Pharmaceutical Design, 页码：3754-3766 , 文章类型： Review，,卷期：2010年16-33] Therapeutic antibodies have evolved into an important drug class and have achieved considerable success in combating cancers and autoimmune diseases. Although their potential in the treatment of viral infections has not ...