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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Unveiled alpha-Neurexins Take Center Stage [作者：Reissner, C; Missler, M,期刊：Structure, 页码：749-750 , 文章类型： Editorial Material，,卷期：2011年19-6] Recombining DNA by Protein Swivels [作者：Johnson, RC; McLean, MM,期刊：Structure, 页码：751-753 , 文章类型： Editorial Material，,卷期：2011年19-6] Structural Changes Underlying Allostery in Group II Chaperonins [作者：Willison, KR,期刊：Structure, 页码：754-755 , 文章类型： Editorial Material，,卷期：2011年19-6] Improved Technologies Now Routinely Provide Protein NMR Structures Useful for Molecular Replacement [作者：Mao, BC; Guan, RJ; Montelione, GT,期刊：Structure, 页码：757-766 , 文章类型： Article，,卷期：2011年19-6] Molecular replacement (MR) is widely used for addressing the phase problem in X-ray crystallography. Historically, crystallographers have had limited success using NMR structures as MR search models. Here, we report a co... The Structure of Neurexin 1 alpha Reveals Features Promoting a Role as Synaptic Organizer [作者：Chen, F; Venugopal, V; Murray, B; Rudenko, G,期刊：Structure, 页码：779-789 , 文章类型： Article，,卷期：2011年19-6] alpha-Neurexins are essential synaptic adhesion molecules implicated in autism spectrum disorder and schizophrenia. The alpha-neurexin extracellular domain consists of six LNS domains interspersed by three EGF-like repea... The Deletion of Exon 3 in the Cardiac Ryanodine Receptor Is Rescued by beta Strand Switching [作者：Lobo, PA; Kimlicka, L; Tung, CC; Van Petegem, F,期刊：Structure, 页码：790-798 , 文章类型： Article，,卷期：2011年19-6] Mutations in the cardiac Ryanodine Receptor (RYR2) are linked to triggered arrhythmias. Removal of exon 3 results in a severe form of catecholaminergic polymorphic ventricular tachycardia (CPVT). This exon encodes second... The Crystal Structure of the alpha-Neurexin-1 Extracellular Region Reveals a Hinge Point for Mediating Synaptic Adhesion and Function [作者：Miller, MT; Mileni, M; Comoletti, D; Stevens, RC; Harel, M; Taylori, P,期刊：Structure, 页码：767-778 , 文章类型： Article，,卷期：2011年19-6] alpha- and beta-neurexins (NRXNs) are transmembrane cell adhesion proteins that localize to presynaptic membranes in neurons and interact with the postsynaptic neuroligins (NLGNs). Their gene mutations are associated wit... Domain Orientation in the N-Terminal PDZ Tandem from PSD-95 Is Maintained in the Full-Length Protein [作者：McCann, JJ; Zheng, LQ; Chiantia, S; Bowen, ME,期刊：Structure, 页码：810-820 , 文章类型： Article，,卷期：2011年19-6] Tandem PDZ domains have been suggested to form structurally independent supramodules. However, dissimilarity between crystallography and NMR models emphasize their malleable conformation. Studies in full-length scaffold ... Implications for Damage Recognition during Dpo4-Mediated Mutagenic Bypass of m1G and m3C Lesions [作者：Rechkoblit, O; Delaney, JC; Essigmann, JM; Patel, DJ,期刊：Structure, 页码：821-832 , 文章类型： Article，,卷期：2011年19-6] DNA is susceptible to alkylation damage by a number of environmental agents that modify the Watson-Crick edge of the bases. Such lesions, if not repaired, may be bypassed by Y-family DNA polymerases. The bypass polymeras... Structural Basis for Catalytic Activation of a Serine Recombinase [作者：Keenholtz, RA; Rowland, SJ; Boocock, MR; Stark, WM; Rice, PA,期刊：Structure, 页码：799-809 , 文章类型： Article，,卷期：2011年19-6] Sin resolvase is a site-specific serine recombinase that is normally controlled by a complex regulatory mechanism. A single mutation, Q115R, allows the enzyme to bypass the entire regulatory apparatus, such that no acces... Hierarchical Binding of Cofactors to the AAA ATPase p97 [作者：Hanzelmann, P; Buchberger, A; Schindelin, H,期刊：Structure, 页码：833-843 , 文章类型： Article，,卷期：2011年19-6] The hexameric AAA ATPase p97 is involved in several human proteinopathies and mediates ubiquitin-dependent protein degradation among other essential cellular processes. Via its N-terminal domain (N domain), p97 interacts... A Smoothed Backbone-Dependent Rotamer Library for Proteins Derived from Adaptive Kernel Density Estimates and Regressions [作者：Shapovalov, MV; Dunbrack, RL,期刊：Structure, 页码：844-858 , 文章类型： Article，,卷期：2011年19-6] Rotamer libraries are used in protein structure determination, prediction, and design. The backbone-dependent rotamer library consists of rotamer frequencies, mean dihedral angles, and variances as a function of the back... Relative Solvent Accessible Surface Area Predicts Protein Conformational Changes upon Binding [作者：Marsh, JA; Teichmann, SA,期刊：Structure, 页码：859-867 , 文章类型： Article，,卷期：2011年19-6] Protein interactions are often accompanied by significant changes in conformation. We have analyzed the relationships between protein structures and the conformational changes they undergo upon binding. Based upon this, ... The Cap-Binding Translation Initiation Factor, elF4E, Binds a Pseudoknot in a Viral Cap-Independent Translation Element [作者：Wang, ZH; Parisien, M; Scheets, K; Miller, WA,期刊：Structure, 页码：868-880 , 文章类型： Article，,卷期：2011年19-6] Eukaryotic initiation factor elF4E performs a key early step in translation by specifically recognizing the m 7 GpppN cap structure at the 5' end of cellular mRNAs. Many viral mRNAs lack a 5' cap and thus bypass elF4E. I... Fine Details of IGF-1R Activation, Inhibition, and Asymmetry Determined by Associated Hydrogen/Deuterium-Exchange and Peptide Mass Mapping [作者：Houde, D; Demarest, SJ,期刊：Structure, 页码：890-900 , 文章类型： Article，,卷期：2011年19-6] The structural features of the asymmetric activated states of the insulin receptor family are still poorly understood. We investigated hydrogen/deuterium (H/D)-exchange within the extracellular domain of the type-I insul... A Systematic Study of the Energetics Involved in Structural Changes upon Association and Connectivity in Protein Interaction Networks [作者：Stein, A; Rueda, M; Panjkovich, A; Orozco, M; Aloy, P,期刊：Structure, 页码：881-889 , 文章类型： Article，,卷期：2011年19-6] The study of protein binding mechanisms is a major topic of research in structural biology. Here, we implement a combination of metrics to systematically assess the cost of backbone conformational changes that protein do...