个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   A Nervous Hedgehog Rolls into the Hair Follicle Stem Cell Scene [作者：Gordon, W; Andersen, B,期刊：Cell Stem Cell, 页码：459-460 , 文章类型： Editorial Material，,卷期：2011年8-5] In this issue of Cell Stem Cell, Brownell et al. (2011) identify stem cells in the hair follicle bulge that receive Hedgehog signals from adjacent sensory nerves. These stem cells regenerate the cycling hair follicle and... Human Induced Pluripotent Stem Cells: A New Model for Schizophrenia? [作者：Buxbaum, JD; Sklar, P,期刊：Cell Stem Cell, 页码：461-462 , 文章类型： Editorial Material，,卷期：2011年8-5] Lack of patient tissue and relevant disease models have constrained progress toward discovering the causes of schizophrenia. Recently in Nature, Brennand et al. (2011) reprogram schizophrenia patient fibroblasts to deriv... An Epigenetic Mark that Protects the Epithelial Phenotype in Health and Disease [作者：Heredia, F; Nieto, MA,期刊：Cell Stem Cell, 页码：462-463 , 文章类型： Editorial Material，,卷期：2011年8-5] Epithelial plasticity is crucial during embryonic development and progression of carcinomas. In this issue, Abell et al. (2011) show that acetylation on histones H2A/H2B prevents epithelial cells from undergoing epitheli... Neural Stem Cells: Disposable, End-State Glia? [作者：Lugert, S; Taylor, V,期刊：Cell Stem Cell, 页码：464-465 , 文章类型： Editorial Material，,卷期：2011年8-5] Neurogenesis in the brain diminishes with age. In this issue of Cell Stem C ell, Encinas et al. (2011) demonstrate that some hippocampal stem cells not only generate neurons, but also generate astrocytes in a mechanism t... Patient Advocates: Advancing Research from outside the Lab [作者：Davison, AC,期刊：Cell Stem Cell, 页码：466-467 , 文章类型： News Item，,卷期：2011年8-5] Target Populations for First-In-Human Embryonic Stem Cell Research in Spinal Cord Injury [作者：Bretzner, F; Gilbert, F; Baylis, F; Brownstone, RM,期刊：Cell Stem Cell, 页码：468-475 , 文章类型： Article，,卷期：2011年8-5] Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs). This trial raises important questions regarding ... Response to Frederic Bretzner et al. "Target Populations for First-In-Human Embryonic Stem Cell Research in Spinal Cord Injury" [作者：Wirth, E; Lebkowski, JS; Lebacqz, K,期刊：Cell Stem Cell, 页码：476-478 , 文章类型： Editorial Material，,卷期：2011年8-5] We address concerns raised in this issue by Bretzner et al. (2011) by explaining the rationale for including subjects with subacute, neurologically complete spinal cord injuries in the Phase 1 trial of GRNOPC1. We also p... The Tragedy of Translation: The Case of "First Use" in Human Embryonic Stem Cell Research [作者：Solbakk, JH; Zoloth, L,期刊：Cell Stem Cell, 页码：479-481 , 文章类型： Editorial Material，,卷期：2011年8-5] Who should go first in phase-I human trials when neither risks nor benefits can be estimated? By assessing concerns raised by Bretzner et al. (2011), we highlight a tragic dimension underlying all such trials. We discuss... Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment [作者：Lathia, JD; Heddleston, JM; Venere, M; Rich, JN,期刊：Cell Stem Cell, 页码：482-485 , 文章类型： Review，,卷期：2011年8-5] Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic networks and the niche microenvironment. ... Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells [作者：Pastrana, E; Silva-Vargas, V; Doetsch, F,期刊：Cell Stem Cell, 页码：486-498 , 文章类型： Review，,卷期：2011年8-5] Sphere-forming assays have been widely used to retrospectively identify stem cells based on their reported capacity to evaluate self-renewal and differentiation at the single-cell level in vitro. The discovery of markers... Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging [作者：Norddahl, GL; Pronk, CJ; Wahlestedt, M; Sten, G; Nygren, JM; Ugale, A; Sigvardsson, M; Bryder, D,期刊：Cell Stem Cell, 页码：499-510 , 文章类型： Article，,卷期：2011年8-5] Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function w... The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse [作者：Merlos-Suarez, A; Barriga, FM; Jung, P; Iglesias, M; Cespedes, MV; Rossell, D; Sevillano, M; Hernando-Momblona, X; da Silva-Diz, V; Munoz, P; Clevers, H; Sancho, E; Mangues, R; Batlle, E,期刊：Cell Stem Cell, 页码：511-524 , 文章类型： Article，,卷期：2011年8-5] A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patient... MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells [作者：Abell, AN; Jordan, NV; Huang, WC; Prat, A; Midland, AA; Johnson, NL; Granger, DA; Mieczkowski, PA; Perou, CM; Gomez, SM; Li, LP; Johnson, GL,期刊：Cell Stem Cell, 页码：525-537 , 文章类型： Article，,卷期：2011年8-5] Epithelial stem cells self-renew while maintaining multipotency, but the dependence of stem cell properties on maintenance of the epithelial phenotype is unclear. We previously showed that trophoblast stem (TS) cells lac... Human ESC-Derived Neural Crest Model Reveals a Key Role for SOX2 in Sensory Neurogenesis [作者：Cimadamore, F; Fishwick, K; Giusto, E; Gnedeva, K; Cattarossi, G; Miller, A; Pluchino, S; Brill, LM; Bronner-Fraser, M; Terskikh, AV,期刊：Cell Stem Cell, 页码：538-551 , 文章类型： Article，,卷期：2011年8-5] The transcription factor SOX2 is widely known to play a critical role in the central nervous system; however, its role in peripheral neurogenesis remains poorly understood. We recently developed an hESC-based model in wh... Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells [作者：Brownell, I; Guevara, E; Bai, CB; Loomis, CA; Joyner, AL,期刊：Cell Stem Cell, 页码：552-565 , 文章类型： Article，,卷期：2011年8-5] In adult skin, stem cells in the hair follicle bulge cyclically regenerate the follicle, whereas a distinct stem cell population maintains the epidermis. The degree to which all bulge cells have equal regenerative potent... Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus [作者：Encinas, JM; Michurina, TV; Peunova, N; Park, JH; Tordo, J; Peterson, DA; Fishell, G; Koulakov, A; Enikolopov, G,期刊：Cell Stem Cell, 页码：566-579 , 文章类型： Article，,卷期：2011年8-5] Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment. Here we show that continuous depletion of the neural stem cell pool, as a consequence of ...