- CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant
[作者：Sakamoto, H; Tsukaguchi, T; Hiroshima, S; Kodama, T; Kobayashi, T; Fukami, TA; Oikawa, N; Tsukuda, T; Ishii, N; Aoki, Y,期刊：Cancer Cell, 页码：679-690 , 文章类型： Article，,卷期：2011年19-5]
- Anaplastic lymphoma kinase (ALK) is a tyrosine kinase that is constitutively activated in certain cancers, following gene alterations such as chromosomal translocation, amplification, or point mutation. Here, we identifi...
- Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer
[作者：Carver, BS; Chapinski, C; Wongvipat, J; Hieronymus, H; Chen, Y; Chandarlapaty, S; Arora, VK; Le, C; Koutcher, J; Scher, H; Scardino, PT; Rosen, N; Sawyers, CL,期刊：Cancer Cell, 页码：575-586 , 文章类型： Article，,卷期：2011年19-5]
- Prostate cancer is characterized by its dependence on androgen receptor (AR) and frequent activation of PI3K signaling. We find that AR transcriptional output is decreased in human and murine tumors with PTEN deletion an...
- ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma
[作者：Loizou, JI; Sancho, R; Kanu, N; Bolland, DJ; Yang, FT; Rada, C; Corcoran, AE; Behrens, A,期刊：Cancer Cell, 页码：587-600 , 文章类型： Article，,卷期：2011年19-5]
- Defective V(D)J rearrangement of immunoglobulin heavy or light chain (IgH or IgL) or class switch recombination (CSR) can initiate chromosomal translocations. The DNA-damage kinase ATM is required for the suppression of ...
- High-Frequency Canonical Wnt Activation in Multiple Sarcoma Subtypes Drives Proliferation through a TCF/beta-Catenin Target Gene, CDC25A
[作者：Vijayakumar, S; Liu, GZ; Rus, IA; Yao, S; Chen, Y; Akiri, G; Grumolato, L; Aaronson, SA,期刊：Cancer Cell, 页码：601-612 , 文章类型： Article，,卷期：2011年19-5]
- Wnt canonical signaling is critical for normal development as well as homeostasis of several epithelial tissues, and constitutive activation of this pathway is commonly observed in carcinomas. We show here that 50% of hu...
- Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis
[作者：Bard-Chapeau, EA; Li, SW; Ding, J; Zhang, SS; Zhu, HH; Princen, F; Fang, DD; Han, T; Bailly-Maitre, B; Poli, V; Varki, NM; Wang, HY; Feng, GS,期刊：Cancer Cell, 页码：629-639 , 文章类型： Article，,卷期：2011年19-5]
- The human gene Ptpn11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in several types of leukemia. Herein we report a tumor-suppressor...
- Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Cancer Latency and Affect Tumor Type
[作者：Nguyen, DH; Oketch-Rabah, HA; Illa-Bochaca, I; Geyer, FC; Reis-Filho, JS; Mao, JH; Ravani, SA; Zavadi, J; Borowsky, AD; Jerry, DJ; Dunphy, KA; Seo, JH; Haslam, S; Medina, D; Barcellos-Hoff, MH,期刊：Cancer Cell, 页码：640-651 , 文章类型： Article，,卷期：2011年19-5]
- Tissue microenvironment is an important determinant of carcinogenesis. We demonstrate that ionizing radiation, a known carcinogen, affects cancer frequency and characteristics by acting on the microenvironment. Using a m...
- c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma
[作者：Blasco, RB; Francoz, S; Santamaria, D; Canamero, M; Dubus, P; Charron, J; Baccarini, M; Barbacid, M,期刊：Cancer Cell, 页码：652-663 , 文章类型： Article，,卷期：2011年19-5]
- We have investigated the role of individual members of the Raf/Mek/Erk cascade in the onset of K-Ras oncogene-driven non-small cell lung carcinoma (NSCLC). Ablation of Erk1 or Erk2 in K-Ras oncogene-expressing lung cells...
- Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer
[作者：Brenner, JC; Ateeq, B; Li, Y; Yocum, AK; Cao, Q; Asangani, IA; Patel, S; Wang, XJ; Liang, H; Yu, JD; Palanisamy, N; Siddiqui, J; Yan, W; Cao, XH; Mehra, R; Sabolch, A; Basrur, V; Lonigro, RJ; Yang, J; Tomlins, SA; Maher, CA; Elenitoba-Johnson, KSJ; Hussai,期刊：Cancer Cell, 页码：664-678 , 文章类型： Article，,卷期：2011年19-5]
- Recurrent fusions of ETS genes are considered driving mutations in a diverse array of cancers, including Ewing's sarcoma, acute myeloid leukemia, and prostate cancer. We investigate the mechanisms by which ETS fusions me...
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