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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   Oncogene-Induced Mitotic Stress: p53 and pRb Get Mad Too [作者：Malumbres, M,期刊：Cancer Cell, 页码：691-692 , 文章类型： Editorial Material，,卷期：2011年19-6] Oncogenic signaling frequently results in unscheduled overexpression of cell cycle proteins and replicative stress. In this issue of Cancer Cell, Schvartzman et al. show that inactivation of p53 or pRb induces Mad2, and ... A Lipid Kinase Cousin Cooperates to Promote Cancer [作者：Beagle, B; Fruman, DA,期刊：Cancer Cell, 页码：693-695 , 文章类型： Editorial Material，,卷期：2011年19-6] Phosphoinositide 3-kinases (PI3Ks) are considered promising drug targets in oncology. In this issue of Cancer Cell, Schmid et al. demonstrate that the PI3K gamma isoform is required for inflammatory myeloid cells to traf... ROCK-Driven Actomyosin Contractility Induces Tissue Stiffness and Tumor Growth [作者：Kumper, S; Marshall, CJ,期刊：Cancer Cell, 页码：695-697 , 文章类型： Editorial Material，,卷期：2011年19-6] The tumor environment consists of tumor-associated cells, such as macrophages, fibroblasts, and extracellular matrix, and has an important impact on tumor progression. In this issue of Cancer Cell, Samuel et al. show tha... Turning Reciprocal Feedback Regulation into Combination Therapy [作者：Thompson, TC,期刊：Cancer Cell, 页码：697-699 , 文章类型： Editorial Material，,卷期：2011年19-6] Two recent Cancer Cell articles report the discovery of reciprocal feedback regulation between androgenic and PTEN loss/PI3K-AKT signaling in prostate cancer. Both studies link endocrine regulation with a common oncogeni... Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition [作者：Schvartzman, JM; Duijf, PHG; Sotillo, R; Coker, C; Benezra, R,期刊：Cancer Cell, 页码：701-714 , 文章类型： Article，,卷期：2011年19-6] Multiple mechanisms have been proposed to explain how Rb and p53 tumor suppressor loss lead to chromosome instability (CIN). It was recently shown that Rb pathway inhibition causes overexpression of the mitotic checkpoin... Receptor Tyrosine Kinases and TLR/IL1 Rs Unexpectedly Activate Myeloid Cell PI3K gamma, A Single Convergent Point Promoting Tumor Inflammation and Progression [作者：Schmid, MC; Avraamides, CJ; Dippold, HC; Franco, I; Foubert, P; Ellies, LG; Acevedo, LM; Manglicmot, JRE; Song, XD; Wrasidlo, W; Blair, SL; Ginsberg, MH; Cheresh, DA; Hirsch, E; Field, SJ; Varner, JA,期刊：Cancer Cell, 页码：715-727 , 文章类型： Article，,卷期：2011年19-6] Tumor inflammation promotes angiogenesis, immunosuppression, and tumor growth, but the mechanisms controlling inflammatory cell recruitment to tumors are not well understood. We found that a range of chemoattractants act... Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence [作者：Guerra, C; Collado, M; Navas, C; Schuhmacher, AJ; Hernandez-Porras, I; Canamero, M; Rodriguez-Justo, M; Serrano, M; Barbacid, M,期刊：Cancer Cell, 页码：728-739 , 文章类型： Article，,卷期：2011年19-6] Pancreatic acinar cells of adult mice (>= P60) are resistant to transformation by some of the most robust oncogenic insults including expression of K-Ras oncogenes and loss of p16Ink4a/p19Arf or Trp53 tumor suppressors. ... Loss or Inhibition of Stromal-Derived PIGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1(+) Leukemia [作者：Schmidt, T; Masouleh, BK; Loges, S; Cauwenberghs, S; Fraisl, P; Maes, C; Jonckx, B; De Keersmaecker, K; Kleppe, M; Tjwa, M; Schenk, T; Vinckier, S; Fragoso, R; De Mol, M; Beel, K; Dias, S; Verfaillie, C; Clark, RE; Brummendorf, TH; Vandenberghe, P; Rafii,,期刊：Cancer Cell, 页码：740-753 , 文章类型： Article，,卷期：2011年19-6] Imatinib has revolutionized the treatment of BCR-ABL1(+) chronic myeloid leukemia (CML), but, in most patients, some leukemia cells persist despite continued therapy, while others become resistant. Here, we report that P... Cell of Origin of Small Cell Lung Cancer: Inactivation of Trp53 and Rb1 in Distinct Cell Types of Adult Mouse Lung [作者：Sutherland, KD; Proost, N; Brouns, I; Adriaensen, D; Song, JY; Berns, A,期刊：Cancer Cell, 页码：754-764 , 文章类型： Article，,卷期：2011年19-6] Small cell lung cancer (SCLC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we assessed the effect of Trp53 and Rb1 inactivation in distinct cell types in the adult l... Impairment of Cytoplasmic eIF6 Activity Restricts Lymphomagenesis and Tumor Progression without Affecting Normal Growth [作者：Miluzio, A; Beugnet, A; Grosso, S; Brina, D; Mancino, M; Campaner, S; Amati, B; de Marco, A; Biffo, S,期刊：Cancer Cell, 页码：765-775 , 文章类型： Article，,卷期：2011年19-6] Eukaryotic Initiation Factor 6 (eIF6) controls translation by regulating 80S subunit formation. eIF6 is overexpressed in tumors. Here, we demonstrate that eIF6 inactivation delays tumorigenesis and reduces tumor growth i... Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and beta-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth [作者：Samuel, MS; Lopez, JI; McGhee, EJ; Croft, DR; Strachan, D; Timpson, P; Munro, J; Schroder, E; Zhou, J; Brunton, VG; Barker, N; Clevers, H; Sansom, OJ; Anderson, KI; Weaver, VM; Olson, MF,期刊：Cancer Cell, 页码：776-791 , 文章类型： Article，,卷期：2011年19-6] Tumors and associated stroma manifest mechanical properties that promote cancer. Mechanosensation of tissue stiffness activates the Rho/ROCK pathway to increase actomyosin-mediated cellular tension to re-establish force ... Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth [作者：Mulholland, DJ; Tran, LM; Li, YF; Cai, HJ; Morim, A; Wang, SY; Plaisier, S; Garraway, IP; Huang, JT; Graeber, TG; Wu, H,期刊：Cancer Cell, 页码：792-804 , 文章类型： Article，,卷期：2011年19-6] Alteration of the PTEN/PI3K pathway is associated with late-stage and castrate-resistant prostate cancer (CRPC). However, how PTEN loss is involved in CRPC development is not clear. Here, we show that castration-resistan... PI3K gamma Mediates Kaposi's Sarcoma-Associated Herpesvirus vGPCR-Induced Sarcomagenesis [作者：Martin, D; Galisteo, R; Molinolo, AA; Wetzker, R; Hirsch, E; Gutkind, JS,期刊：Cancer Cell, 页码：805-813 , 文章类型： Article，,卷期：2011年19-6] Angioproliferative tumors induced by the Kaposi's sarcoma-associated herpesvirus (KSHV) have been successfully treated with rapamycin, which provided direct evidence of the clinical activity of mTOR inhibitors in human m... CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3 (vol 19, pg 541, 2011) [作者：Chen, JQ; Yao, YD; Gong, C; Yu, FY; Su, SC; Chen, JN; Liu, BD; Deng, H; Wang, FS; Lin, L; Yao, HR; Su, FX; Anderson, KS; Liu, Q; Ewen, ME; Yao, XB; Song, EW,期刊：Cancer Cell, 页码：814-816 , 文章类型： Correction，,卷期：2011年19-6]