- BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair
[作者:Ginjala, V; Nacerddine, K; Kulkarni, A; Oza, J; Hill, SJ; Yao, M; Citterio, E; van Lohuizen, M; Ganesan, S,期刊:Molecular and Cellular Biology, 页码:1972-1982 , 文章类型: Article,,卷期:2011年31-10]
- DNA damage activates signaling pathways that lead to modification of local chromatin and recruitment of DNA repair proteins. Multiple DNA repair proteins having ubiquitin ligase activity are recruited to sites of DNA dam...
- FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function
[作者:Mani, T; Hennigan, RF; Foster, LA; Conrady, DG; Herr, AB; Ip, W,期刊:Molecular and Cellular Biology, 页码:1983-1996 , 文章类型: Article,,卷期:2011年31-10]
- The neurofibromatosis type 2 tumor suppressor protein, merlin, is related to the ERM (ezrin, radixin, and moesin) family of plasma membrane-actin cytoskeleton linkers. For ezrin, phosphatidylinositol 4,5-bisphosphate (PI...
- Cooperative Role of the RNA-Binding Proteins Hzf and HuR in p53 Activation
[作者:Nakamura, H; Kawagishi, H; Watanabe, A; Sugimoto, K; Maruyama, M; Sugimoto, M,期刊:Molecular and Cellular Biology, 页码:1997-2009 , 文章类型: Article,,卷期:2011年31-10]
- The RNA-binding protein Hzf (hematopoietic zinc finger) plays important roles in mRNA translation in cerebellar Purkinje cells and adipocytes. We along with others have reported that the expression of the Hzf gene is tra...
- PEST Motif Serine and Tyrosine Phosphorylation Controls Vascular Endothelial Growth Factor Receptor 2 Stability and Downregulation
[作者:Meyer, RD; Srinivasan, S; Singh, AJ; Mahoney, JE; Gharahassanlou, KR; Rahimi, N,期刊:Molecular and Cellular Biology, 页码:2010-2025 , 文章类型: Article,,卷期:2011年31-10]
- The internalization and degradation of vascular endothelial growth factor receptor 2 (VEGFR-2), a potent angiogenic receptor tyrosine kinase, is a central mechanism for the regulation of the coordinated action of VEGF in...
- Essential and Redundant Functions of Caudal Family Proteins in Activating Adult Intestinal Genes
[作者:Verzi, MP; Shin, HJ; Ho, LL; Liu, XS; Shivdasani, RA,期刊:Molecular and Cellular Biology, 页码:2026-2039 , 文章类型: Article,,卷期:2011年31-10]
- Transcription factors that potently induce cell fate often remain expressed in the induced organ throughout life, but their requirements in adults are uncertain and varied. Mechanistically, it is unclear if they activate...
- Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells
[作者:Asano, T; Komatsu, M; Yamaguchi-Iwai, Y; Ishikawa, F; Mizushima, N; Iwai, K,期刊:Molecular and Cellular Biology, 页码:2040-2052 , 文章类型: Article,,卷期:2011年31-10]
- Ferritin is a cytosolic protein that stores excess iron, thereby protecting cells from iron toxicity. Ferritin-stored iron is believed to be utilized when cells become iron deficient; however, the mechanisms underlying t...
- The Ubiquitin-Specific Protease USP34 Regulates Axin Stability and Wnt/beta-Catenin Signaling
[作者:Lui, TTH; Lacroix, C; Ahmed, SM; Goldenberg, SJ; Leach, CA; Daulat, AM; Angers, S,期刊:Molecular and Cellular Biology, 页码:2053-2065 , 文章类型: Article,,卷期:2011年31-10]
- Wnt proteins control multiple cell behaviors during development and tissue homeostasis. However, pathological activation of Wnt signaling is the underlying cause of various human diseases. The ubiquitin-proteasome system...
- Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3(+) T-Regulatory Cells
[作者:de Zoeten, EF; Wang, LQ; Butler, K; Beier, UH; Akimova, T; Sai, H; Bradner, JE; Mazitschek, R; Kozikowski, AP; Matthias, P; Hancock, WW,期刊:Molecular and Cellular Biology, 页码:2066-2078 , 文章类型: Article,,卷期:2011年31-10]
- Foxp3(+) T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3(+) Tregs express multiple histone/protein deacetylase...
- Importin Beta Plays an Essential Role in the Regulation of the LysRS-Ap(4)A Pathway in Immunologically Activated Mast Cells
[作者:Carmi-Levy, I; Motzik, A; Ofir-Birin, Y; Yagil, Z; Yang, CM; Kemeny, DM; Han, JM; Kim, S; Kay, G; Nechushtan, H; Suzuki, R; Rivera, J; Razin, E,期刊:Molecular and Cellular Biology, 页码:2111-2121 , 文章类型: Article,,卷期:2011年31-10]
- We recently reported that diadenosine tetraphosphate hydrolase (Ap(4)A hydrolase) plays a critical role in gene expression via regulation of intracellular Ap(4)A levels. This enzyme serves as a component of our newly des...
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