- Phenotypes in mTERT(+/-) and mTERT(-/-) Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase
[作者:Strong, MA; Vidal-Cardenas, SL; Karim, B; Yu, HM; Guo, N; Greider, CW,期刊:Molecular and Cellular Biology, 页码:2369-2379 , 文章类型: Article,,卷期:2011年31-12]
- Telomerase is essential for telomere length maintenance. Mutations in either of the two core components of telomerase, telomerase RNA (TR) or the catalytic protein component telomerase reverse transcriptase (TERT), cause...
- Mrc1 Marks Early-Firing Origins and Coordinates Timing and Efficiency of Initiation in Fission Yeast
[作者:Hayano, M; Kanoh, Y; Matsumoto, S; Masai, H,期刊:Molecular and Cellular Biology, 页码:2380-2391 , 文章类型: Article,,卷期:2011年31-12]
- How early-and late-firing origins are selected on eukaryotic chromosomes is largely unknown. Here, we show that Mrc1, a conserved factor required for stabilization of stalled replication forks, selectively binds to the e...
- Hepatocyte-Derived Snail1 Propagates Liver Fibrosis Progression
[作者:Rowe, RG; Lin, YS; Shimizu-Hirota, R; Hanada, S; Neilson, EG; Greenson, JK; Weiss, SJ,期刊:Molecular and Cellular Biology, 页码:2392-2403 , 文章类型: Article,,卷期:2011年31-12]
- Chronic exposure of the liver to hepatotoxic agents initiates an aberrant wound healing response marked by proinflammatory, as well as fibrotic, changes, leading to compromised organ structure and function. In a variety ...
- A Weak C ' Box Renders U3 snoRNA Levels Dependent on hU3-55K Binding
[作者:Knox, AA; McKeegan, KS; Debieux, CM; Traynor, A; Richardson, H; Watkins, NJ,期刊:Molecular and Cellular Biology, 页码:2404-2412 , 文章类型: Article,,卷期:2011年31-12]
- The rate of ribosome biogenesis, which is downregulated in terminally differentiated cells and upregulated in most cancers, regulates the growth rate and is linked to the cell's proliferative potential. The U3 box C/D sm...
- Mediator Influences Telomeric Silencing and Cellular Life Span
[作者:Zhu, XF; Liu, BD; Carlsten, JOP; Beve, J; Nystrom, T; Myers, LC; Gustafsson, CM,期刊:Molecular and Cellular Biology, 页码:2413-2421 , 文章类型: Article,,卷期:2011年31-12]
- The Mediator complex is required for the regulated transcription of nearly all RNA polymerase II-dependent genes. Here we demonstrate a new role for Mediator which appears to be separate from its function as a transcript...
- Kinase Suppressor of Ras 1 (KSR1) Regulates PGC1 alpha and Estrogen-Related Receptor alpha To Promote Oncogenic Ras-Dependent Anchorage-Independent Growth
[作者:Fisher, KW; Das, B; Kortum, RL; Chaika, OV; Lewis, RE,期刊:Molecular and Cellular Biology, 页码:2453-2461 , 文章类型: Article,,卷期:2011年31-12]
- Kinase suppressor of ras 1 (KSR1) is a molecular scaffold of the Raf/MEK/extracellular signal-regulated kinase (ERK) cascade that enhances oncogenic Ras signaling. Here we show KSR1-dependent, but ERK-independent, regula...
- The USP1/UAF1 Complex Promotes Double-Strand Break Repair through Homologous Recombination
[作者:Murai, J; Yang, KL; Dejsuphong, D; Hirota, K; Takeda, S; D'Andrea, AD,期刊:Molecular and Cellular Biology, 页码:2462-2469 , 文章类型: Article,,卷期:2011年31-12]
- Protein ubiquitination plays a key role in the regulation of a variety of DNA repair mechanisms. Protein ubiquitination is controlled by the coordinate activity of ubiquitin ligases and deubiquitinating enzymes (DUBs). T...
- S-Phase Cyclin-Dependent Kinases Promote Sister Chromatid Cohesion in Budding Yeast
[作者:Hsu, WS; Erickson, SL; Tsai, HJ; Andrews, CA; Vas, AC; Clarke, DJ,期刊:Molecular and Cellular Biology, 页码:2470-2483 , 文章类型: Article,,卷期:2011年31-12]
- Genome stability depends on faithful chromosome segregation, which relies on maintenance of chromatid cohesion during S phase. In eukaryotes, Pds1/securin is the only known inhibitor that can prevent loss of cohesion. Ho...
- mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells
[作者:Goncharova, EA; Goncharov, DA; Li, H; Pimtong, W; Lu, S; Khavin, I; Krymskaya, VP,期刊:Molecular and Cellular Biology, 页码:2484-2498 , 文章类型: Article,,卷期:2011年31-12]
- Mutational inactivation of the tumor suppressor tuberous sclerosis complex 2 (TSC2) constitutively activates mTORC1, increases cell proliferation, and induces the pathological manifestations observed in tuberous sclerosi...
- Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila
[作者:Nakajima, Y; Kuranaga, E; Sugimura, K; Miyawaki, A; Miura, M,期刊:Molecular and Cellular Biology, 页码:2499-2512 , 文章类型: Article,,卷期:2011年31-12]
- Tissue remodeling involves collective cell movement, and cell proliferation and apoptosis are observed in both development and disease. Apoptosis and proliferation are considered to be closely correlated, but little is k...
- A KLF4-miRNA-206 Autoregulatory Feedback Loop Can Promote or Inhibit Protein Translation Depending upon Cell Context
[作者:Lin, CC; Liu, LZ; Addison, JB; Wonderlin, WF; Ivanov, AV; Ruppert, JM,期刊:Molecular and Cellular Biology, 页码:2513-2527 , 文章类型: Article,,卷期:2011年31-12]
- Kruppel-like factor 4 (KLF4), a transcription factor that regulates cell fate in a context-dependent fashion, is normally induced upon growth arrest or differentiation. In many cancer cells there is dysregulation, with i...
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