- Structural Basis and Specificity of Acetylated Transcription Factor GATA1 Recognition by BET Family Bromodomain Protein Brd3
[作者:Gamsjaeger, R; Webb, SR; Lamonica, JM; Billin, A; Blobel, GA; Mackay, JP,期刊:Molecular and Cellular Biology, 页码:2632-2640 , 文章类型: Article,,卷期:2011年31-13]
- Recent data demonstrate that small synthetic compounds specifically targeting bromodomain proteins can modulate the expression of cancer-related or inflammatory genes. Although these studies have focused on the ability o...
- The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3
[作者:Rahman, S; Sowa, ME; Ottinger, M; Smith, JA; Shi, Y; Harper, JW; Howley, PM,期刊:Molecular and Cellular Biology, 页码:2641-2652 , 文章类型: Article,,卷期:2011年31-13]
- Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression, and virus-host pathogenesis. To gain mechanistic insight into the various biological functions of Brd4, we performed a proteomic analy...
- Functional Cooperation between the Proteins Nck and ADAP Is Fundamental for Actin Reorganization
[作者:Pauker, MH; Reicher, B; Fried, S; Perl, O; Barda-Saad, M,期刊:Molecular and Cellular Biology, 页码:2653-2666 , 文章类型: Article,,卷期:2011年31-13]
- T cell antigen receptor (TCR) activation triggers profound changes in the actin cytoskeleton. In addition to controlling cellular shape and polarity, this process regulates vital T cell responses, such as T cell adhesion...
- Semiquantitative Proteomic Analysis of the Human Spliceosome via a Novel Two-Dimensional Gel Electrophoresis Method
[作者:Agafonov, DE; Deckert, J; Wolf, E; Odenwalder, P; Bessonov, S; Will, CL; Urlaub, H; Luhrmann, R,期刊:Molecular and Cellular Biology, 页码:2667-2682 , 文章类型: Article,,卷期:2011年31-13]
- More than 200 proteins associate with human spliceosomes, but little is known about their relative abundances in a given spliceosomal complex. Here we describe a novel two-dimensional (2D) electrophoresis method that all...
- The Ras Signaling Inhibitor LOX-PP Interacts with Hsp70 and c-Raf To Reduce Erk Activation and Transformed Phenotype of Breast Cancer Cells
[作者:Sato, S; Trackman, PC; Maki, JM; Myllyharju, J; Kirsch, KH; Sonenshein, GE,期刊:Molecular and Cellular Biology, 页码:2683-2695 , 文章类型: Article,,卷期:2011年31-13]
- The lysyl oxidase gene (LOX) inhibits Ras signaling in transformed fibroblasts and breast cancer cells. Its activity was mapped to the 162-amino-acid propeptide domain (LOX-PP) of the lysyl oxidase precursor protein. LOX...
- The TFIIF-Like Rpc37/53 Dimer Lies at the Center of a Protein Network To Connect TFIIIC, Bdp1, and the RNA Polymerase III Active Center
[作者:Wu, CC; Lin, YC; Chen, HT,期刊:Molecular and Cellular Biology, 页码:2715-2728 , 文章类型: Article,,卷期:2011年31-13]
- Eukaryotic RNA polymerase III (Pol III) relies on a transcription factor TFIIF-like Rpc37/53 subcomplex for promoter opening, elongation, termination, and reinitiation. By incorporating the photoreactive amino acid p-ben...
- A Barrier-Only Boundary Element Delimits the Formation of Facultative Heterochromatin in Drosophila melanogaster and Vertebrates
[作者:Lin, NW; Li, XG; Cui, KR; Chepelev, I; Tie, F; Liu, B; Li, GY; Harte, P; Zhao, KJ; Huang, SM; Zhou, L,期刊:Molecular and Cellular Biology, 页码:2729-2741 , 文章类型: Article,,卷期:2011年31-13]
- Formation of facultative heterochromatin at specific genomic loci is fundamentally important in defining cellular properties such as differentiation potential and responsiveness to developmental, physiological, and envir...
- Distinct Properties of Human HMGN5 Reveal a Rapidly Evolving but Functionally Conserved Nucleosome Binding Protein
[作者:Malicet, C; Rochman, M; Postnikov, Y; Bustin, M,期刊:Molecular and Cellular Biology, 页码:2742-2755 , 文章类型: Article,,卷期:2011年31-13]
- The HMGN family is a family of nucleosome-binding architectural proteins that affect the structure and function of chromatin in vertebrates. We report that the HMGN5 variant, encoded by a gene located on chromosome X, is...
- Mechanistic Analysis of a DNA Damage-Induced, PTEN-Dependent Size Checkpoint in Human Cells
[作者:Kim, JS; Xu, XH; Li, HF; Solomon, D; Lane, WS; Jin, T; Waldman, T,期刊:Molecular and Cellular Biology, 页码:2756-2771 , 文章类型: Article,,卷期:2011年31-13]
- Following DNA damage, human cells undergo arrests in the G(1) and G(2) phases of the cell cycle and a simultaneous arrest in cell size. We previously demonstrated that the cell size arrest can be uncoupled from the cell ...
- Forced Expression of Cyclin-Dependent Kinase 6 Confers Resistance of Pro-B Acute Lymphocytic Leukemia to Gleevec Treatment
[作者:Kuo, TC; Chavarria-Smith, JE; Huang, D; Schlissel, MS,期刊:Molecular and Cellular Biology, 页码:2566-2576 , 文章类型: Article,,卷期:2011年31-13]
- The gene encoding c-ABL, a nonreceptor protein tyrosine kinase, is involved in a chromosomal translocation resulting in expression of a BCR-Abl fusion protein that causes most chronic myelogenous and some acute lymphocyt...
- Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation
[作者:Liang, J; Fu, Y; Cruciat, CM; Jia, SJ; Wang, Y; Tong, Z; Tao, QH; Ingelfinger, D; Boutros, M; Meng, AM; Niehrs, C; Wu, W,期刊:Molecular and Cellular Biology, 页码:2577-2590 , 文章类型: Article,,卷期:2011年31-13]
- Wnt/beta-catenin signaling is fundamental in embryogenesis and tissue homeostasis in metazoans. Upon Wnt stimulation, cognate coreceptors LRP5 and LRP6 ([LRP5/6] low-density lipoprotein receptor-related proteins 5 and 6)...
- Characterization of Basigin Isoforms and the Inhibitory Function of Basigin-3 in Human Hepatocellular Carcinoma Proliferation and Invasion
[作者:Liao, CG; Kong, LM; Song, F; Xing, JL; Wang, LX; Sun, ZJ; Tang, H; Yao, H; Zhang, Y; Wang, L; Wang, Y; Yang, XM; Li, Y; Chen, ZN,期刊:Molecular and Cellular Biology, 页码:2591-2604 , 文章类型: Article,,卷期:2011年31-13]
- Basigin, which has four isoforms, plays an important role in invasion of hepatocellular carcinoma (HCC). Detailed transcriptional regulation and functions of the basigin isoforms have not been reported except in the case...
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