- PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice
[作者：Qiu, W; Wu, B; Wang, XW; Buchanan, ME; Regueiro, MD; Hartman, DJ; Schoen, RE; Yu, J; Zhang, L,期刊：Journal of clinical investigation, 页码：1722-1732 , 文章类型： Article，,卷期：2011年121-5]
- Intestinal epithelial cell (IEC) apoptosis contributes to the development of ulcerative colitis (UC), an inflammatory bowel disease (IBD) that affects the colon and rectum. Therapies that target the inflammatory cytokine...
- CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice
[作者：Hang, TTN; Dalmasso, G; Torkvist, L; Halfvarson, J; Yan, YT; Laroui, H; Shmerling, D; Tallone, T; D'Amato, M; Sitaraman, SV; Merlin, D,期刊：Journal of clinical investigation, 页码：1733-1747 , 文章类型： Article，,卷期：2011年121-5]
- Expression of the transmembrane glycoprotein CD98 (encoded by SLC3A2) is increased in intestinal inflammatory conditions, such as inflammatory bowel disease (IBD), and in various carcinomas, yet its pathogenetic role rem...
- Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer
[作者：Steine, EJ; Ehrich, M; Bell, GW; Raj, A; Reddy, S; van Oudenaarden, A; Jaenisch, R; Linhart, HG,期刊：Journal of clinical investigation, 页码：1748-1752 , 文章类型： Article，,卷期：2011年121-5]
- Human cancer cells frequently have regions of their DNA hypermethylated, which results in transcriptional silencing of affected genes and promotion of tumor formation. However, it is still unknown whether cancerassociate...
- Loss of TFF1 is associated with activation of NF-kappa B-mediated inflammation and gastric neoplasia in mice and humans
[作者：Soutto, M; Belkhiri, A; Piazuelo, MB; Schneider, BG; Peng, DF; Jiang, AX; Washington, MK; Kokoye, Y; Crowe, SE; Zaika, A; Correa, P; Peek, RM; El-Rifai, W,期刊：Journal of clinical investigation, 页码：1753-1767 , 文章类型： Article，,卷期：2011年121-5]
- Trefoil factor 1 (TFF1) is a tumor suppressor gene that encodes a peptide belonging to the trefoil factor family of protease-resistant peptides. Although TFF1 expression is frequently lost in gastric carcinomas, the tumo...
- Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations
[作者：Grachtchouk, M; Pero, J; Yang, SH; Ermilov, AN; Michael, LE; Wang, AQ; Wilbert, D; Patel, RM; Ferris, J; Diener, J; Allen, M; Lim, S; Syu, LJ; Verhaegen, M; Dlugosz, AA,期刊：Journal of clinical investigation, 页码：1768-1781 , 文章类型： Article，,卷期：2011年121-5]
- Uncontrolled Hedgehog (Hh) signaling leads to the development of basal cell carcinoma (BCC), the most common human cancer, but the cell of origin for BCC is unclear. While Hh pathway dysregulation is common to essentiall...
- Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets
[作者：Kastenmuller, K; Wille-Reece, U; Lindsay, RWB; Trager, LR; Darrah, PA; Flynn, BJ; Becker, MR; Udey, MC; Clausen, BE; Igyarto, BZ; Kaplan, DH; Kastenmuller, W; Germain, RN; Seder, RA,期刊：Journal of clinical investigation, 页码：1782-1796 , 文章类型： Article，,卷期：2011年121-5]
- The success of a non-live vaccine requires improved formulation and adjuvant selection to generate robust T cell immunity following immunization. Here, using protein linked to a TLR7/8 agonist (conjugate vaccine), we inv...
- Cytomegalovirus: pathogen, paradigm, and puzzle
[作者：Boeckh, M; Geballe, AP,期刊：Journal of clinical investigation, 页码：1673-1680 , 文章类型： Article，,卷期：2011年121-5]
- Human cytomegalovirus (CMV), one of the eight herpesviruses that commonly infect humans, is best known for its propensity to cause disease in immunocompromised patients, especially transplant recipients, patients with ad...
- Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80(+)CD11b(high)Gr1(low) macrophages
[作者：Schiechl, G; Bauer, B; Fuss, I; Lang, SA; Moser, C; Ruemmele, P; Rose-John, S; Neurath, MF; Geissler, EK; Schlitt, HJ; Strober, W; Fichtner-Feigl, S,期刊：Journal of clinical investigation, 页码：1692-1708 , 文章类型： Article，,卷期：2011年121-5]
- Patients with prolonged ulcerative colitis (UC) frequently develop colorectal adenocarcinoma for reasons that are not fully clear. To analyze inflammation-associated colonic tumorigenesis, we developed a chronic form of ...
- Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice
[作者：Lerner, I; Hermano, E; Zcharia, E; Rodkin, D; Bulvik, R; Doviner, V; Rubinstein, AM; Ishai-Michaeli, R; Atzmon, R; Sherman, Y; Meirovitz, A; Peretz, T; Vlodavsky, I; Elkin, M,期刊：Journal of clinical investigation, 页码：1709-1721 , 文章类型： Article，,卷期：2011年121-5]
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated with colon cancer. Expression of the enzyme heparanase is clearly linked to colon carcinoma progression, but its role in UC is un...
- Autoimmune melanocyte destruction is required for robust CD8(+) memory T cell responses to mouse melanoma
[作者：Byrne, KT; Cote, AL; Zhang, PS; Steinberg, SM; Guo, YX; Allie, R; Zhang, WJ; Ernstoff, MS; Usherwood, EJ; Turk, MJ,期刊：Journal of clinical investigation, 页码：1797-1809 , 文章类型： Article，,卷期：2011年121-5]
- A link between autoimmunity and improved antitumor immunity has long been recognized, although the exact mechanistic relationship between these two phenomena remains unclear. In the present study we have found that vitil...
- Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice
[作者：Viret, C; Leung-Theung-Long, S; Serre, L; Lamare, C; Vignali, DAA; Malissen, B; Carrier, A; Guerder, S,期刊：Journal of clinical investigation, 页码：1810-1821 , 文章类型： Article，,卷期：2011年121-5]
- Type 1 diabetes is a chronic autoimmune disease in which genetic predispositions affect the immune system, leading to a loss of T cell tolerance to 13 cells and consequent T cell-mediated destruction of insulin-producing...
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