- Status of research on matrix metalloproteinases (MMPs) in India
[作者:Bulbule, A; Saraswati, S; Kundu, GC,期刊:Expert Opinion on Therapeutic Targets, 页码:671-675 , 文章类型: Editorial Material,,卷期:2011年15-6]
- Introduction: MMPs are extracellular matrix (ECM)-degrading enzymes that play a crucial role in embryogenesis, tissue remodeling, inflammation and angiogenesis. MMP-2 and -9 (also called type 2 and type 4 collagenase, or...
- Targeting p27(Kip1) protein: its relevance in the therapy of human cancer
[作者:Borriello, A; Bencivenga, D; Criscuolo, M; Caldarelli, I; Cucciolla, V; Tramontano, A; Borgia, A; Spina, A; Oliva, A; Naviglio, S; Della Ragione, F,期刊:Expert Opinion on Therapeutic Targets, 页码:677-693 , 文章类型: Review,,卷期:2011年15-6]
- Introduction: Cell division cycle progression is achieved by a sequential and stringently concerted activation of a family of serine-threonine kinases, namely the cyclin-dependent kinases (CDKs). p27(Kip1) is a pivotal C...
- Targeting interleukin-21 in inflammatory diseases
[作者:Sarra, M; Franze, E; Pallone, F; Monteleone, G,期刊:Expert Opinion on Therapeutic Targets, 页码:695-702 , 文章类型: Review,,卷期:2011年15-6]
- Introduction: IL-21, a new member of the type 1 cytokine superfamily, is produced by various subsets of CD4(+) T cells and binds to a composite receptor that consists of a specific receptor, termed IL-21 receptor and the...
- Toll-like receptors as potential therapeutic targets in cardiac dysfunction
[作者:Hofmann, U; Ertl, G; Frantz, S,期刊:Expert Opinion on Therapeutic Targets, 页码:753-765 , 文章类型: Review,,卷期:2011年15-6]
- Introduction: The innate immune system can detect the highly conserved, relatively invariant structural motifs of pathogens. The most important innate immune receptors, Toll-like receptors (TLRs), represent a first line ...
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