- Disruptive Events in the Life of Prostate Cancer
[作者：Brenner, JC; Chinnaiyan, AM,期刊：Cancer Cell, 页码：301-303 , 文章类型： Editorial Material，,卷期：2011年19-3]
- Two recent reports in Nature provide evidence for increasingly complex "disruptive" molecular alterations that occur during prostate cancer progression. They shed light on the intricacy of genetic changes that modulate P...
- Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain
[作者：Chow, LML; Endersby, R; Zhu, XY; Rankin, S; Qu, CX; Zhang, JY; Broniscer, A; Ellison, DW; Baker, SJ,期刊：Cancer Cell, 页码：305-316 , 文章类型： Article，,卷期：2011年19-3]
- Mutations in the PTEN, TP53, and RB1 pathways are obligate events in the pathogenesis of human glioblastomas. We induced various combinations of deletions in these tumor suppressors in astrocytes and neural precursors in...
- URI Is an Oncogene Amplified in Ovarian Cancer Cells and Is Required for Their Survival
[作者：Theurillat, JP; Metzler, SC; Henzi, N; Djouder, N; Helbling, M; Zimmermann, AK; Jacob, F; Soltermann, A; Caduff, R; Heinzelmann-Schwarz, V; Moch, H; Krek, W,期刊：Cancer Cell, 页码：317-332 , 文章类型： Article，,卷期：2011年19-3]
- Abrogation of negative feedback control represents a fundamental requirement for aberrantly activated signaling pathways to promote malignant transformation and resistance to therapy. Here we identify URI, which encodes ...
- Matrix Metalloproteinse-2 Conditions Human Dendritic Cells to Prime Inflammatory T(H)2 Cells via an IL-12-and OX40L-Dependent Pathway
[作者：Godefroy, E; Manches, O; Dreno, B; Hochman, T; Rolnitzky, L; Labarriere, N; Guilloux, Y; Goldberg, J; Jotereau, F; Bhardwaj, N,期刊：Cancer Cell, 页码：333-346 , 文章类型： Article，,卷期：2011年19-3]
- Matrix metalloproteinase-2 (MMP-2) is a proteolytic enzyme degrading the extracellular matrix and overexpressed by many tumors. Here, we documented the presence of MMP-2-specific CD4(+) T cells in tumor-infiltrating lymp...
- Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening
[作者：Sawey, ET; Chanrion, M; Cai, CL; Wu, GM; Zhang, JP; Zender, L; Zhao, A; Busutti, RW; Yee, H; Stein, L; French, DM; Finn, RS; Lowe, SW; Powers, S,期刊：Cancer Cell, 页码：347-358 , 文章类型： Article，,卷期：2011年19-3]
- We screened 124 genes that are amplified in human hepatocellular carcinoma (HCC) using a mouse hepatoblast model and identified 18 tumor-promoting genes, including CCND1 and its neighbor on 11q13.3, FGF19. Although it is...
- The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma
[作者：Mehta, S; Huillard, E; Kesari, S; Maire, CL; Golebiowski, D; Harrington, EP; Alberta, JA; Kane, MF; Theisen, M; Ligon, KL; Rowitch, DH; Stiles, CD,期刊：Cancer Cell, 页码：359-371 , 文章类型： Article，,卷期：2011年19-3]
- High-grade gliomas are notoriously insensitive to radiation and genotoxic drugs. Paradoxically, the p53 gene is structurally intact in the majority of these tumors. Resistance to genotoxic modalities in p53-positive glio...
- Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis
[作者：Eckert, MA; Lwin, TM; Chang, AT; Kim, J; Danis, E; Ohno-Machado, L; Yang, J,期刊：Cancer Cell, 页码：372-386 , 文章类型： Article，,卷期：2011年19-3]
- The Twist1 transcription factor is known to promote tumor metastasis and induce Epithelial-Mesenchymal Transition (EMT). Here, we report that Twist1 is capable of promoting the formation of invadopodia, specialized membr...
- CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc(-) and Thereby Promotes Tumor Growth
[作者：Ishimoto, T; Nagano, O; Yae, T; Tamada, M; Motohara, T; Oshima, H; Oshima, M; Ikeda, T; Asaba, R; Yagi, H; Masuko, T; Shimizu, T; Ishikawa, T; Kai, K; Takahashi, E; Imamura, Y; Baba, Y; Ohmura, M; Suematsu, M; Baba, H; Saya, H,期刊：Cancer Cell, 页码：387-400 , 文章类型： Article，,卷期：2011年19-3]
- CD44 is an adhesion molecule expressed in cancer stem-like cells. Here, we show that a CD44 variant (CD44v) interacts with xCT, a glutamate-cystine transporter, and controls the intracellular level of reduced glutathione...
- Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O-2(-):H2O2 Ratio and Confers Anoikis Resistance to Tumors
[作者：Zhu, PC; Tan, MJ; Huang, RL; Tan, CK; Chong, HC; Pal, M; Lam, CRI; Boukamp, P; Pan, JY; Tan, SH; Kersten, S; Li, HY; Ding, JL; Tan, NS,期刊：Cancer Cell, 页码：401-415 , 文章类型： Article，,卷期：2011年19-3]
- Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGPTL4) in cancer remains u...
- SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1 alpha Destabilization
[作者：Finley, LWS; Carracedo, A; Lee, J; Souza, A; Egia, A; Zhang, JW; Teruya-Feldstein, J; Moreira, PI; Cardoso, SM; Clish, CB; Pandolfi, PP; Haigis, MC,期刊：Cancer Cell, 页码：416-428 , 文章类型： Article，,卷期：2011年19-3]
- Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates required for bi...
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