Cancer gene therapy————————个性化文献订阅—

TRAIL-transduced multipotent mesenchymal stromal cells (TRAIL-MSC) overcome TRAIL resistance in selected CRC cell lines in vitro and in vivo
[作者：Mueller, LP; Luetzkendorf, J; Widder, M; Nerger, K; Caysa, H; Mueller, T,期刊：Cancer gene therapy, 页码：229-239 , 文章类型： Article，,卷期：2011年18-4]
Tumor-integrating multipotent mesenchymal stromal cells (MSC) expressing transgenes with anti-tumor activity may serve as vehicles for tumor therapy. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) repres...

Novel adenovirus-based helper system to support production of recombinant parvovirus
[作者：El-Andaloussi, N; Endele, M; Leuchs, B; Bonifati, S; Kleinschmidt, J; Rommelaere, J; Marchini, A,期刊：Cancer gene therapy, 页码：240-249 , 文章类型： Article，,卷期：2011年18-4]
Preclinical studies using various cell culture and animal systems highlight the potential of recombinant rodent parvoviruses (recPVs) for cancer therapy. Production of these viruses is, however, not efficient and this ha...

Transfection of NF-kappa B decoy oligodeoxynucleotide suppresses pulmonary metastasis by murine osteosarcoma
[作者：Nishimura, A; Akeda, K; Matsubara, T; Kusuzaki, K; Matsumine, A; Masuda, K; Gemba, T; Uchida, A; Sudo, A,期刊：Cancer gene therapy, 页码：250-259 , 文章类型： Article，,卷期：2011年18-4]
Nuclear factor-kappa B (NF-kappa B) has a pivotal role in the progression and distant metastasis of cancers, including malignant bone tumors. To inhibit NF-kappa B activation, a new molecular therapy using synthetic doub...

Direct gene transfer of adenoviral-mediated interferon alpha into human bladder cancer cells but not the bystander factors produced induces endoplasmic reticulum stress-related cytotoxicity
[作者：Zhang, XQ; Yang, Z; Benedict, WF,期刊：Cancer gene therapy, 页码：260-264 , 文章类型： Article，,卷期：2011年18-4]
We have previously shown that adenoviral-mediated interferon alpha (Ad-IFN alpha) is cytotoxic both to cells that are sensitive to recombinant interferon alpha (IFN alpha) and to cells which are resistant to IFN alpha. T...

Pre-clinical toxicity assessment of tumor-targeted interleukin-12 low-intensity electrogenetherapy
[作者：Reed, SD; Li, S,期刊：Cancer gene therapy, 页码：265-274 , 文章类型： Article，,卷期：2011年18-4]
This study's goal was to assess the safety of tumor-targeted interleukin-12 (ttIL-12) when administered by electrogenetherapy in C3H/HeJ mice by identifying an initial safe dose for human dose escalation schemes, toxi...

Retargeting adenoviral vectors to improve gene transfer into tumors
[作者：Hogg, RT; Thorpe, P; Gerard, RD,期刊：Cancer gene therapy, 页码：275-287 , 文章类型： Article，,卷期：2011年18-4]
Gene targeting to tumors using adenoviral (Ad) vectors holds great potential for cancer imaging and therapy, but the limited efficacy of current methods used to improve delivery to target tissues and reduce unwanted inte...

Oncolytic adenovirus based on serotype 3
[作者：Hemminki, O; Bauerschmitz, G; Hemmi, S; Lavilla-Alonso, S; Diaconu, I; Guse, K; Koski, A; Desmond, RA; Lappalainen, M; Kanerva, A; Cerullo, V; Pesonen, S; Hemminki, A,期刊：Cancer gene therapy, 页码：288-296 , 文章类型： Article，,卷期：2011年18-4]
Oncolytic adenoviruses have been safe in clinical trials but the efficacy has been mostly limited. All published trials have been performed with serotype 5 based viruses. The expression level of the Ad5 receptor CAR may ...

Effects of RNA interference targeting four different genes on the growth and proliferation of nasopharyngeal carcinoma CNE-2Z cells
[作者：Song, Y; Dong, MM; Yang, HF,期刊：Cancer gene therapy, 页码：297-304 , 文章类型： Article，,卷期：2011年18-4]
To explore the effects of RNA interference targeting four different genes (VEGF, C-myc, Survivin, hTERT) on the growth and proliferation of nasopharyngeal carcinoma (NPC) CNE-2Z cells. Fluorescein-labeled short-hairpi...