- Insulin Signaling: Inositol Phosphates Get into the Akt
[作者：Manning, BD,期刊：Cell, 页码：861-863 , 文章类型： Editorial Material，,卷期：2010年143-6]
- An acute but transient response to insulin is essential for glucose homeostasis in mammals. Chakraborty et al. (2010) uncover a new feedback mechanism regulating insulin signaling. They show that the inositol pyrophospha...
- Consequences of mRNA Wardrobe Malfunctions
[作者：Wilusz, CJ; Wilusz, J,期刊：Cell, 页码：863-865 , 文章类型： Editorial Material，,卷期：2010年143-6]
- As mRNAs are generated, they are clothed with proteins to form messenger ribonucleoprotein particles (mRNPs), which are then actively remodeled during various steps of gene expression. Franks et al. (2010) now show that ...
- Kinases Charging to the Membrane
[作者：Hadders, MA; Williams, RL,期刊：Cell, 页码：865-867 , 文章类型： Editorial Material，,卷期：2010年143-6]
- Being at the right place and time is as fundamental to biology as it is to academic careers. In this issue, Moravcevic and colleagues (2010) survey membrane-interacting proteins in yeast and discover a new membrane-targe...
- Exposing Contingency Plans for Kinase Networks
[作者：Klein, AM; Dioum, EM; Cobb, MH,期刊：Cell, 页码：867-869 , 文章类型： Editorial Material，,卷期：2010年143-6]
- Understanding how signaling pathways are interconnected is vital for characterizing mechanisms of normal development and disease pathogenesis. In this issue, Van Wageningen et al. (2010) examine phosphorylation networks ...
- Lipid Trafficking sans Vesicles: Where, Why, How
[作者：Prinz, WA,期刊：Cell, 页码：870-874 , 文章类型： Article，,卷期：2010年143-6]
- Eukaryotic cells possess a remarkable diversity of lipids, which distribute among cellular membranes by well-characterized vesicle trafficking pathways. However, transport of lipids by alternate, or "nonvesicular," route...
- Lipidomics: New Tools and Applications
[作者：Wenk, MR,期刊：Cell, 页码：888-895 , 文章类型： Article，,卷期：2010年143-6]
- Once viewed simply as a reservoir for carbon storage, lipids are no longer cast as bystanders in the drama of biological systems. The emerging field of lipidomics is driven by technology, most notably mass spectrometry, ...
- Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain
[作者：Chakraborty, A; Koldobskiy, MA; Bello, NT; Maxwell, M; Potter, JJ; Juluri, KR; Maag, D; Kim, S; Huang, AS; Dailey, MJ; Saleh, M; Snowman, AM; Moran, TH; Mezey, E; Snyder, SH,期刊：Cell, 页码：897-910 , 文章类型： Article，,卷期：2010年143-6]
- The inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate), formed by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates diverse cellular activities. We now report that IP7 is a physiologic...
- Loss of Anion Transport without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia
[作者：Chen, JH; Stoltz, DA; Karp, PH; Ernst, SE; Pezzulo, AA; Moninger, TO; Rector, MV; Reznikov, LR; Launspach, JL; Chaloner, K; Zabner, J; Welsh, MJ,期刊：Cell, 页码：911-923 , 文章类型： Article，,卷期：2010年143-6]
- Defective transepithelial electrolyte transport is thought to initiate cystic fibrosis (CF) lung disease. Yet, how loss of CFTR affects electrolyte transport remains uncertain. CFTR-/- pigs spontaneously develop lung dis...
- Sister Cohesion and Structural Axis Components Mediate Homolog Bias of Meiotic Recombination
[作者：Kim, KP; Weiner, BM; Zhang, LR; Jordan, A; Dekker, J; Kleckner, N,期刊：Cell, 页码：924-937 , 文章类型： Article，,卷期：2010年143-6]
- Meiotic double-strand break (DSB)-initiated recombination must occur between homologous maternal and paternal chromosomes ("homolog bias"), even though sister chromatids are present. Through physical recombination analys...
- Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics
[作者：Bennett, EJ; Rush, J; Gygi, SP; Harper, JW,期刊：Cell, 页码：951-965 , 文章类型： Article，,卷期：2010年143-6]
- Dynamic reorganization of signaling systems frequently accompanies pathway perturbations, yet quantitative studies of network remodeling by pathway stimuli are lacking. Here, we report the development of a quantitative p...
- Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids
[作者：Moravcevic, K; Mendrola, JM; Schmitz, KR; Wang, YH; Slochower, D; Janmey, PA; Lemmon, MA,期刊：Cell, 页码：966-977 , 文章类型： Article，,卷期：2010年143-6]
- Phospholipid-binding modules such as PH, C1, and C2 domains play crucial roles in location-dependent regulation of many protein kinases. Here, we identify the KA1 domain (kinase associated-1 domain), found at the C termi...
- The Fused/Smurf Complex Controls the Fate of Drosophila Germline Stem Cells by Generating a Gradient BMP Response
[作者：Xia, LX; Jia, SJ; Huang, SJ; Wang, HL; Zhu, YX; Mu, YJ; Kan, LJ; Zheng, WJ; Wu, D; Li, XM; Sun, QM; Meng, AM; Chen, DH,期刊：Cell, 页码：978-990 , 文章类型： Article，,卷期：2010年143-6]
- In the Drosophila ovary, germline stem cells (GSCs) are maintained primarily by bone morphogenetic protein (BMP) ligands produced by the stromal cells of the niche. This signaling represses GSC differentiation by blockin...
- Functional Overlap and Regulatory Links Shape Genetic Interactions between Signaling Pathways
[作者：van Wageningen, S; Kemmeren, P; Lijnzaad, P; Margaritis, T; Benschop, JJ; de Castro, IJ; van Leenen, D; Koerkamp, MJAG; Ko, CW; Miles, AJ; Brabers, N; Brok, MO; Lenstra, TL; Fiedler, D; Fokkens, L; Aldecoa, R; Apweiler, E; Taliadouros, V; Sameith, K; van de Pasch, LAL; van Hooff, SR; Bakker, LV; Krogan, NJ; Snel, B; Holstege, FCP,期刊：Cell, 页码：991-1004 , 文章类型： Article，,卷期：2010年143-6]
- To understand relationships between phosphorylation-based signaling pathways, we analyzed 150 deletion mutants of protein kinases and phosphatases in S. cerevisiae using DNA microarrays. Downstream changes in gene expres...
- An Integrated Approach to Uncover Drivers of Cancer
[作者：Akavia, UD; Litvin, O; Kim, J; Sanchez-Garcia, F; Kotliar, D; Causton, HC; Pochanard, P; Mozes, E; Garraway, LA; Pe'er, D,期刊：Cell, 页码：1005-1017 , 文章类型： Article，,卷期：2010年143-6]
- Systematic characterization of cancer genomes has revealed a staggering number of diverse aberrations that differ among individuals, such that the functional importance and physiological impact of most tumor genetic alte...
- Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation
[作者：Ozsolak, F; Kapranov, P; Foissac, S; Kim, SW; Fishilevich, E; Monaghan, AP; John, B; Milos, PM,期刊：Cell, 页码：1018-1029 , 文章类型： Article，,卷期：2010年143-6]
- The emerging discoveries on the link between polyadenylation and disease states underline the need to fully characterize genome-wide polyadenylation states. Here, we report comprehensive maps of global polyadenylation ev...
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