- Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model
[作者:Becker, JM; Kauffman, SJ; Hauser, M; Huang, LY; Lin, M; Sillaots, S; Jiang, B; Xu, DM; Roemer, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:22044-22049 , 文章类型: Article,,卷期:2010年107-51]
- One potentially rich source of possible targets for antifungal therapy are those Candida albicans genes deemed essential for growth under the standard culture (i.e., in vitro) conditions; however, these genes are largely...
- VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity
[作者:Scherrer, G; Low, SA; Wang, XD; Zhang, J; Yamanaka, H; Urban, R; Solorzano, C; Harper, B; Hnasko, TS; Edwards, RH; Basbaum, AI,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:22296-22301 , 文章类型: Article,,卷期:2010年107-51]
- Dorsal root ganglia (DRG) neurons, including the nociceptors that detect painful thermal, mechanical, and chemical stimuli, transmit information to spinal cord neurons via glutamatergic and peptidergic neurotransmitters....
- A naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogs
[作者:Tretter, EM; Lerman, JC; Berger, JM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:22055-22059 , 文章类型: Article,,卷期:2010年107-51]
- Bacteria frequently possess two type IIA DNA topoisomerases, gyrase and topo IV, which maintain chromosome topology by variously supercoiling, relaxing, and disentangling DNA. DNA recognition and functional output is tho...
- Exquisite sensitivity to subsecond, picomolar nitric oxide transients conferred on cells by guanylyl cyclase-coupled receptors
[作者:Batchelor, AM; Bartus, K; Reynell, C; Constantinou, S; Halvey, EJ; Held, KF; Dostmann, WR; Vernon, J; Garthwaite, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:22060-22065 , 文章类型: Article,,卷期:2010年107-51]
- Nitric oxide (NO) functions as a diffusible transmitter in most tissues of the body and exerts its effects by binding to receptors harboring a guanylyl cyclase transduction domain, resulting in cGMP accumulation in targe...
- A proton current drives action potentials in genetically identified sour taste cells
[作者:Chang, RB; Waters, H; Liman, ER,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:22320-22325 , 文章类型: Article,,卷期:2010年107-51]
- Five tastes have been identified, each of which is transduced by a separate set of taste cells. Of these sour, which is associated with acid stimuli, is the least understood. Genetic ablation experiments have established...
- Structural insights into the activation mechanism of melibiose permease by sodium binding
[作者:Granell, M; Leon, X; Leblanc, G; Padros, E; Lorenz-Fonfria, VA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:22078-22083 , 文章类型: Article,,卷期:2010年107-51]
- The melibiose carrier from Escherichia coli (MelB) couples the accumulation of the disaccharide melibiose to the downhill entry of H+, Na+, or Li+. In this work, substrate-induced FTIR difference spectroscopy was used in...
- Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein
[作者:Yamashita, T; Ohuchi, H; Tomonari, S; Ikeda, K; Sakai, K; Shichida, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:22084-22089 , 文章类型: Article,,卷期:2010年107-51]
- Opn5 (neuropsin) belongs to an independent group separated from the other six groups in the phylogenetic tree of opsins, for which little information of absorption characteristics and molecular properties of the members ...
- Massive alterations of sarcoplasmic reticulum free calcium in skeletal muscle fibers lacking calsequestrin revealed by a genetically encoded probe
[作者:Canato, M; Scorzeto, M; Giacomello, M; Protasi, F; Reggiani, C; Stienen, GJM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:22326-22331 , 文章类型: Article,,卷期:2010年107-51]
- The cytosolic free Ca2+ transients elicited by muscle fiber excitation are well characterized, but little is known about the free [Ca2+] dynamics within the sarcoplasmic reticulum (SR). A targetable ratiometric FRET-base...
- ANK6, a mitochondrial ankyrin repeat protein, is required for male-female gamete recognition in Arabidopsis thaliana
[作者:Yu, F; Shi, J; Zhou, JY; Gu, JN; Chen, QH; Li, JA; Cheng, W; Mao, DD; Tian, LF; Buchanan, BB; Li, LG; Chen, LB; Li, DP; Luan, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:22332-22337 , 文章类型: Article,,卷期:2010年107-51]
- Double fertilization in angiosperms involves several successive steps, including guidance and reception of the pollen tube and male-female gamete recognition. Each step entails extensive communication and interaction bet...
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