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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Structural Characterization of the Multidomain Regulatory Protein Rv1364c from Mycobacterium tuberculosis [作者：King-Scott, J; Konarev, PV; Panjikar, S; Jordanova, R; Svergun, DI; Tucker, PA,期刊：Structure, 页码：56-69 , 文章类型： Article，,卷期：2011年19-1] The open reading frame ry1364c of Mycobacterium tuberculosis, which regulates the stress-dependent a factor, sigma(F), has been analyzed structurally and functionally. Rv1364c contains domains with sequence similarity to... Absence of Ion-Binding Affinity in the Putatively Inactivated Low-[K+] Structure of the KcsA Potassium Channel [作者：Boiteux, C; Berneche, S,期刊：Structure, 页码：70-79 , 文章类型： Article，,卷期：2011年19-1] Potassium channels are membrane proteins that selectively conduct K+ across cellular membranes. The narrowest part of their pore, the selectivity filter, is responsible for distinguishing K+ from Na+, and can also act as... Molecular Insights into gamma delta T Cell Costimulation by an Anti-JAML Antibody [作者：Verdino, P; Witherden, DA; Ferguson, MS; Corper, AL; Schiefner, A; Havran, WL; Wilson, IA,期刊：Structure, 页码：80-89 , 文章类型： Article，,卷期：2011年19-1] gamma delta T cells bridge innate and adaptive immunity and function in immunosurveillance, immunoregulation, tumor cell recognition, and as first line of defense against microbial infection. Costimulation of epithelial ... Mass Spectrometry Reveals Stable Modules in holo and apo RNA Polymerases I and III [作者：Lane, LA; Fernandez-Tornero, C; Zhou, M; Morgner, N; Ptchelkine, D; Steuerwald, U; Politis, A; Lindner, D; Gvozdenovic, J; Gavin, AC; Muller, CW; Robinson, CV,期刊：Structure, 页码：90-100 , 文章类型： Article，,卷期：2011年19-1] RNA polymerases are essential enzymes which transcribe DNA into RNA. Here, we obtain mass spectra of the cellular forms of apo and halo eukaryotic RNA polymerase I and III, defining their composition under different solu... Structural and Biochemical Insights into MLL1 Core Complex Assembly [作者：Avdic, V; Zhang, P; Lanouette, S; Groulx, A; Tremblay, V; Brunzelle, J; Couture, JF,期刊：Structure, 页码：101-108 , 文章类型： Article，,卷期：2011年19-1] Histone H3 Lys-4 methylation is predominantly catalyzed by a family of methyltransferases whose enzymatic activity depends on their interaction with a three-subunit complex composed of WDR5, RbBP5, and Ash2L. Here, we re... SAXS Ensemble Refinement of ESCRT-III CHMP3 Conformational Transitions [作者：Rozycki, B; Kim, YC; Hummer, G,期刊：Structure, 页码：109-116 , 文章类型： Article，,卷期：2011年19-1] We developed and implemented an ensemble-refinement method to study dynamic biomolecular assemblies with intrinsically disordered segments. Data from small angle X-ray scattering (SAXS) experiments and from coarse-graine... Separation-of-Function Mutants Unravel the Dual-Reaction Mode of Human 8-Oxoguanine DNA Glycosylase [作者：Dalhus, B; Forsbring, M; Helle, IH; Vik, ES; Forstrom, RJ; Backe, PH; Alseth, I; Bjoras, M,期刊：Structure, 页码：117-127 , 文章类型： Article，,卷期：2011年19-1] 7,8-Dihydro-8-oxoguanine (8oxoG) is a major mutagenic base lesion formed when reactive oxygen species react with guanine in DNA. The human 8oxoG DNA glycosylase (hOgg1) recognizes and initiates repair of 8oxoG. hOgg1 is ... Structyre of the Drosophila Apoptosome at 6.9 angstrom Resolution [作者：Yuan, SJ; Yu, XC; Topf, M; Dorstyn, L; Kumar, S; Ludtke, SJ; Akey, CW,期刊：Structure, 页码：128-140 , 文章类型： Article，,卷期：2011年19-1] The Drosophila Apaf-1 related killer forms an apoptosome in the intrinsic cell death pathway. In this study we show that Dark forms a single ring when initiator procaspases are bound. This Dark-Dronc complex cleaves DrIC... Cytokine Signaling Exposed [作者：Hubbard, SR,期刊：Structure, 页码：1-2 , 文章类型： Editorial Material，,卷期：2011年19-1] In this issue, Lupardus et al. (2011) provide images, obtained by electron microscopy, of a complete cytokine signaling complex, offering clues into the mechanism by which binding of cytokines to their cognate receptors ... EROS: Better than SAXS! [作者：Yang, SC; Roux, B,期刊：Structure, 页码：3-4 , 文章类型： Editorial Material，,卷期：2011年19-1] DARK Apoptosome Secrets Come to Light [作者：Wu, CC; Bratton, SB,期刊：Structure, 页码：4-6 , 文章类型： Editorial Material，,卷期：2011年19-1] In this issue of Structure, Yuan et al. (2011) utilize biochemical approaches to reconstitute an active Drosophila apoptosome, as well as cryo-electron microscopy to generate an improved model for this conserved caspase-... Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification [作者：Stoddard, BL,期刊：Structure, 页码：7-15 , 文章类型： Review，,卷期：2011年19-1] Homing endonucleases are microbial DNA-cleaving enzymes that mobilize their own reading frames by generating double strand breaks at specific genomic invasion sites. These proteins display an economy of size, and yet rec... Benchmarking Membrane Protein Detergent Stability for Improving Throughput of High-Resolution X-ray Structures [作者：Sonoda, Y; Newstead, S; Hu, NJ; Alguel, Y; Nji, E; Beis, K; Yashiro, S; Lee, C; Leung, J; Cameron, AD; Byrne, B; Iwata, S; Drew, D,期刊：Structure, 页码：17-25 , 文章类型： Article，,卷期：2011年19-1] Obtaining well-ordered crystals is a major hurdle to X-ray structure determination of membrane proteins. To facilitate crystal optimization, we investigated the detergent stability of 24 eukaryotic and prokaryotic membra... Portrayal of Complex Dynamic Properties of Sugarcane Defensin 5 by NMR: Multiple Motions Associated with Membrane Interaction [作者：de Paula, VS; Razzera, G; Barreto-Bergter, E; Almeida, FCL; Valente, AP,期刊：Structure, 页码：26-36 , 文章类型： Article，,卷期：2011年19-1] Defensins are essentially ancient natural antibiotics with potent activity extending from lower organisms to humans. Sd5 is a recently described antifungal defensin that appears to be the result of a recent gain of funct... Helix 11 Dynamics Is Critical for Constitutive Androstane Receptor Activity [作者：Wright, E; Busby, SA; Wisecarver, S; Vincent, J; Griffin, PR; Fernandez, EJ,期刊：Structure, 页码：37-44 , 文章类型： Article，,卷期：2011年19-1] The constitutive androstane receptor (CAR) transactivation can occur in the absence of exogenous ligand and this activity is enhanced by agonists TCPOBOP and meclizine. We use biophysical and cell-based assays to show th... Structural Snapshots of Full-Length Jak1, a Transmembrane gp130/IL-6/IL-6R alpha Cytokine Receptor Complex, and the Receptor-Jak1 Holocomplex [作者：Lupardus, PJ; Skiniotis, G; Rice, AJ; Thomas, C; Fischer, S; Walz, T; Garcia, KC,期刊：Structure, 页码：45-55 , 文章类型： Article，,卷期：2011年19-1] The shared cytokine receptor gp130 signals as a homodimer or heterodimer through activation of Janus kinases (Jaks) associated with the receptor intracellular domains. Here, we reconstitute, in parts and whole, the full-...