- Superparamagnetic Iron Oxide Nanotheranostics for Targeted Cancer Cell Imaging and pH-Dependent Intracellular Drug Release
[作者:Zou, P; Yu, YK; Wang, YA; Zhong, YQ; Welton, A; Galban, C; Wang, SM; Sun, DX,期刊:Molecular Pharmaceutics, 页码:1974-1984 , 文章类型: Article,,卷期:2010年7-6]
- Studies were conducted to develop antibody-and fluorescence-labeled superparamagnetic iron oxide nanoparticle (SPIO) nanotheranostics for magnetic resonance imaging (MRI) and fluorescence imaging of cancer cells and pH-d...
- Molecular Insights on the Cyclic Peptide Nanotube-Mediated Transportation of Antitumor Drug 5-Fluorouracil
[作者:Liu, HF; Chen, JA; Shen, Q; Fu, W; Wu, W,期刊:Molecular Pharmaceutics, 页码:1985-1994 , 文章类型: Article,,卷期:2010年7-6]
- Self-assembled cyclic peptide nanotubes (CPNs) show a potential use in drug delivery. In this study, the CPN composed of (Trp-D-Leu)(4)-Gln-D-Leu was synthesized and tested for the transport of the antitumor drug 5-fluor...
- Specificity of a Prodrug-Activating Enzyme hVACVase: The Leaving Group Effect
[作者:Sun, J; Dahan, A; Walls, ZF; Lai, LS; Lee, KD; Amidon, GL,期刊:Molecular Pharmaceutics, 页码:2362-2368 , 文章类型: Article,,卷期:2010年7-6]
- Human valacyclovirase (hVACVase) is a prodrug-activating enzyme for amino acid prodrugs including the antiviral drugs valacyclovir and valganciclovir. In hVACVase-catalyzed reactions, the leaving group of the substrate c...
- Evolutionary Selection of New Breast Cancer Cell-Targeting Peptides and Phages with the Cell-Targeting Peptides Fully Displayed on the Major Coat and Their Effects on Actin Dynamics during Cell Internalization (vol 7, pg 1629, 2010)
[作者:Abbineni, G; Modali, S; Safiejko-Mroczka, B; Petrenko, VA; Mao, CB,期刊:Molecular Pharmaceutics, 页码:2369-2369 , 文章类型: Correction,,卷期:2010年7-6]
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- Lactoferrin-Conjugated Biodegradable Polymersome Holding Doxorubicin and Tetrandrine for Chemotherapy of Glioma Rats
[作者:Pang, ZQ; Feng, LA; Hua, RR; Chen, J; Gao, HL; Pan, SQ; Jiang, XG; Zhang, P,期刊:Molecular Pharmaceutics, 页码:1995-2005 , 文章类型: Article,,卷期:2010年7-6]
- The blood-brain barrier (BBB) and multidrug resistance (MDR) are the main causes for poor prognosis of glioma patients after chemotherapy. To explore the way for settling this problem, in this study, a novel antitumor ag...
- Pulsed Ultrasound Enhances Nanoparticle Penetration into Breast Cancer Spheroids
[作者:Grainger, SJ; Serna, JV; Sunny, S; Zhou, Y; Deng, CX; El-Sayed, MEH,期刊:Molecular Pharmaceutics, 页码:2006-2019 , 文章类型: Article,,卷期:2010年7-6]
- Effective treatment of solid tumors requires homogeneous distribution of anticancer drugs within the entire tumor volume to deliver lethal concentrations to resistant cancer cells and tumor-initiating cancer stem cells. ...
- Multimodal Clinical Imaging To Longitudinally Assess a Nanomedical Anti-Inflammatory Treatment in Experimental Atherosclerosis
[作者:Lobatto, ME; Fayad, ZA; Silvera, S; Vucic, E; Calcagno, C; Mani, V; Dickson, SD; Nicolay, K; Banciu, M; Schiffelers, RM; Metselaar, JM; van Bloois, L; Wu, HS; Fallon, JT; Rudd, JH; Fuster, V; Fisher, EA; Storm, G; Mulder, WJM,期刊:Molecular Pharmaceutics, 页码:2020-2029 , 文章类型: Article,,卷期:2010年7-6]
- Atherosclerosis is an inflammatory disease causing great morbidity and mortality in the Western world. To increase the anti-inflammatory action and decrease adverse effects of glucocorticoids (PLP), a nanomedicinal lipos...
- Bioresponsive Small Molecule Polyamines as Noncytotoxic Alternative to Polyethylenimine
[作者:Drake, CR; Aissaoui, A; Argyros, O; Serginson, JM; Monnery, BD; Thanou, M; Steinke, JHG; Miller, AD,期刊:Molecular Pharmaceutics, 页码:2040-2055 , 文章类型: Article,,卷期:2010年7-6]
- Nonviral gene therapy continues to require novel synthetic vectors to deliver therapeutic nucleic acids effectively and safely. The majority of synthetic nonviral vectors employed in clinical trials to date have been cat...
- Improvement of Insulin Resistance by Removal of Systemic Hydrogen Peroxide by PEGylated Catalase in Obese Mice
[作者:Ikemura, M; Nishikawa, M; Hyoudou, K; Kobayashi, Y; Yamashita, F; Hashida, M,期刊:Molecular Pharmaceutics, 页码:2069-2076 , 文章类型: Article,,卷期:2010年7-6]
- Insulin resistance, a condition in which insulin action is impaired, is one of the characteristic features of type 2 diabetes. Excessive amounts of reactive oxygen species (ROS) interfere with the insulin signaling pathw...
- Transport and Metabolism of Radiolabeled Choline in Hepatocellular Carcinoma
[作者:Kuang, Y; Salem, N; Corn, DJ; Erokwu, B; Tian, HB; Wang, FJ; Lee, ZH,期刊:Molecular Pharmaceutics, 页码:2077-2092 , 文章类型: Article,,卷期:2010年7-6]
- Altered choline (Cho) metabolism in cancerous cells can be used as a basis for molecular imaging with PET using radiolabeled Cho. In this study, the metabolism of tracer Cho was investigated in a woodchuck hepatocellular...
- Studies on Cellular Accumulation of Satraplatin and Its Major Metabolite JM118 and Their Interactions with Glutathione
[作者:Kostrhunova, H; Kasparkova, J; Gibson, D; Brabec, V,期刊:Molecular Pharmaceutics, 页码:2093-2102 , 文章类型: Article,,卷期:2010年7-6]
- Before the active form of a Pt drug reaches its major pharmacological target in the cell nucleus, the Pt complex has to accumulate in cells, and during its transportation into cells and inside cells, it reacts with vario...
- A Three-Dimensional Coculture of Enterocytes, Monocytes and Dendritic Cells To Model Inflamed Intestinal Mucosa in Vitro
[作者:Leonard, F; Collnot, EM; Lehr, CM,期刊:Molecular Pharmaceutics, 页码:2103-2119 , 文章类型: Article,,卷期:2010年7-6]
- While epithelial cell culture models (e.g., Caco-2 cell line) are widely used to assess the absorption of drug molecules across healthy intestinal mucosa, there are no suitable in vitro models of the intestinal barrier i...
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