- BLIMP1 against Lymphoma: The Verdict Is Reached
[作者：Lossos, IS,期刊：Cancer Cell, 页码：537-539 , 文章类型： Editorial Material，,卷期：2010年18-6]
- BLIMP1, a master regulator of plasma-cell differentiation, is implicated in the pathogenesis of Activated B cell (ABC)-like Diffuse Large B cell Lymphoma (DLBCL). In this issue of Cancer Cell, Mandelbaum and colleagues a...
- The Ids Have It
[作者：Edwards, LA; Fine, HA,期刊：Cancer Cell, 页码：543-545 , 文章类型： Editorial Material，,卷期：2010年18-6]
- In this issue of Cancer Cell, Anido et al. demonstrate that Id1 is the likely arbiter of divergent transforming growth factor-beta (TGF-beta) signaling in glioma-initiating cells (GICs) from different tumors. These findi...
- Constitutive Canonical NF-kappa B Activation Cooperates with Disruption of BLIMP1 in the Pathogenesis of Activated B Cell-like Diffuse Large Cell Lymphoma
[作者：Calado, DP; Zhang, BC; Srinivasan, L; Sasaki, Y; Seagal, J; Unitt, C; Rodig, S; Kutok, J; Tarakhovsky, A; Schmidt-Supprian, M; Rajewsky, K,期刊：Cancer Cell, 页码：580-589 , 文章类型： Article，,卷期：2010年18-6]
- Diffuse large B cell lymphoma (DLBCL) comprises disease entities with distinct genetic profiles, including germinal center B cell (GCB)-like and activated B cell (ABC)-like DLBCLs. Major differences between these two sub...
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
[作者：Figueroa, ME; Abdel-Wahab, O; Lu, C; Ward, PS; Patel, J; Shih, A; Li, YS; Bhagwat, N; Vasanthakumar, A; Fernandez, HF; Tallman, MS; Sun, ZX; Wolniak, K; Peeters, JK; Liu, W; Choe, SE; Fantin, VR; Paietta, E; Lowenberg, B; Licht, JD; Godley, LA; Delwel, R; Valk, PJM; Thompson, CB; Levine, RL; Melnick, A,期刊：Cancer Cell, 页码：553-567 , 文章类型： Article，,卷期：2010年18-6]
- Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large acute myeloid leukemia (AML) patient cohor...
- BLIMP1 Is a Tumor Suppressor Gene Frequently Disrupted in Activated B Cell-like Diffuse Large B Cell Lymphoma
[作者：Mandelbaum, J; Bhagat, G; Tang, HY; Mo, TW; Brahmachary, M; Shen, QO; Chadburn, A; Rajewsky, K; Tarakhovsky, A; Pasqualucci, L; Dalla-Favera, R,期刊：Cancer Cell, 页码：568-579 , 文章类型： Article，,卷期：2010年18-6]
- Diffuse large B cell lymphoma (DLBCL) is a heterogeneous disease composed of at least two distinct subtypes: germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL. These phenotypic subtypes segregate wi...
- Effective Suppression of Vascular Network Formation by Combination of Antibodies Blocking VEGFR Ligand Binding and Receptor Dimerization
[作者：Tvorogov, D; Anisimov, A; Zheng, W; Leppanen, VM; Tammela, T; Laurinavicius, S; Holnthoner, W; Helotera, H; Holopainen, T; Jeltsch, M; Kalkkinen, N; Lankinen, H; Ojala, PM; Alitalo, K,期刊：Cancer Cell, 页码：630-640 , 文章类型： Article，,卷期：2010年18-6]
- Antibodies that block vascular endothelial growth factor (VEGF) have become an integral part of antiangiogenic tumor therapy, and antibodies targeting other VEGFs and receptors (VEGFRs) are in clinical trials. Typically ...
- Cooperative Epigenetic Modulation by Cancer Amplicon Genes
[作者：Rui, LX; Emre, NCT; Kruhlak, MJ; Chung, HJ; Steidl, C; Slack, G; Wright, GW; Lenz, G; Ngo, VN; Shaffer, AL; Xu, WH; Zhao, H; Yang, YD; Lamy, L; Davis, RE; Xiao, WM; Powell, J; Maloney, D; Thomas, CJ; Moller, P; Rosenwald, A; Ott, G; Muller-Hermelink, HK; Savage, K; Connors, JM; Rimsza, LM; Campo, E; Jaffe, ES; Delabie, J; Smeland, EB; Weisenburger, DD; Chan, WC; Gascoyne, RD; Levens, D; Staudt, LM,期刊：Cancer Cell, 页码：590-605 , 文章类型： Article，,卷期：2010年18-6]
- Chromosome band 9p24 is frequently amplified in primary mediastinal B cell lymphoma (PMBL) and Hodgkin lymphoma (HL). To identify oncogenes in this amplicon, we screened an RNA interference library targeting amplicon gen...
- beta-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells
[作者：Yeung, J; Esposito, MT; Gandillet, A; Zeisig, BB; Griessinger, E; Bonnet, D; So, CWE,期刊：Cancer Cell, 页码：606-618 , 文章类型： Article，,卷期：2010年18-6]
- Identification of molecular pathways essential for cancer stem cells is critical for understanding the underlying biology and designing effective cancer therapeutics. Here, we demonstrated that beta-catenin was activated...
- Loss of ATM/Chk2/p53 Pathway Components Accelerates Tumor Development and Contributes to Radiation Resistance in Gliomas
[作者：Squatrito, M; Brennan, CW; Helmy, K; Huse, JT; Petrini, JH; Holland, EC,期刊：Cancer Cell, 页码：619-629 , 文章类型： Article，,卷期：2010年18-6]
- Maintenance of genomic integrity is essential for adult tissue homeostasis and defects in the DNA-damage response (DDR) machinery are linked to numerous pathologies including cancer. Here, we present evidence that the DD...
- Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55 alpha,delta Phosphatase
[作者：Manchado, E; Guillamot, M; de Carcer, G; Eguren, M; Trickey, M; Garcia-Higuera, I; Moreno, S; Yamano, H; Canamero, M; Malumbres, M,期刊：Cancer Cell, 页码：641-654 , 文章类型： Article，,卷期：2010年18-6]
- Targeting mitotic exit has been recently proposed as a relevant therapeutic approach against cancer. By using genetically engineered mice, we show that the APC/C cofactor Cdc20 is essential for anaphase onset in vivo in ...
- TGF-beta Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma
[作者：Anido, J; Saez-Borderias, A; Gonzalez-Junca, A; Rodon, L; Folch, G; Carmona, MA; Prieto-Sanchez, RM; Barba, I; Martinez-Saez, E; Prudkin, L; Cuartas, I; Raventos, C; Martinez-Ricarte, F; Poca, MA; Garcia-Dorado, D; Lahn, MM; Yingling, JM; Rodon, J; Sahuquillo, J; Baselga, J; Seoane, J,期刊：Cancer Cell, 页码：655-668 , 文章类型： Article，,卷期：2010年18-6]
- Glioma-initiating cells (GICs), also called glioma stem cells, are responsible for tumor initiation, relapse, and therapeutic resistance. Here, we show that TGF-beta inhibitors, currently under clinical development, targ...
- Non-Stem Cell Origin for Oligodendroglioma
[作者：Persson, AI; Petritsch, C; Swartling, FJ; Itsara, M; Sim, FJ; Auvergne, R; Goldenberg, DD; Vandenberg, SR; Nguyen, KN; Yakovenko, S; Ayers-Ringler, J; Nishiyama, A; Stallcup, WB; Berger, MS; Bergers, G; McKnight, TR; Goldman, SA; Weiss, WA,期刊：Cancer Cell, 页码：669-682 , 文章类型： Article，,卷期：2010年18-6]
- Malignant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor outcome. Malignant oligodendroglial ...
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