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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Focused ultrasound and microbubbles for enhanced extravasation [作者：Bohmer, MR; Chlon, CHT; Raju, BI; Chin, CT; Shevchenko, T; Klibanov, AL,期刊：Journal of controlled release, 页码：18-24 , 文章类型： Proceedings Paper，,卷期：2010年148-1] The permeability of blood vessels for albumin can be altered by using ultrasound and polymer or lipid-shelled microbubbles. The region in which the microbubbles were destroyed with focused ultrasound was quantified in ge... Ultrasound triggered, image guided, local drug delivery [作者：Deckers, R; Moonen, CTW,期刊：Journal of controlled release, 页码：25-33 , 文章类型： Proceedings Paper，,卷期：2010年148-1] Ultrasound allows the deposition of thermal and mechanical energies deep inside the human body in a non-invasive way. Ultrasound can be focused within a region with a diameter of about 1 mm. The bio-effects of ultrasound... Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins [作者：Seck, TM; Melchels, FPW; Feijen, J; Grijpma, DW,期刊：Journal of controlled release, 页码：34-41 , 文章类型： Proceedings Paper，,卷期：2010年148-1] Designed three-dimensional biodegradable poly(ethylene glycol)/poly(D,L-lactide) hydrogel structures were prepared for the first time by stereolithography at high resolutions. A photo-polymerisable aqueous resin comprisi... Advanced fluorescence microscopy methods illuminate the transfection pathway of nucleic acid nanoparticles [作者：Braeckmans, K; Buyens, K; Naeye, B; Vercauteren, D; Deschout, H; Raemdonck, K; Remaut, K; Sanders, NN; Demeester, J; De Smedt, SC,期刊：Journal of controlled release, 页码：69-74 , 文章类型： Proceedings Paper，,卷期：2010年148-1] A great deal of attention in biopharmacy and pharmaceutical technology is going to the development of nanoscopic particles to efficiently deliver nucleic acids to target cells. Despite the great potential of nucleic acid... Effects of charge density and hydrophobicity of poly(amido amine)s for non-viral gene delivery [作者：Piest, M; Engbersen, JFJ,期刊：Journal of controlled release, 页码：83-90 , 文章类型： Proceedings Paper，,卷期：2010年148-1] High cationic charge densities in polymeric vectors result in tight DNA condensation, leading to small highly positively charged polyplexes which show generally high cellular uptake in vitro. However, high cationic charg... Barrier analysis of periocular drug delivery to the posterior segment [作者：Ranta, VP; Mannermaa, E; Lummepuro, K; Subrizi, A; Laukkanen, A; Antopolsky, M; Murtomaki, L; Hornof, M; Urtti, A,期刊：Journal of controlled release, 页码：42-48 , 文章类型： Proceedings Paper，,卷期：2010年148-1] Periocular administration is a potential way of delivering drugs to their targets in posterior eye segment (vitreous, neural retina, retinal pigment epithelium (RPE), choroid). Purpose of this study was to evaluate the r... Fibrin glue as a drug delivery system [作者：Spicer, PP; Mikos, AG,期刊：Journal of controlled release, 页码：49-55 , 文章类型： Proceedings Paper，,卷期：2010年148-1] Fibrin glue has been used surgically for decades for hemostasis as well as a sealant. It has also been researched as both a gel for cell delivery and a vehicle for drug delivery. The drug delivery applications for fibrin... Induction of therapeutic gene silencing in leukocyte-implicated diseases by targeted and stabilized nanoparticles: A mini-review [作者：Peer, D,期刊：Journal of controlled release, 页码：63-68 , 文章类型： Proceedings Paper，,卷期：2010年148-1] RNA interference (RNAi) is a highly conserved endogenous mechanism that uses small RNA species to guide the sequence-specific silencing of gene expression. The discovery that RNAi functions in mammalian cells to regulate... Extended release of dexamethasone from silicone-hydrogel contact lenses containing vitamin E [作者：Kim, J; Peng, CC; Chauhan, A,期刊：Journal of controlled release, 页码：110-116 , 文章类型： Proceedings Paper，,卷期：2010年148-1] Ophthalmic drug delivery by contact lenses is expected to be more efficient due to continuous extended release of drug and increased residence time in the tear film. However, commercial contact lenses release ophthalmic ... Gold nanoparticle platforms as drug and biomacromolecule delivery systems [作者：Duncan, B; Kim, C; Rotello, VM,期刊：Journal of controlled release, 页码：122-127 , 文章类型： Proceedings Paper，,卷期：2010年148-1] Gold nanoparticles (AuNPs) are a suitable platform for development of efficient delivery systems. AuNPs can be easily synthesized, functionalized, and are biocompatible. The tunability of the AuNP monolayer allows for co... Tumor therapy by gene regulation system responding to cellular signal [作者：Tomiyama, T; Toita, R; Kang, JH; Asai, D; Shiosaki, S; Mori, T; Niidome, T; Katayama, Y,期刊：Journal of controlled release, 页码：101-105 , 文章类型： Proceedings Paper，,卷期：2010年148-1] For safe and efficient gene therapy, the development of gene delivery systems to specifically target tumor cells is one of the most important issues regarding present gene delivery methodologies. Recently, we have develo... A method for quantifying cellular uptake of fluorescently labeled siRNA [作者：Vader, P; van der Aa, LJ; Engbersen, JFJ; Storm, G; Schiffelers, RM,期刊：Journal of controlled release, 页码：106-109 , 文章类型： Proceedings Paper，,卷期：2010年148-1] Efficient intracellular delivery of siRNA is a significant hurdle to its therapeutic success. For biological studies on the efficiency of carrier-mediated uptake of siRNA, quantitative determination of the amount of inte... Special Issue: 11th European Symposium on Controlled Drug Delivery Preface [作者：Engbersen, JFJ,期刊：Journal of controlled release, 页码：1-1 , 文章类型： Editorial Material，,卷期：2010年148-1] Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules [作者：Selbo, PK; Weyergang, A; Hogset, A; Norum, OJ; Berstad, MB; Vikdal, M; Berg, K,期刊：Journal of controlled release, 页码：2-12 , 文章类型： Proceedings Paper，,卷期：2010年148-1] A successful cure of cancer by biopharmaceuticals with intracellular targets is dependent on both specific and sufficient delivery of the drug to the cytosol or nuclei of malignant cells. However, cytosolic delivery and ... Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: A tool for targeted drug delivery [作者：Klibanov, AL; Shevchenko, TI; Raju, BI; Seip, R; Chin, CT,期刊：Journal of controlled release, 页码：13-17 , 文章类型： Proceedings Paper，,卷期：2010年148-1] We investigated the preparation of ultrasound-triggered drug delivery system, based on a pendant complex of microbubble coated with liposomes. Biotinylated decafluorobutane microbubbles were coated with biotinylated lipo... Lympho-geographical concepts in vaccine delivery [作者：Johansen, P; Mohanan, D; Martinez-Gomez, JM; Kundig, TM; Gander, B,期刊：Journal of controlled release, 页码：56-62 , 文章类型： Proceedings Paper，,卷期：2010年148-1] The key triggers and regulators of immune responses are antigens and their appearance in immune-privileged secondary lymphatic organs. Currently, the majority of vaccines are administered intramuscularly or subcutaneousl...