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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   Role of Medicines in Malaria Control and Elimination [作者：Warsame, M; Olumese, P; Mendis, K,期刊：Drug Development Research, 页码：4-11 , 文章类型： Article，,卷期：2010年71-1] Antimalarial medicines constitute important tools to cure and prevent malaria infections, thereby averting death and disability; their role in reducing the transmission of malaria is becoming increasingly important. Effe... Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design [作者：Muregi, FW; Ishih, A,期刊：Drug Development Research, 页码：20-32 , 文章类型： Article，,卷期：2010年71-1] Malaria is a disease that affects nearly 40% of the global population, and chemotherapy remains the mainstay of its control strategy. The global malaria situation is increasingly being exacerbated by the emergence of dru... Artesunate Plus Amodiaquine Combination Therapy: Reviewing the Evidence [作者：Adjei, GO; Kudzi, W; Dodoo, A; Kurtzhals, JAL,期刊：Drug Development Research, 页码：33-43 , 文章类型： Article，,卷期：2010年71-1] The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed-dose combination of artemether-lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first-line the... Targeting the Lipid Metabolic Pathways for the Treatment of Malaria [作者：Ben Mamoun, C; Prigge, ST; Vial, H,期刊：Drug Development Research, 页码：44-55 , 文章类型： Article，,卷期：2010年71-1] The control and eventual eradication of human malaria is considered one of the most important global public health goals of the 21st Century. Malaria, caused by intraerythrocytic protozoan parasites of the genus Plasmodi... Which Drug is Effective and Safe for Acute Malaria in Pregnancy? Reviewing the Evidence [作者：McGready, R; Nosten, F,期刊：Drug Development Research, 页码：56-68 , 文章类型： Article，,卷期：2010年71-1] During pregnancy, a woman living or travelling in a malaria endemic area is more at risk of contracting the disease and developing a severe infection and dying than a non-pregnant woman. Despite this increased morbidity ... Antiparasitic and Immunomodulatory Activities of 1,1-bis(4-Hydroxyphenyl)-2-Phenyl-but-1-ene and Its Protected and Free 2-Ferrocenyl Derivatives [作者：Soares, MBP; Costa, JFO; de Sa, MS; Ribeiro-Dos-Santos, R; Pigeon, P; Jaouen, G; Santana, AEG; Goulart, MOF; Hillard, E,期刊：Drug Development Research, 页码：69-75 , 文章类型： Article，,卷期：2010年71-1] The ferrocenyl diphenol 1 [1,1-bis(4-hydroxyphenyl)-2-ferrocenyl-but-1-ene] displays strong cytotoxic effects against a variety of cancer cells. In the present study we have evaluated the immunomodulatory and antiparasit... Antimalarial Preclinical Drug Development: A Single Oral Dose of a 5-Carbon-Linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice [作者：Moon, DK; Singhal, V; Kumar, N; Shapiro, TA; Posner, GH,期刊：Drug Development Research, 页码：76-81 , 文章类型： Article，,卷期：2010年71-1] Three new 5-carbon-linked trioxane dimer carboxylate esters have been prepared from the natural trioxane, artemisinin, in only three steps and 40-50% overall yields. Each one of these new chemical entities is at least as... Antimalarial Activity of Compounds and Mixed Fractions of Cecropia pachystachya [作者：Uchoa, VT; de Paula, RC; Krettli, LG; Santana, AEG; Krettli, AU,期刊：Drug Development Research, 页码：82-91 , 文章类型： Article，,卷期：2010年71-1] Extracts from Cecropia pachystachya (Cecropiaceae), a medicinal plant used in Brazil, were tested for their antimalarial activity against Plasmodium falciparum and/or Plasmodium berghei in mice. The ethanol extracts of w... Gaining Time: Early Treatment of Severe Pediatric Malaria in Tanzania [作者：Gomes, MF; Warsame, M; Nasemba, N; Singlovic, J; Kapinga, A; Mwankuyse, S; Mduma, S; Msabaha, MH; Mulokosi, F; Shishira, J; Kitua, A; Mrango, Z,期刊：Drug Development Research, 页码：92-98 , 文章类型： Article，,卷期：2010年71-1] Early effective treatment prevents death or disability from malaria. In malaria-endemic rural areas, pediatric patients who cannot take drugs orally and require injectable treatment have to be transported to the nearest ... Malaria Drugs: Clues From Malaria Resistance Genetics [作者：Gurwitz, D,期刊：Drug Development Research, 页码：1-3 , 文章类型： Editorial Material，,卷期：2010年71-1] New treatments for malaria are desperately needed. Malaria drug design can be assisted by knowledge on protective host genotypes. Individuals immune to severe malaria, being only mildly affected by the parasite infection... Artemisinin Antimalarials: Preserving the "Magic Bullet" [作者：Maude, RJ; Woodrow, CJ; White, LJ,期刊：Drug Development Research, 页码：12-19 , 文章类型： Review，,卷期：2010年71-1] The artemisinins are the most effective antimalarial drugs known. They possess a remarkably wide therapeutic index. These agents have been used in traditional Chinese herbal medicine for more than 2,000 years but were no...