- Recent Advances in Structural Studies of the Carbonic Anhydrase Family: The Crystal Structure of Human CA IX and CA XIII
[作者：Supuran, CT; Di Fiore, A; Alterio, V; Monti, SM; De Simone, G,期刊：Current Pharmaceutical Design, 页码：3246-3254 , 文章类型： Review，,卷期：2010年16-29]
- The carbonic anhydrase (CA) family has recently become an important target for the drug design of inhibitors with potential use as diagnostic and therapeutic tools. However, given the high degree of sequence and structur...
- The beta-Carbonic Anhydrases from Mycobacterium tuberculosis as Drug Targets
[作者：Nishimori, I; Minakuchi, T; Maresca, A; Carta, F; Scozzafava, A; Supuran, CT,期刊：Current Pharmaceutical Design, 页码：3300-3309 , 文章类型： Review，,卷期：2010年16-29]
- Three beta-carbonic anhydrases (CAs, EC 4.2.1.1), encoded by the gene Rv1284 (mtCA 1) Rv3588c (mtCA 2) and Rv3273 (mtCA 3) are present in the human pathogen Mycobacterium tuberculosis. These enzymes were cloned and they ...
- Carbonic Anhydrase Inhibitors Developed Through 'Click Tailing'
[作者：Lopez, M; Salmon, AJ; Supuran, CT; Poulsen, SA,期刊：Current Pharmaceutical Design, 页码：3277-3287 , 文章类型： Review，,卷期：2010年16-29]
- In recent years there has been renewed activity in the literature concerning the 1,3-dipolar cycloaddition reaction (1,3-DCR) of organic azides (R-N-3) with alkynes (R'-C CH) to form 1,2,3-triazoles, i.e. the Huisgen sy...
- Brucella Carbonic Anhydrases: New Targets for Designing Anti-Infective Agents
[作者：Winum, JY; Kohler, S; Supuran, CT,期刊：Current Pharmaceutical Design, 页码：3310-3316 , 文章类型： Review，,卷期：2010年16-29]
- The facultative intracellular pathogen and zoonotic agent Brucella sp. possesses two carbonic anhydrases (CAs, EC 4.2.1.1), termed bsCA I and bsCA II (in Brucella suis), belonging to the beta-class of these metalloprotei...
- 3-Phenyl-1H-Indole-5-Sulfonamides: Structure-Based Drug Design of a Promising Class of Carbonic Anhydrase Inhibitors
[作者：Guzel, O; Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT,期刊：Current Pharmaceutical Design, 页码：3317-3326 , 文章类型： Review，,卷期：2010年16-29]
- A series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides possessing various 2-, 3- or 4-substituted phenyl groups with methyl-, halogeno- and methoxy-functionalities, as well as the perfluorophenyl...
- Saccharomyces cerevisiae beta-Carbonic Anhydrase: Inhibition and Activation Studies
[作者：Isik, S; Guler, OO; Kockar, F; Aydin, M; Arslan, O; Supuran, CT,期刊：Current Pharmaceutical Design, 页码：3327-3336 , 文章类型： Review，,卷期：2010年16-29]
- The beta-carbonic anhydrase from Saccharomyces cerevisiae (CA, EC 4.2.1.1), scCA, which is encoded by the Nce103 gene, is an effective catalyst for CO2 hydration to bicarbonate and protons, with a k(cat) of 9.4 x 10(5) s...
- Carbonic Anhydrase IX as an Anticancer Therapy Target: Preclinical Evaluation of Internalizing Monoclonal Antibody Directed to Catalytic Domain
[作者：Zatovicova, M; Jelenska, L; Hulikova, A; Csaderova, L; Ditte, Z; Ditte, P; Goliasova, T; Pastorek, J; Pastorekova, S,期刊：Current Pharmaceutical Design, 页码：3255-3263 , 文章类型： Review，,卷期：2010年16-29]
- Carbonic anhydrase IX (CA IX) is a suitable target for various anticancer strategies. It is a cell surface protein that is present in human tumors, but not in the corresponding normal tissues. Expression of CA IX is indu...
- Modulation of Carbonic Anhydrase 9 (CA9) in Human Brain Cancer
[作者：Said, HM; Supuran, CT; Hageman, C; Staab, A; Polat, B; Katzer, A; Scozzafava, A; Anacker, J; Flentje, M; Vordermark, D,期刊：Current Pharmaceutical Design, 页码：3288-3299 , 文章类型： Review，,卷期：2010年16-29]
- Hypoxia is a crucial factor in tumour aggressiveness and its treatment resistance, particularly in human brain cancer. Tumour resistance against radiation- and chemo- therapy is facilitated by oxygenation reduction at tu...
|