- Navigating transformations in governance of Chilean marine coastal resources
[作者:Gelcich, S; Hughes, TP; Olsson, P; Folke, C; Defeo, O; Fernandez, M; Foale, S; Gunderson, LH; Rodriguez-Sickert, C; Scheffer, M; Steneck, RS; Castilla, JC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16794-16799 , 文章类型: Article,,卷期:2010年107-39]
- Marine ecosystems are in decline. New transformational changes in governance are urgently required to cope with overfishing, pollution, global changes, and other drivers of degradation. Here we explore social, political,...
- RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory
[作者:Lee, SE; Simons, SB; Heldt, SA; Zhao, ML; Schroeder, JP; Vellano, CP; Cowan, DP; Ramineni, S; Yates, CK; Feng, Y; Smith, Y; Sweatt, D; Weinshenker, D; Ressler, KJ; Dudek, SM; Hepler, JR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16994-16998 , 文章类型: Article,,卷期:2010年107-39]
- Learning and memory have been closely linked to strengthening of synaptic connections between neurons (i.e., synaptic plasticity) within the dentate gyrus (DG)-CA3-CA1 trisynaptic circuit of the hippocampus. Conspicuousl...
- MHC class I molecules are present both pre- and postsynaptically in the visual cortex during postnatal development and in adulthood
[作者:Needleman, LA; Liu, XB; El-Sabeawy, F; Jones, EG; McAllister, AK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16999-17004 , 文章类型: Article,,卷期:2010年107-39]
- Immune molecules have been discovered recently to play critical roles in the development, function, and plasticity of the cerebral cortex. MHC class I (MHCI) molecules are expressed in the central nervous system and regu...
- Probing electron transfer mechanisms in Shewanella oneidensis MR-1 using a nanoelectrode platform and single-cell imaging
[作者:Jiang, XC; Hu, JS; Fitzgerald, LA; Biffinger, JC; Xie, P; Ringeisen, BR; Lieber, CM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16806-16810 , 文章类型: Article,,卷期:2010年107-39]
- Microbial fuel cells (MFCs) represent a promising approach for sustainable energy production as they generate electricity directly from metabolism of organic substrates without the need for catalysts. However, the mechan...
- Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expression
[作者:Gomez-Casati, ME; Murtie, JC; Rio, C; Stankovic, K; Liberman, MC; Corfas, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17005-17010 , 文章类型: Article,,卷期:2010年107-39]
- Recent studies indicate that molecules released by glia can induce synapse formation. However, what induces glia to produce such signals, their identity, and their in vivo relevance remain poorly understood. Here we demo...
- Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons
[作者:Cao, JL; Vialou, VF; Lobo, MK; Robison, AJ; Neve, RL; Cooper, DC; Nestler, EJ; Han, MH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17011-17016 , 文章类型: Article,,卷期:2010年107-39]
- Excessive inhibition of brain neurons in primary or slice cultures can induce homeostatic intrinsic plasticity, but the functional role and underlying molecular mechanisms of such plasticity are poorly understood. Here, ...
- A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae
[作者:Baxter, RHG; Steinert, S; Chelliah, Y; Volohonsky, G; Levashina, EA; Deisenhofer, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16817-16822 , 文章类型: Article,,卷期:2010年107-39]
- The leucine-rich repeat (LRR) proteins LRIM1 and APL1C control the function of the complement-like protein TEP1 in Anopheles mosquitoes. The molecular structure of LRIM1 and APL1C and the basis of their interaction with ...
- Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria
[作者:Watt, IN; Montgomery, MG; Runswick, MJ; Leslie, AGW; Walker, JE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16823-16827 , 文章类型: Article,,卷期:2010年107-39]
- The catalytic domain of the F-ATPase in mitochondria protrudes into the matrix of the organelle, and is attached to the membrane domain by central and peripheral stalks. Energy for the synthesis of ATP from ADP and phosp...
- Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events
[作者:Liu, JY; Li, N; Yang, J; Li, N; Qiu, H; Ai, D; Chiamvimonvat, N; Zhu, Y; Hammock, BD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17017-17022 , 文章类型: Article,,卷期:2010年107-39]
- Chronic administration of high levels of selective COX-2 inhibitors (coxibs), particularly rofecoxib, valdecoxib, and parecoxib, increases risk for cardiovascular disease. Understanding the possibly multiple mechanisms u...
- Branchiostoma floridae has separate healing and sealing enzymes for 5 '-phosphate RNA ligation
[作者:Englert, M; Sheppard, K; Gundllapalli, S; Beier, H; Soll, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16834-16839 , 文章类型: Article,,卷期:2010年107-39]
- Animal cells have two tRNA splicing pathways: (i) a 5'-P ligation mechanism, where the 5'-phosphate of the 3' tRNA half becomes the junction phosphate of the new phosphodiester linkage, and (ii) a 3'-P ligation process, ...
- Vertebrate fatty acyl desaturase with Delta 4 activity
[作者:Li, YY; Monroig, O; Zhang, LA; Wang, SQ; Zheng, XZ; Dick, JR; You, CH; Tocher, DR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16840-16845 , 文章类型: Article,,卷期:2010年107-39]
- Biosynthesis of the highly biologically active long-chain polyunsaturated fatty acids, arachidonic (ARA), eicosapentaenoic (EPA), and docosahexaenoic (DHA) acids, in vertebrates requires the introduction of up to three d...
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