- Acetylation modulates prolactin receptor dimerization
[作者:Ma, L; Gao, JS; Guan, YJ; Shi, XY; Zhang, H; Ayrapetov, MK; Zhang, Z; Xu, L; Hyun, YM; Kim, M; Zhuang, SG; Chin, YE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19314-19319 , 文章类型: Article,,卷期:2010年107-45]
- Cytokine-activated receptors undergo extracellular domain dimerization, which is necessary to activate intracellular signaling pathways. Here, we report that in prolactin (PRL)-treated cells, PRL receptor (PRLR) undergoe...
- DDS, 4,4 '-diaminodiphenylsulfone, extends organismic lifespan
[作者:Cho, SC; Park, MC; Keam, B; Choi, JM; Cho, Y; Hyun, S; Park, SC; Lee, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19326-19331 , 文章类型: Article,,卷期:2010年107-45]
- DDS, 4,4'-diaminodiphenylsulfone, is the most common drug prescribed to treat Hansen disease patients. In addition to its antibacterial activity, DDS has been reported to be involved in other cellular processes that occu...
- Duration of estrogen deprivation, not chronological age, prevents estrogen's ability to enhance hippocampal synaptic physiology
[作者:Smith, CC; Vedder, LC; Nelson, AR; Bredemann, TM; McMahon, LL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19543-19548 , 文章类型: Article,,卷期:2010年107-45]
- Whether estrogen replacement is beneficial to cognitive health is controversial. Some studies have shown that estrogen replacement therapy (ERT) relieves memory impairment associated with menopause in women, whereas othe...
- Rubicon controls endosome maturation as a Rab7 effector
[作者:Sun, QM; Westphal, W; Wong, KN; Tan, I; Zhong, Q,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19338-19343 , 文章类型: Article,,卷期:2010年107-45]
- The activation and recruitment of the small GTPase Rab7 to early endosome is a critical step for early to late endosome maturation, a process that requires the class III phosphatidylinositol 3-kinase (PI3KC3) and GTPase ...
- Xenopus furry contributes to release of microRNA gene silencing
[作者:Goto, T; Fukui, A; Shibuya, H; Keller, R; Asashima, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19344-19349 , 文章类型: Article,,卷期:2010年107-45]
- A transcriptional corepressor, Xenopus furry (Xfurry), is expressed in the chordamesodermal region and induces secondary dorsal axes when overexpressed on the ventral side of the embryo. The N-terminal furry domain funct...
- Spectral quality of light modulates emotional brain responses in humans
[作者:Vandewalle, G; Schwartz, S; Grandjean, D; Wuillaume, C; Balteau, E; Degueldre, C; Schabus, M; Phillips, C; Luxen, A; Dijk, DJ; Maquet, P,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19549-19554 , 文章类型: Article,,卷期:2010年107-45]
- Light therapy can be an effective treatment for mood disorders, suggesting that light is able to affect mood state in the long term. As a first step to understand this effect, we hypothesized that light might also acutel...
- Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis
[作者:Abad, C; Tan, YV; Lopez, R; Nobuta, H; Dong, HM; Phan, P; Feng, JM; Campagnoni, AT; Waschek, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19555-19560 , 文章类型: Article,,卷期:2010年107-45]
- The neuropeptide vasoactive intestinal peptide (VIP) has been shown to inhibit macrophage proinflammatory actions, promote a positive Th2/Th1 balance, and stimulate regulatory T-cell production. The fact that this peptid...
- Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins
[作者:Bard, L; Sainlos, M; Bouchet, D; Cousins, S; Mikasova, L; Breillat, C; Stephenson, FA; Imperiali, B; Choquet, D; Groc, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19561-19566 , 文章类型: Article,,卷期:2010年107-45]
- The relative content of NR2 subunits in the NMDA receptor confers specific signaling properties and plasticity to synapses. However, the mechanisms that dynamically govern the retention of synaptic NMDARs, in particular ...
- brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis
[作者:Shive, HR; West, RR; Embree, LJ; Azuma, M; Sood, R; Liu, P; Hickstein, DD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19350-19355 , 文章类型: Article,,卷期:2010年107-45]
- Humans with inherited mutations in BRCA2 are at increased risk for developing breast and ovarian cancer; however, the relationship between BRCA2 mutation and these cancers is not understood. Studies of Brca2 mutation by ...
- An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation
[作者:Nadeau, M; Georges, RO; Laforest, B; Yamak, A; Lefebvre, C; Beauregard, J; Paradis, P; Bruneau, BG; Andelfinger, G; Nemer, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19356-19361 , 文章类型: Article,,卷期:2010年107-45]
- In humans, septal defects are among the most prevalent congenital heart diseases, but their cellular and molecular origins are not fully understood. We report that transcription factor Tbx5 is present in a subpopulation ...
- Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system
[作者:Kallupi, M; Cannella, N; Economidou, D; Ubaldi, M; Ruggeri, B; Weiss, F; Massi, M; Marugan, J; Heilig, M; Bonnavion, P; de Lecea, L; Ciccocioppo, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19567-19572 , 文章类型: Article,,卷期:2010年107-45]
- Drug addiction is a chronic relapsing disorder characterized by compulsive drug seeking and use. Environmental conditioning factors are among the major determinants of relapse in abstinent cocaine users. Here we describe...
- alpha beta gamma-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
[作者:Greten-Harrison, B; Polydoro, M; Morimoto-Tomita, M; Diao, L; Williams, AM; Nie, EH; Makani, S; Tian, N; Castillo, PE; Buchman, VL; Chandra, SS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19573-19578 , 文章类型: Article,,卷期:2010年107-45]
- Synucleins are a vertebrate-specific family of abundant neuronal proteins. They comprise three closely related members, alpha-, beta-, and gamma-synuclein. alpha-Synuclein has been the focus of intense attention since mu...
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