- Radiometric dating of the type-site for Homo heidelbergensis at Mauer, Germany
[作者:Wagner, GA; Krbetschek, M; Degering, D; Bahain, JJ; Shao, QF; Falgueres, C; Voinchet, P; Dolo, JM; Garcia, T; Rightmire, GP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19726-19730 , 文章类型: Article,,卷期:2010年107-46]
- The Mauer mandible, holotype of Homo heidelbergensis, was found in 1907 in fluvial sands deposited by the Neckar River 10 km southeast of Heidelberg, Germany. The fossil is an important key to understanding early human o...
- Evolution of the mammalian embryonic pluripotency gene regulatory network
[作者:Fernandez-Tresguerres, B; Canon, S; Rayon, T; Pernaute, B; Crespo, M; Torroja, C; Manzanares, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19955-19960 , 文章类型: Article,,卷期:2010年107-46]
- Embryonic pluripotency in the mouse is established and maintained by a gene-regulatory network under the control of a core set of transcription factors that include octamer-binding protein 4 (Oct4; official name POU doma...
- Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
[作者:Nguyen, NT; Kimura, A; Nakahama, T; Chinen, I; Masuda, K; Nohara, K; Fujii-Kuriyama, Y; Kishimoto, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19961-19966 , 文章类型: Article,,卷期:2010年107-46]
- Although an immunoregulatory role of aryl hydrocarbon receptor (Ahr) has been demonstrated in T cells and macrophages, little is known about its function in dendritic cells (DC). Here, we show that lipopolysaccharide (LP...
- Stepwise loading of yeast clamp revealed by ensemble and single-molecule studies
[作者:Kumar, R; Nashine, VC; Mishra, PP; Benkovic, SJ; Lee, TH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19736-19741 , 文章类型: Article,,卷期:2010年107-46]
- In ensemble and single-molecule experiments using the yeast proliferating cell nuclear antigen (PCNA, clamp) and replication factor C (RFC, clamp loader), we have examined the assembly of the RFC . PCNA . DNA complex and...
- MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
[作者:Brandl, K; Sun, L; Neppl, C; Siggs, OM; Le Gall, SM; Tomisato, W; Li, XH; Du, X; Maennel, DN; Blobel, CP; Beutler, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19967-19972 , 文章类型: Article,,卷期:2010年107-46]
- Toll-like receptors (TLRs) trigger intestinal inflammation when the epithelial barrier is breached by physical trauma or pathogenic microbes. Although it has been shown that TLR-mediated signals are ultimately protective...
- Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
[作者:Blasius, AL; Arnold, CN; Georgel, P; Rutschmann, S; Xia, Y; Lin, P; Ross, C; Li, XH; Smart, NG; Beutler, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19973-19978 , 文章类型: Article,,卷期:2010年107-46]
- Despite their low frequency, plasmacytoid dendritic cells (pDCs) produce most of the type I IFN that is detectable in the blood following viral infection. The endosomal Toll-like receptors (TLRs) TLR7 and TLR9 are requir...
- Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation
[作者:Ishikawa, E; Miyake, Y; Hara, H; Saito, T; Yamasaki, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19979-19984 , 文章类型: Article,,卷期:2010年107-46]
- The pre-T-cell receptor (TCR) is crucial for the early T-cell development, but the ligand for pre-TCR remains unidentified. We recently proposed a model that pre-TCR complexes oligomerize spontaneously through interactio...
- Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-angstrom resolution
[作者:Armache, JP; Jarasch, A; Anger, AM; Villa, E; Becker, T; Bhushan, S; Jossinet, F; Habeck, M; Dindar, G; Franckenberg, S; Marquez, V; Mielke, T; Thomm, M; Berninghausen, O; Beatrix, B; Soding, J; Westhof, E; Wilson, DN; Beckmann, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19748-19753 , 文章类型: Article,,卷期:2010年107-46]
- Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structu...
- Localization of eukaryote-specific ribosomal proteins in a 5.5-angstrom cryo-EM map of the 80S eukaryotic ribosome
[作者:Armache, JP; Jarasch, A; Anger, AM; Villa, E; Becker, T; Bhushan, S; Jossinet, F; Habeck, M; Dindar, G; Franckenberg, S; Marquez, V; Mielke, T; Thomm, M; Berninghausen, O; Beatrix, B; Soding, J; Westhof, E; Wilson, DN; Beckmann, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19754-19759 , 文章类型: Article,,卷期:2010年107-46]
- Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial coun...
- Mechanism of 2-oxoglutarate signaling by the Synechococcus elongatus P-II signal transduction protein
[作者:Fokina, O; Chellamuthu, VR; Forchhammer, K; Zeth, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19760-19765 , 文章类型: Article,,卷期:2010年107-46]
P-II proteins control key processes of nitrogen metabolism in bacteria, archaea, and plants in response to the central metabolites ATP, ADP, and 2-oxoglutarate (2-OG), signaling cellular energy and carbon and nitrogen...
- Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
[作者:Mallery, DL; McEwan, WA; Bidgood, SR; Towers, GJ; Johnson, CM; James, LC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19985-19990 , 文章类型: Article,,卷期:2010年107-46]
- Antibodies provide effective antiviral immunity despite the fact that viruses escape into cells when they infect. Here we show that antibodies remain attached to viruses after cell infection and mediate an intracellular ...
- Identification of the pre-T-cell receptor a chain in nonmammalian vertebrates challenges the structure-function of the molecule
[作者:Smelty, P; Marchal, C; Renard, R; Sinzelle, L; Pollet, N; Dunon, D; Jaffredo, T; Sire, JY; Fellah, JS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19991-19996 , 文章类型: Article,,卷期:2010年107-46]
- In humans and mice, the early development of alpha beta T cells is controlled by the pre-T-cell receptor a chain (pT alpha) that is covalently associated with the T-cell receptor beta (TCR beta) chain to form the pre-T-c...
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