- Mutations in GNA11 in Uveal Melanoma
[作者:Van Raamsdonk, CD; Griewank, KG; Crosby, MB; Garrido, MC; Vemula, S; Wiesner, T; Obenauf, AC; Wackernagel, W; Green, G; Bouvier, N; Sozen, MM; Baimukanova, G; Roy, R; Heguy, A; Dolgalev, I; Khanin, R; Busam, K; Speicher, MR; O'Brien, J; Bastian, BC,期刊:New England Journal of Medicine, 页码:2191-2199 , 文章类型: Article,,卷期:2010年363-23]
- Background: Uveal melanoma is the most common intraocular cancer. There are no effective therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of heterotrimeric G proteins, are found in ...
- Adjuvant Docetaxel for High-Risk, Node-Negative Breast Cancer
[作者:Martin, M; Segui, MA; Anton, A; Ruiz, A; Ramos, M; Adrover, E; Aranda, I; Rodriguez-Lescure, A; Grosse, R; Calvo, L; Barnadas, A; Isla, D; del Prado, PM; Borrego, M; Zaluski, J; Arcusa, A; Munoz, M; Vega, JM; Mel, JR; Munarriz, B; Llorca, C; Jara, C; Alba, E; Florian, J; Li, JF; Garcia-Asenjo, JA; Saez, A; Rios, M; Almenar, S; Peiro, G; Lluch, A,期刊:New England Journal of Medicine, 页码:2200-2210 , 文章类型: Article,,卷期:2010年363-23]
- Background: A regimen of docetaxel, doxorubicin, and cyclophosphamide (TAC) is superior to a regimen of fluorouracil, doxorubicin, and cyclophosphamide (FAC) when used as adjuvant therapy in women with node-positive brea...
- Body-Mass Index and Mortality among 146 Million White Adults
[作者:de Gonzalez, AB; Hartge, P; Cerhan, JR; Flint, AJ; Hannan, L; MacInnis, RJ; Moore, SC; Tobias, GS; Anton-Culver, H; Freeman, LB; Beeson, WL; Clipp, SL; English, DR; Folsom, AR; Freedman, DM; Giles, G; Hakansson, N; Henderson, KD; Hoffman-Bolton, J; Hoppin, JA; Koenig, KL; Lee, IM; Linet, MS; Park, Y; Pocobelli, G; Schatzkin, A; Sesso, HD; Weiderpass, E; Willcox, BJ; Wolk, A; Zeleniuch-Jacquotte, A; Willett, WC; Thun, MJ,期刊:New England Journal of Medicine, 页码:2211-2219 , 文章类型: Article,,卷期:2010年363-23]
- Background: A high body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) is associated with increased mortality from cardiovascular disease and certain cancers, but the precise rela...
- Exome Sequencing, ANGPTL3 Mutations, and Familial Combined Hypolipidemia
[作者:Musunuru, K; Pirruccello, JP; Do, R; Peloso, GM; Guiducci, C; Sougnez, C; Garimella, KV; Fisher, S; Abreu, J; Barry, AJ; Fennell, T; Banks, E; Ambrogio, L; Cibulskis, K; Kernytsky, A; Gonzalez, E; Rudzicz, N; Engert, JC; DePristo, MA; Daly, MJ; Cohen, JC; Hobbs, HH; Altshuler, D; Schonfeld, G; Gabriel, SB; Yue, P; Kathiresan, S,期刊:New England Journal of Medicine, 页码:2220-2227 , 文章类型: Article,,卷期:2010年363-23]
- We sequenced all protein-coding regions of the genome (the "exome") in two family members with combined hypolipidemia, marked by extremely low plasma levels of low-density lipoprotein (LDL) cholesterol, high-density lipo...
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