- MoDEL (Molecular Dynamics Extended Library): A Database of Atomistic Molecular Dynamics Trajectories
[作者:Meyer, T; D'Abramo, M; Hospital, A; Rueda, M; Ferrer-Costa, C; Perez, A; Carrillo, O; Camps, J; Fenollosa, C; Repchevsky, D; Gelpi, JL; Orozco, M,期刊:Structure, 页码:1399-1409 , 文章类型: Article,,卷期:2010年18-11]
- More than 1700 trajectories of proteins representative of monomeric soluble structures in the protein data bank (PDB) have been obtained by means of state-of-the-art atomistic molecular dynamics simulations in near-physi...
- Engagement of Arginine Finger to ATP Triggers Large Conformational Changes in NtrC1 AAA+ ATPase for Remodeling Bacterial RNA Polymerase
[作者:Chen, BY; Sysoeva, TA; Chowdhury, S; Guo, LA; De Carlo, S; Hanson, JA; Yang, H; Nixon, BT,期刊:Structure, 页码:1420-1430 , 文章类型: Article,,卷期:2010年18-11]
- The NtrC-like AAA+ ATPases control virulence and other important bacterial activities through delivering mechanical work to sigma 54-RNA polymerase to activate transcription from sigma 54-dependent genes. We report the f...
- XLF Regulates Filament Architecture of the XRCC4.Ligase IV Complex
[作者:Hammel, M; Yu, YP; Fang, SJ; Lees-Miller, SP; Tainer, JA,期刊:Structure, 页码:1431-1442 , 文章类型: Article,,卷期:2010年18-11]
- DNA ligase IV (LigIV) is critical for non homologous end joining (NHEJ), the major DNA double-strand break (DSB) repair pathway in human cells, and LigIV activity is regulated by XRCC4 and XLF (XRCC4-like factor) interac...
- Formation of Salt Bridges Mediates Internal Dimerization of Myosin VI Medial Tail Domain
[作者:Kim, H; Hsin, J; Liu, YX; Selvin, PR; Schulten, K,期刊:Structure, 页码:1443-1449 , 文章类型: Article,,卷期:2010年18-11]
- The unconventional motor protein, myosin VI, is known to dimerize upon cargo binding to its C-terminal end. It has been shown that one of its tail domains, called the medial tail domain, is a dimerization region. The dom...
- Structure of a SLC26 Anion Transporter STAS Domain in Complex with Acyl Carrier Protein: Implications for E. coli YchM in Fatty Acid Metabolism
[作者:Babu, M; Greenblatt, JF; Emili, A; Strynadka, NCJ; Reithmeier, RAF; Moraes, TF,期刊:Structure, 页码:1450-1462 , 文章类型: Article,,卷期:2010年18-11]
- Escherichia coil YchM is a member of the SLC26 (SuIP) family of anion transporters with an N-terminal membrane domain and a C-terminal cytoplasmic STAS domain. Mutations in human members of the SLC26 family, including th...
- Structural Basis for Error-free Replication of Oxidatively Damaged DNA by Yeast DNA Polymerase eta
[作者:Silverstein, TD; Jain, R; Johnson, RE; Prakash, L; Prakash, S; Aggarwal, AK,期刊:Structure, 页码:1463-1470 , 文章类型: Article,,卷期:2010年18-11]
- 7,8-dihydro-8-oxoguanine (8-oxoG) adducts are formed frequently by the attack of oxygen-free radicals on DNA. They are among the most mutagenic lesions in cells because of their dual coding potential, where, in addition ...
- Structure of Yeast Regulatory Subunit: A Glimpse into the Evolution of PKA Signaling
[作者:Rinaldi, J; Wu, JA; Yang, J; Ralston, CY; Sankaran, B; Moreno, S; Taylor, SS,期刊:Structure, 页码:1471-1482 , 文章类型: Article,,卷期:2010年18-11]
- The major cAMP receptors in eukaryotes are the regulatory (R) subunits of PKA, an allosteric enzyme conserved in fungi through mammals. While mammals have four R-subunit genes, Saccharomyces cerevisiae has only one, Bcy1...
- Hydrogen/Deuterium Exchange Analysis of HIV-1 Capsid Assembly and Maturation
[作者:Monroe, EB; Kang, S; Kyere, SK; Li, R; Prevelige, PE,期刊:Structure, 页码:1483-1491 , 文章类型: Article,,卷期:2010年18-11]
- Following budding, HIV-1 virions undergo a maturation process where the Gag polyprotein in the immature virus is cleaved by the viral protease and rearranges to form the mature infectious virion. Despite the wealth of st...
- Phosphorylation of DCC by ERK2 Is Facilitated by Direct Docking of the Receptor P1 Domain to the Kinase
[作者:Ma, WF; Shang, YA; Wei, ZY; Wen, WY; Wang, WN; Zhang, MJ,期刊:Structure, 页码:1502-1511 , 文章类型: Article,,卷期:2010年18-11]
- Netrin receptor DCC plays critical roles in many cellular processes, including axonal outgrowth and migration, angiogenesis, and apoptosis, but the molecular basis of DCC-mediated signaling is largely unclear. ERK2, a me...
- Structural Underpinnings of Nitrogen Regulation by the Prototypical Nitrogen-Responsive Transcriptional Factor NrpR
[作者:Wisedchaisri, G; Dranow, DM; Lie, TJ; Bonanno, JB; Patskovsky, Y; Ozyurt, SA; Sauder, JM; Almo, SC; Wasserman, SR; Burley, SK; Leigh, JA; Gonen, T,期刊:Structure, 页码:1512-1521 , 文章类型: Article,,卷期:2010年18-11]
- Plants and microorganisms reduce environmental inorganic nitrogen to ammonium, which then enters various metabolic pathways solely via conversion of 2-oxoglutarate (2OG) to glutamate and glutamine. Cellular 2OG concentra...
- Crystallographic and Functional Analysis of the ESCRT-I/HIV-1 Gag PTAP Interaction
[作者:Im, YJ; Kuo, L; Ren, XF; Burgos, PV; Zhao, XZ; Liu, F; Burke, TR; Bonifacino, JS; Freed, EO; Hurley, JH,期刊:Structure, 页码:1536-1547 , 文章类型: Article,,卷期:2010年18-11]
- Budding of HIV-1 requires the binding of the PTAP late domain of the Gag p6 protein to the UEV domain of the TSG101 subunit of ESCRT-I. The normal function of this motif in cells is in receptor downregulation. Here, we r...
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