- Cripto-1 Is a Cell Surface Marker for a Tumorigenic, Undifferentiated Subpopulation in Human Embryonal Carcinoma Cells
[作者:Watanabe, K; Meyer, MJ; Strizzi, L; Lee, JM; Gonzales, M; Bianco, C; Nagaoka, T; Farid, SS; Margaryan, N; Hendrix, MJC; Vonderhaar, BK; Salomon, DS,期刊:Stem Cells, 页码:1303-1314 , 文章类型: Article,,卷期:2010年28-8]
- Deregulation of stem cells is associated with the generation and progression of malignant tumors. In addition, genes that are associated with early embryogenesis are frequently expressed in cancer. Cripto-1 (CR-1), a gly...
- E-Cadherin-Mediated Cell-Cell Contact Is Critical for Induced Pluripotent Stem Cell Generation
[作者:Chen, TT; Yuan, DT; Wei, B; Jiang, J; Kang, JH; Ling, K; Gu, YJ; Li, JS; Xiao, L; Pei, G,期刊:Stem Cells, 页码:1315-1325 , 文章类型: Article,,卷期:2010年28-8]
- The low efficiency of reprogramming and genomic integration of virus vectors obscure the potential application of induced pluripotent stem (iPS) cells; therefore, identification of chemicals and cooperative factors that ...
- A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease
[作者:Lonardo, E; Parish, CL; Ponticelli, S; Marasco, D; Ribeiro, D; Ruvo, M; De Falco, S; Arenas, E; Minchiotti, G,期刊:Stem Cells, 页码:1326-1337 , 文章类型: Article,,卷期:2010年28-8]
- Cripto is a glycosylphosphatidylinositol-anchored coreceptor that binds Nodal and the activin type I (ALK)-4 receptor, and is involved in cardiac differentiation of mouse embryonic stem cells (mESCs). Interestingly, gene...
- Inducible Gene and shRNA Expression in Resident Hematopoietic Stem Cells In Vivo
[作者:Laurenti, E; Barde, I; Verp, S; Offner, S; Wilson, A; Quenneville, S; Wiznerowicz, M; MacDonald, HR; Trono, D; Trumpp, A,期刊:Stem Cells, 页码:1390-1398 , 文章类型: Article,,卷期:2010年28-8]
- Hematopoietic stem cells (HSC) are probably the best understood somatic stem cells and often serve as a paradigm for other stem cells. Nevertheless, most current techniques to genetically manipulate them in vivo are eith...
- Characterization of drCol 15a1b: A Novel Component of the Stem Cell Niche in the Zebrafish Retina
[作者:Gonzalez-Nunez, V; Nocco, V; Budd, A,期刊:Stem Cells, 页码:1399-1411 , 文章类型: Article,,卷期:2010年28-8]
- There is a clear need to develop novel tools to help improve our understanding of stem cell biology, and potentially also the utility of stem cells in regenerative medicine. We report the cloning, functional, and bioinfo...
- Comparison of Reprogramming Efficiency Between Transduction of Reprogramming Factors, Cell-Cell Fusion, and Cytoplast Fusion
[作者:Hasegawa, K; Zhang, PL; Wei, Z; Pomeroy, JE; Lu, WG; Pera, MF,期刊:Stem Cells, 页码:1338-1348 , 文章类型: Article,,卷期:2010年28-8]
- Reprogramming human somatic cells into pluripotent cells opens up new possibilities for transplantation therapy, the study of disease, and drug screening. In addition to somatic cell nuclear transfer, several approaches ...
- Aberrant Epigenetic Silencing of Tumor Suppressor Genes Is Reversed by Direct Reprogramming
[作者:Ron-Bigger, S; Bar-Nur, O; Isaac, S; Bocker, M; Lyko, F; Eden, A,期刊:Stem Cells, 页码:1349-1354 , 文章类型: Article,,卷期:2010年28-8]
- Direct reprogramming procedures reset the epigenetic memory of cells and convert differentiated somatic cells into pluripotent stem cells. In addition to epigenetic memory of cell identity, which is established during de...
- Sin3a Is Required by Sertoli Cells to Establish a Niche for Undifferentiated Spermatogonia, Germ Cell Tumors, and Spermatid Elongation
[作者:Payne, CJ; Gallagher, SJ; Foreman, O; Dannenberg, JH; Depinho, RA; Braun, RE,期刊:Stem Cells, 页码:1424-1434 , 文章类型: Article,,卷期:2010年28-8]
- Microenvironments support the maintenance of stem cells and the growth of tumors through largely unknown mechanisms. While cell-autonomous chromatin modifications have emerged as important determinants for self-renewal a...
- ATP-Sensitive K+ Channel-Deficient Dilated Cardiomyopathy Proteome Remodeled by Embryonic Stem Cell Therapy
[作者:Zlatkovic-Lindor, J; Arrell, DK; Yamada, S; Nelson, TJ; Terzic, A,期刊:Stem Cells, 页码:1355-1367 , 文章类型: Article,,卷期:2010年28-8]
- Transplantation of pluripotent stem cells has proven beneficial in heart failure, yet the proteomic landscape underlying repair remains largely uncharacterized. In a genetic model of dilated cardiomyopathy elicited by pr...
- BMP Signaling in the Human Fetal Ovary is Developmentally Regulated and Promotes Primordial Germ Cell Apoptosis
[作者:Childs, AJ; Kinnell, HL; Collins, CS; Hogg, K; Bayne, RAL; Green, SJ; McNeilly, AS; Anderson, RA,期刊:Stem Cells, 页码:1368-1378 , 文章类型: Article,,卷期:2010年28-8]
Primordial germ cells (PGCs) are the embryonic precursors of gametes in the adult organism, and their development, differentiation, and survival are regulated by a combination of growth factors collectively known as t...
- Epithelial-Mesenchymal Transition-Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells
[作者:Battula, VL; Evans, KW; Hollier, BG; Shi, Y; Marini, FC; Ayyanan, A; Wang, RY; Brisken, C; Guerra, R; Andreeff, M; Mani, SA,期刊:Stem Cells, 页码:1435-1445 , 文章类型: Article,,卷期:2010年28-8]
- The epithelial-to-mesenchymal transition (EMT) is an embryonic process that becomes latent in most normal adult tissues. Recently, we have shown that induction of EMT endows breast epithelial cells with stem cell traits....
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