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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共47条记录   Predicting Phospholipidosis Using Machine Learning [作者：Lowe, R; Glen, RC; Mitchell, JBO,期刊：Molecular Pharmaceutics, 页码：1708-1714 , 文章类型： Article，,卷期：2010年7-5] Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types. It is characterized by the excess accumulation of phospholipids and is most reliably identified by elect... Enhanced Generation of Cytotoxic T Lymphocytes by Heat Shock Protein 70 Fusion Proteins Harboring Both CD8(+) T Cell and CD4(+) T Cell Epitopes [作者：Takemoto, S; Nishikawa, M; Guan, X; Ohno, Y; Yata, T; Takakura, Y,期刊：Molecular Pharmaceutics, 页码：1715-1723 , 文章类型： Article，,卷期：2010年7-5] Heat shock protein 70 (Hsp70) can be a potent carrier of antigens because it is effectively delivered to antigen presenting cells (APCs) and activates innate immunity. To induce a potent cytotoxic T lymphocyte (CTL) resp... Nanoparticles Based on PLGA:Poloxamer Blends for the Delivery of Proangiogenic Growth Factors [作者：d'Angelo, I; Garcia-Fuentes, M; Parajo, Y; Welle, A; Vantus, T; Horvath, A; Bokonyi, G; Keri, G; Alonso, MJ,期刊：Molecular Pharmaceutics, 页码：1724-1733 , 文章类型： Article，,卷期：2010年7-5] New blood vessel formation is a critical requirement for treating many vascular and ischemia related diseases, as well as for many tissue engineering applications. Angiogenesis and vasculogenesis, in fact, represent cruc... Effects of PEGylation and Acetylation of PAMAM Dendrimers on DNA Binding, Cytotoxicity and in Vitro Transfection Efficiency [作者：Fant, K; Eshjorner, EK; Jenkins, A; Grossel, MC; Lincoln, P; Norden, B,期刊：Molecular Pharmaceutics, 页码：1734-1746 , 文章类型： Article，,卷期：2010年7-5] Poly(amidoamine) (PAMAM) dendrimers are promising multipotent gene delivery vectors, providing favorable DNA condensation properties also in combination with the possibility of conjugation of different targeting ligands ... Intestinal Absorption Mechanism of Tebipenem Pivoxil, a Novel Oral Carbapenem: Involvement of Human OATP Family in Apical Membrane Transport [作者：Kato, K; Shirasaka, Y; Kuraoka, E; Kikuchi, A; Iguchi, M; Suzuki, H; Shibasaki, S; Kurosawa, T; Tamai, I,期刊：Molecular Pharmaceutics, 页码：1747-1756 , 文章类型： Article，,卷期：2010年7-5] Tebipenem pivoxil (TBPM-PI) is an oral carbapenem antibiotic for treating otolaryngologic and respiratory infections in pediatric patients. This agent is a prodrug to improve intestinal absorption of TBPM, an active form... Interaction of Poly(glycoamidoamine) DNA Delivery Vehicles with Cell-Surface Glycosaminoglycans Leads to Polyplex Internalization in a Manner Not Solely Dependent on Charge [作者：McLendon, PM; Buckwalter, DJ; Davis, EM; Reineke, TM,期刊：Molecular Pharmaceutics, 页码：1757-1768 , 文章类型： Article，,卷期：2010年7-5] Understanding the mechanisms of cellular internalization is necessary for rational design of efficient polymers for DNA delivery. In this paper, we present evidence that poly(glycoamidoamine) (PGAA) DNA complexes (polypl... Crystallization of Amorphous Indomethacin during Dissolution: Effect of Processing and Annealing [作者：Greco, K; Bogner, R,期刊：Molecular Pharmaceutics, 页码：1406-1418 , 文章类型： Article，,卷期：2010年7-5] The crystallization of amorphous drugs during dissolution is a type of solution mediated phase transformation that can reduce the bioavailability enhancement one hoped to gain from the amorphous state. The goal of this s... Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media [作者：Fagerberg, JH; Tsinman, O; Sun, N; Tsinman, K; Avdeef, A; Bergstrom, CAS,期刊：Molecular Pharmaceutics, 页码：1419-1430 , 文章类型： Article，,卷期：2010年7-5] A series of poorly soluble BCS class II compounds with "grease ball" characteristics were assessed for solubility and dissolution rate in biorelevant dissolution media (BDM) with the purpose of investigating which molecu... Cytokine Binding by Polysaccharide-Antibody Conjugates [作者：Sun, LAT; Buchholz, KS; Lotze, MT; Washburn, NR,期刊：Molecular Pharmaceutics, 页码：1769-1777 , 文章类型： Article，,卷期：2010年7-5] Cytokine-neutralizing antibodies are used in treating a broad range of inflammatory conditions. We demonstrate that monoclonal antibodies against interleukin-1 beta and tumor necrosis factor-a were still active when conj... Combined Chemo-immunotherapy as a Prospective Strategy To Combat Cancer: A Nanoparticle Based Approach [作者：Roy, A; Singh, MS; Upadhyay, P; Bhaskar, S,期刊：Molecular Pharmaceutics, 页码：1778-1788 , 文章类型： Article，,卷期：2010年7-5] The prime objective of this study was to develop a combined chemo-immunotherapeutic formulation which could directly kill cancer cells as well as activate the immunosuppressed tumor microenvironment to mount a robust ant... Quantitative Analysis of the Effect of Supersaturation on in Vivo Drug Absorption [作者：Takano, R; Takata, N; Saito, R; Furumoto, K; Higo, S; Hayashi, Y; Machida, M; Aso, Y; Yamashita, S,期刊：Molecular Pharmaceutics, 页码：1431-1440 , 文章类型： Article，,卷期：2010年7-5] The purpose of this study is to clarify the effects of intestinal drug supersaturation on solubility-limited nonlinear absorption. Oral absorption of a novel farnesyltransferase inhibitor (FTI-2600) from its crystalline ... Modifying the Diffusion Layer of Soluble Salts of Poorly Soluble Basic Drugs To Improve Dissolution Performance [作者：Hawley, M; Morozowich, W,期刊：Molecular Pharmaceutics, 页码：1441-1449 , 文章类型： Article，,卷期：2010年7-5] The dissolution mechanism of soluble salts of poorly soluble bases can be complex because both the dissolution of the salt and precipitation of the free base can occur depending on the experimental conditions and propert... Substrate Affinity of Photosensitizers Derived from Chlorophyll-a: The ABCG2 Transporter Affects the Phototoxic Response of Side Population Stem Cell-like Cancer Cells to Photodynamic Therapy [作者：Morgan, J; Jackson, JD; Zheng, XA; Pandey, SK; Pandey, RK,期刊：Molecular Pharmaceutics, 页码：1789-1804 , 文章类型： Article，,卷期：2010年7-5] Photosensitizers (PS) synthesized with the aim of optimizing photodynamic therapy (PDT) of tumors do not always fulfill their potential when tested in vitro and in vivo in different tumor models. The ATP-dependent transp... Dissolution Modeling of Bead Formulations and Predictions of Bioequivalence for a Highly Soluble, Highly Permeable Drug [作者：Sperry, DC; Thomas, SJ; Lobo, E,期刊：Molecular Pharmaceutics, 页码：1450-1457 , 文章类型： Article，,卷期：2010年7-5] The objective of this study was to assess the impact of observed in vitro dissolution rate differences on in vivo pharmacokinetics for two enteric-coated bead formulations of a highly soluble, highly permeable drug. A ne... Application of a Biphasic Test for Characterization of In Vitro Drug Release of Immediate Release Formulations of Celecoxib and Its Relevance to In Vivo Absorption [作者：Shi, Y; Gao, P; Gong, YC; Ping, HL,期刊：Molecular Pharmaceutics, 页码：1458-1465 , 文章类型： Article，,卷期：2010年7-5] A biphasic in vitro test method was used to examine release profiles of a poorly soluble model drug, celecoxib (CEB), from its immediate release formulations. Three formulations of CEB were investigated in this study, in... Validation of In Vitro Cell-Based Human Blood Brain Barrier Model Using Clinical Positron Emission Tomography Radioligands To Predict In Vivo Human Brain Penetration [作者：Mabondzo, A; Bottlaender, M; Guyot, AC; Tsaouin, K; Deverre, JR; Balimane, PV,期刊：Molecular Pharmaceutics, 页码：1805-1815 , 文章类型： Article，,卷期：2010年7-5] We have evaluated a novel in vitro cell-based human blood brain barrier (BBB) model that could predict in vivo human brain penetration for compounds with different BBB permeabilities using the clinical positron emission ...