- Conformational Switching of the Diphtheria Toxin T Domain
[作者:Rodnin, MV; Kyrychenko, A; Kienker, P; Sharma, O; Posokhov, YO; Collier, RJ; Finkelstein, A; Ladokhin, AS,期刊:Journal of Molecular Biology, 页码:1-7 , 文章类型: Article,,卷期:2010年402-1]
- The diphtheria toxin T domain translocates the catalytic C domain across the endosomal membrane in response to acidification. To elucidate the role of histidine protonation in modulating pH-dependent membrane action of t...
- Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b
[作者:Garcia, BL; Ramyar, KX; Tzekou, A; Ricklin, D; McWhorter, WJ; Lambris, JD; Geisbrecht, BV,期刊:Journal of Molecular Biology, 页码:17-29 , 文章类型: Article,,卷期:2010年402-1]
- The human complement system plays an essential role in innate and adaptive immunity by marking and eliminating microbial intruders. Activation of complement on foreign surfaces results in proteolytic cleavage of compleme...
- Nebulin: A Study of Protein Repeat Evolution
[作者:Bjorklund, AK; Light, S; Sagit, R; Elofsson, A,期刊:Journal of Molecular Biology, 页码:38-51 , 文章类型: Article,,卷期:2010年402-1]
- Protein domain repeats are common in proteins that are central to the organization of a cell, in particular in eukaryotes. They are known to evolve through internal tandem duplications. However, the understanding of the ...
- Multiplexing RMCE: Versatile Extensions of the Flp-Recombinase-Mediated Cassette-Exchange Technology
[作者:Turan, S; Kuehle, J; Schambach, A; Baum, C; Bode, J,期刊:Journal of Molecular Biology, 页码:52-69 , 文章类型: Article,,卷期:2010年402-1]
- There are strong indications, but as yet no proof, that extended 48-bp Flp recombinase targets (FRTs) represent unique targets in all eukaryotic genomes investigated, and that recombinase-mediated cassette exchange is no...
- Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O-6-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage
[作者:Groth, P; Auslander, S; Majumder, MM; Schultz, N; Johansson, F; Petermann, E; Helleday, T,期刊:Journal of Molecular Biology, 页码:70-82 , 文章类型: Article,,卷期:2010年402-1]
- Even though DNA alkylating agents have been used for many decades in the treatment of cancer, it remains unclear what happens when replication forks encounter alkylated DNA. Here, we used the DNA fibre assay to study the...
- Molecular Basis for the Recognition of Phosphorylated STAT1 by Importin alpha 5
[作者:Nardozzi, J; Wenta, N; Yasuhara, N; Vinkemeier, U; Cingolani, G,期刊:Journal of Molecular Biology, 页码:83-100 , 文章类型: Article,,卷期:2010年402-1]
- Interferon-gamma stimulation triggers tyrosine phosphorylation of the transcription factor STAT1 at position 701, which is associated with switching from carrier-independent nucleocytoplasmic shuttling to carrier-mediate...
- The Role of the T7 Gp2 Inhibitor of Host RNA Polymerase in Phage Development
[作者:Savalia, D; Robins, W; Nechaev, S; Molineux, I; Severinov, K,期刊:Journal of Molecular Biology, 页码:118-126 , 文章类型: Article,,卷期:2010年402-1]
- Bacteriophage T7 relies on its own RNA polymerase (RNAp) to transcribe its middle and late genes. Early genes, which include the viral RNAp gene, are transcribed by the host RNAp from three closely spaced strong promoter...
- HIV Fusion Peptide Penetrates, Disorders, and Softens T-Cell Membrane Mimics
[作者:Tristram-Nagle, S; Chan, R; Kooijman, E; Uppamoochikkal, P; Qiang, W; Weliky, DP; Nagle, JF,期刊:Journal of Molecular Biology, 页码:139-153 , 文章类型: Article,,卷期:2010年402-1]
- This work investigates the interaction of N-terminal gp41 fusion peptide (FP) of human immunodeficiency virus type 1 (HIV-1) with model membranes in order to elucidate how FP leads to fusion of HIV and T-cell membranes. ...
- Use of RNA Tertiary Interaction Modules for the Crystallisation of the Spliceosomal snRNP Core Domain
[作者:Leung, AKW; Kambach, C; Kondo, Y; Kampmann, M; Jinek, M; Nagai, K,期刊:Journal of Molecular Biology, 页码:154-164 , 文章类型: Article,,卷期:2010年402-1]
- RNA is known to perform diverse roles in the cell, often as ribonucleoprotein (RNP) particles. While the crystal structure of these RNP particles could provide crucial insights into their functions, crystallographic work...
- Cooperative Binding of MgATP and MgADP in the Trimeric P-II Protein GlnK2 from Archaeoglobus fulgidus
[作者:Helfmann, S; Lu, W; Litz, C; Andrade, SLA,期刊:Journal of Molecular Biology, 页码:165-177 , 文章类型: Article,,卷期:2010年402-1]
- P-II-like proteins, such as GlnK, found in a wide variety of organisms from prokaryotes to plants constitute a family of cytoplasmic signaling proteins that play a central regulatory role in the assimilation of nitrogen ...
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