- The miR-15/107 Group of MicroRNA Genes: Evolutionary Biology, Cellular Functions, and Roles in Human Diseases
[作者:Finnerty, JR; Wang, WX; Hebert, SS; Wilfred, BR; Mao, GG; Nelson, PT,期刊:Journal of Molecular Biology, 页码:491-509 , 文章类型: Review,,卷期:2010年402-3]
- The miR-15/107 group of microRNA (miRNA) gene is increasingly appreciated to serve key functions in humans. These miRNAs regulate gene expression involved in cell division, metabolism, stress response, and angiogenesis i...
- Chloroplast Import Signals: The Length Requirement for Translocation In Vitro and In Vivo
[作者:Bionda, T; Tillmann, B; Simm, S; Beilstein, K; Ruprecht, M; Schleiff, E,期刊:Journal of Molecular Biology, 页码:510-523 , 文章类型: Article,,卷期:2010年402-3]
- Protein translocation of cytosolically synthesized proteins requires signals for both targeting of precursor proteins to the surface of the respective compartment and their transfer across its membrane. In contrast to si...
- Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases
[作者:Tchigvintsev, A; Xu, XH; Singer, A; Chang, C; Brown, G; Proudfoott, M; Cui, H; Flick, R; Anderson, WF; Joachimiak, A; Galperin, MY; Savchenko, A; Yakunin, AF,期刊:Journal of Molecular Biology, 页码:524-538 , 文章类型: Article,,卷期:2010年402-3]
- Cyclic diguanylate (or bis-(3'-5') cyclic dimeric guanosine monophosphate; c-di-GMP) is a ubiquitous second messenger that regulates diverse cellular functions, including motility, biofilm formation, cell cycle progressi...
- Crystal Structure of the Cyanobacterial Signal Transduction Protein P-II in Complex with PipX
[作者:Zhao, MX; Jiang, YL; Xu, BY; Chen, YX; Zhang, CC; Zhou, CZ,期刊:Journal of Molecular Biology, 页码:552-559 , 文章类型: Article,,卷期:2010年402-3]
P-II proteins are highly conserved signal transducers in bacteria, archaea, and plants. They have a large flexible loop (T-loop) that adopts different conformations after covalent modification or binding to different ...
- Structure of the AML1-ETO NHR3-KA(RII alpha) Complex and Its Contribution to AML1-ETO Activity
[作者:Corpora, T; Roudaia, L; Oo, ZM; Chen, W; Manuylova, E; Cai, XW; Chen, MJ; Cierpicki, T; Speck, NA; Bushweller, JH,期刊:Journal of Molecular Biology, 页码:560-577 , 文章类型: Article,,卷期:2010年402-3]
- AML1-ETO is the chimeric protein product of t(8;21) in acute myeloid leukemia. The ETO portion of the fusion protein includes the nervy homology region (NHR) 3 domain, which shares homology with A-kinase anchoring protei...
- H-Bonding and Positive Charge at the N(5)/O(4) Locus Are Critical for Covalent Flavin Attachment in Trametes Pyranose 2-Oxidase
[作者:Tan, TC; Pitsawong, W; Wongnate, T; Spadiut, O; Haltrich, D; Chaiyen, P; Divne, C,期刊:Journal of Molecular Biology, 页码:578-594 , 文章类型: Article,,卷期:2010年402-3]
- Flavoenzymes perform a wide range of redox reactions in nature, and a subclass of flavoenzymes carry covalently bound cofactor. The enzyme-flavin bond helps to increase the flavin's redox potential to facilitate substrat...
- Effects of Turn Stability and Side-Chain Hydrophobicity on the Folding of beta-Structures
[作者:Shao, QA; Wei, HY; Gao, YQ,期刊:Journal of Molecular Biology, 页码:595-609 , 文章类型: Article,,卷期:2010年402-3]
- Key elements of beta-structure folding include hydrophobic core collapse, turn formation, and assembly of backbone hydrogen bonds. In the present folding simulations of several beta-hairpins and beta-sheets (peptide 1, p...
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