- IL-2 Induces Conformational Changes in Its Preassembled Receptor Core, Which Then Migrates in Lipid Raft and Binds to the Cytoskeleton Meshwork
[作者：Pillet, AH; Lavergne, V; Pasquier, V; Gesbert, F; Theze, J; Rose, T,期刊：Journal of Molecular Biology, 页码：671-692 , 文章类型： Article，,卷期：2010年403-5]
- While interleukin (IL)-2 clearly initiates the sequential assembly of its soluble receptor fragments (sIL-2R) in vitro (with sIL-2R alpha first, sIL-2R beta second, and s gamma c last), the assembly mechanism of full-len...
- Tail-Mediated Collapse of HMGB1 Is Dynamic and Occurs via Differential Binding of the Acidic Tail to the A and B Domains
[作者：Stott, K; Watson, M; Howe, FS; Grossmann, JG; Thomas, JO,期刊：Journal of Molecular Biology, 页码：706-722 , 文章类型： Article，,卷期：2010年403-5]
- The architectural DNA-binding protein HMGB1 consists of two tandem HMG-box domains joined by a basic linker to a C-terminal acidic tall, which negatively regulates HMGB1 DNA interactions by binding intramolecularly to th...
- Dissecting the Microscopic Steps of the Cyclophilin A Enzymatic Cycle on the Biological HIV-1 Capsid Substrate by NMR
[作者：Bosco, DA; Eisenmesser, EZ; Clarkson, MW; Wolf-Watz, M; Labeikovsky, W; Millet, O; Kern, D,期刊：Journal of Molecular Biology, 页码：723-738 , 文章类型： Article，,卷期：2010年403-5]
- Peptidyl prolyl isomerases (PPIases) are emerging as key regulators of many diverse biological processes Elucidating the role of PPIase activity in vivo has been challenging because mutagenesis of active-site residues no...
- Refolding and Polymerization Pathways of Neuroserpin
[作者：Takehara, S; Zhang, JA; Yang, XY; Takahashi, N; Mikami, B; Onda, M,期刊：Journal of Molecular Biology, 页码：751-762 , 文章类型： Article，,卷期：2010年403-5]
- Neuroserpin is a member of the serpin superfamily, and its mutants are retained within the endoplasmic reticulum of neurons as ordered polymers m association with dementia It has been proposed that neuroserpin polymers a...
- The Structures and Physicochemical Properties of Organic Cofactors in Biocatalysis
[作者：Fischer, JD; Holliday, GL; Rahman, SA; Thornton, JM,期刊：Journal of Molecular Biology, 页码：803-824 , 文章类型： Article，,卷期：2010年403-5]
- Many crucial biochemical reactions in the cell require not only enzymes for catalysis but also organic cofactors or metal ions Here, we analyse the physicochemical properties, chemical structures and functions of organic...
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