- Unstructured Hydrophilic Sequences in Prokaryotic Proteomes Correlate with Dehydration Tolerance and Host Association
[作者:Krisko, A; Smole, Z; Debret, G; Nikolic, N; Redman, M,期刊:Journal of Molecular Biology, 页码:775-782 , 文章类型: Article,,卷期:2010年402-5]
- Water loss or desiccation is among the most life-threatening stresses. It leads to DNA double-strand breakage, protein aggregation, cell shrinkage, and low water activity precluding all biological functions. Yet, in all ...
- The Non-Core Regions of Human Lysozyme Amyloid Fibrils Influence Cytotoxicity
[作者:Mossuto, MF; Dhulesia, A; Devlin, G; Frare, E; Kumita, JR; de Laureto, PP; Dumoulin, M; Fontana, A; Dobson, CM; Salvatella, X,期刊:Journal of Molecular Biology, 页码:783-796 , 文章类型: Article,,卷期:2010年402-5]
- Identifying the cause of the cytotoxicity of species populated during amyloid formation is crucial to understand the molecular basis of protein deposition diseases. We have examined different types of aggregates formed b...
- Structural Basis for the Dual Recognition of IL-12 and IL-23 by Ustekinumab
[作者:Luo, JQ; Wu, SJ; Lacy, ER; Orlovsky, Y; Baker, A; Teplyakov, A; Obmolova, G; Heavner, GA; Richter, HT; Benson, J,期刊:Journal of Molecular Biology, 页码:797-812 , 文章类型: Article,,卷期:2010年402-5]
- Interleukin (IL)-12 and IL-23 are heterodimeric proinflammatory cytokines that share a common p40 subunit, paired with p35 and p19 subunits, respectively. They represent an attractive class of therapeutic targets for the...
- Further Insight into Substrate Recognition by USP7: Structural and Biochemical Analysis of the HdmX and Hdm2 Interactions with USP7
[作者:Sarkari, F; La Delfa, A; Arrowsmith, CH; Frappier, L; Sheng, Y; Saridakis, V,期刊:Journal of Molecular Biology, 页码:825-837 , 文章类型: Article,,卷期:2010年402-5]
- Ubiquitin-specific protease 7 (USP7) catalyzes the deubiquitination of several substrate proteins including p53 and Hdm2. We have previously shown that USP7, and more specifically its amino-terminal domain (USP7-NTD), in...
- Thermodynamic Characterization of ppGpp Binding to EF-G or 1F2 and of Initiator tRNA Binding to Free 1F2 in the Presence of GDP, GTP, or ppGpp
[作者:Mitkevich, VA; Ermakov, A; Kulikova, AA; Tankov, S; Shyp, V; Soosaar, A; Tenson, T; Makarov, AA; Ehrenberg, M; Hauryliuk, V,期刊:Journal of Molecular Biology, 页码:838-846 , 文章类型: Article,,卷期:2010年402-5]
- In addition to their natural substrates GDP and GTP, the bacterial translational GTPases initiation factor (IF) 2 and elongation factor G (EF-G) interact with the alarmone molecule guanosine tetraphosphate (ppGpp), which...
- DNA Minor Groove Induced Dimerization of Heterocyclic Cations: Compound Structure, Binding Affinity, and Specificity for a TTAA Site
[作者:Munde, M; Kumar, A; Nhili, R; Depauw, S; David-Cordonnier, MH; Ismail, MA; Stephens, CE; Farahat, AA; Batista-Parra, A; Boykin, DW; Wilson, WD,期刊:Journal of Molecular Biology, 页码:847-864 , 文章类型: Article,,卷期:2010年402-5]
- With the increasing number and variations of genome sequences available, control of gene expression with synthetic, cell-permeable molecules is within reach. The variety of sequence-specific binding agents is, however, s...
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