- Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking
[作者:Vidal, OM; Stec, W; Bausek, N; Smythe, E; Zeidler, MP,期刊:Journal of cell science, 页码:3457-3466 , 文章类型: Article,,卷期:2010年123-20]
- Appropriate regulation of signal transduction pathways is essential for normal development and is often disrupted in disease. Therefore, many regulatory mechanisms and feedback loops have evolved to ensure appropriate si...
- Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes
[作者:Franco, DL; Mainez, J; Vega, S; Sancho, P; Murillo, MM; de Frutos, CA; del Castillo, G; Lopez-Blau, C; Fabregat, I; Nieto, MA,期刊:Journal of cell science, 页码:3467-3477 , 文章类型: Article,,卷期:2010年123-20]
- Although TGF-beta suppresses early stages of tumour development, it later contributes to tumour progression when cells become resistant to its suppressive effects. In addition to circumventing TGF-beta-induced growth arr...
- Syt1p promotes activation of Arl1p at the late Golgi to recruit Imh1p
[作者:Chen, KY; Tsai, PC; Hsu, JW; Hsu, HC; Fang, CY; Chang, LC; Tsai, YT; Yu, CJ; Jee, FJS,期刊:Journal of cell science, 页码:3478-3489 , 文章类型: Article,,卷期:2010年123-20]
- In yeast, Arl3p recruits Arl1p GTPase to regulate Golgi function and structure. However, the molecular mechanism involved in regulating activation of Arl1p at the Golgi is unknown. Here, we show that Syt1p promoted activ...
- The rotation of cellulose synthase trajectories is microtubule dependent and influences the texture of epidermal cell walls in Arabidopsis hypocotyls
[作者:Chan, J; Crowell, E; Eder, M; Calder, G; Bunnewell, S; Findlay, K; Vernhettes, S; Hofte, H; Lloyd, C,期刊:Journal of cell science, 页码:3490-3495 , 文章类型: Article,,卷期:2010年123-20]
- Plant shoots have thick, polylamellate outer epidermal walls based on crossed layers of cellulose microfibrils, but the involvement of microtubules in such wall lamellation is unclear. Recently, using a long-term movie s...
- A role for the dynamin-like protein Vps1 during endocytosis in yeast
[作者:Smaczynska-de Rooij, II; Allwood, EG; Aghamohammadzadeh, S; Hettema, EH; Goldberg, MW; Ayscough, KR,期刊:Journal of cell science, 页码:3496-3506 , 文章类型: Article,,卷期:2010年123-20]
- Dynamins are a conserved family of proteins involved in membrane fusion and fission. Although mammalian dynamins are known to be involved in several membrane-trafficking events, the role of dynamin-1 in endocytosis is th...
- Stromal fibroblasts from the interface zone of human breast carcinomas induce an epithelial-mesenchymal transition-like state in breast cancer cells in vitro
[作者:Gao, MQ; Kim, BG; Kang, S; Choi, YP; Park, H; Kang, KS; Cho, NH,期刊:Journal of cell science, 页码:3507-3514 , 文章类型: Article,,卷期:2010年123-20]
- Fibroblasts were extracted from tissue in tumor burden zones, distal normal zones and interface zones between tumor and normal tissue of human breast carcinomas, and the corresponding fibroblasts were designated as cance...
- PtdIns(3,4,5)P-3 is a regulator of myosin-X localization and filopodia formation
[作者:Plantard, L; Arjonen, A; Lock, JG; Nurani, G; Ivaska, J; Stromblad, S,期刊:Journal of cell science, 页码:3525-3534 , 文章类型: Article,,卷期:2010年123-20]
- Phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P-3] is a key regulator of cell signaling that acts by recruiting proteins to the cell membrane, such as at the leading edge during cell migration. Here, we show t...
- Rac controls PIP5K localisation and PtdIns(4,5)P-2 synthesis, which modulates vinculin localisation and neurite dynamics
[作者:Halstead, JR; Savaskan, NE; van den Bout, I; Van Horck, F; Hajdo-Milasinovic, A; Snell, M; Keune, WJ; ten Klooster, JP; Hordijk, PL; Divecha, N,期刊:Journal of cell science, 页码:3535-3546 , 文章类型: Article,,卷期:2010年123-20]
- In N1E-115 cells, neurite retraction induced by neurite remodelling factors such as lysophosphatidic acid, sphingosine 1-phosphate and semaphorin 3A require the activity of phosphatidylinositol 4-phosphate 5-kinases (PIP...
- Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock
[作者:Lee, Y; Lee, J; Kwon, I; Nakajima, Y; Ohmiya, Y; Son, GH; Lee, KH; Kim, K,期刊:Journal of cell science, 页码:3547-3557 , 文章类型: Article,,卷期:2010年123-20]
- The transcription factor CLOCK-BMAL1 is a core component of the molecular clock machinery that drives circadian gene expression and physiology in mammals. Recently, we reported that this heterodimeric transcription facto...
- ATF3, an adaptive-response gene, enhances TGF beta signaling and cancer-initiating cell features in breast cancer cells
[作者:Yin, X; Wolford, CC; Chang, YS; McConoughey, SJ; Ramsey, SA; Aderem, A; Hai, T,期刊:Journal of cell science, 页码:3558-3565 , 文章类型: Article,,卷期:2010年123-20]
- The activating transcription factor 3 (ATF3) gene is induced by a variety of signals, including many of those encountered by cancer cells. We present evidence that ATF3 is induced by TGF beta in the MCF10CA1a breast canc...
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