- Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress
[作者:Hailemariam, K; Iwasaki, K; Huang, BW; Sakamoto, K; Tsuji, Y,期刊:Journal of cell science, 页码:3863-3871 , 文章类型: Article,,卷期:2010年123-22]
- ATF1 (activating transcription factor 1), a stimulus-induced CREB family transcription factor, plays important roles in cell survival and proliferation. Phosphorylation of ATF1 at Ser63 by PKA (cAMP-dependent protein kin...
- Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - role of TGF beta 1 levels and RhoA activity
[作者:Blumbach, K; Zweers, MC; Brunner, G; Peters, AS; Schmitz, M; Schulz, JN; Schild, A; Denton, CP; Sakai, T; Fassler, R; Krieg, T; Eckes, B,期刊:Journal of cell science, 页码:3872-3883 , 文章类型: Article,,卷期:2010年123-22]
- Wound healing crucially relies on the mechanical activity of fibroblasts responding to TGF beta 1 and to forces transmitted across focal adhesions. Integrin-linked kinase (ILK) is a central adapter recruited to integrin ...
- Dynamic instability of the intracellular pressure drives bleb-based motility
[作者:Maugis, B; Brugues, J; Nassoy, P; Guillen, N; Sens, P; Amblard, F,期刊:Journal of cell science, 页码:3884-3892 , 文章类型: Article,,卷期:2010年123-22]
- We have demonstrated that the two-and three-dimensional motility of the human pathogenic parasite Entamoeba histolytica (Eh) depends on sustained instability of the intracellular hydrostatic pressure. This instability dr...
- Specific phosphorylation of Ser458 of A-type lamins in LMNA-associated myopathy patients
[作者:Mitsuhashi, H; Hayashi, YK; Matsuda, C; Noguchi, S; Wakatsuki, S; Araki, T; Nishino, I,期刊:Journal of cell science, 页码:3893-3900 , 文章类型: Article,,卷期:2010年123-22]
- Mutations in LMNA, which encodes A-type nuclear lamins, cause various human diseases, including myopathy, cardiomyopathy, lipodystrophy and progeria syndrome. To date, little is known about how mutations in a single gene...
- Kinectin-mediated endoplasmic reticulum dynamics supports focal adhesion growth in the cellular lamella
[作者:Zhang, X; Tee, YH; Heng, JK; Zhu, YJ; Hu, XA; Margadant, F; Ballestrem, C; Bershadsky, A; Griffiths, G; Yu, H,期刊:Journal of cell science, 页码:3901-3912 , 文章类型: Article,,卷期:2010年123-22]
- Focal adhesions (FAs) control cell shape and motility, which are important processes that underlie a wide range of physiological functions. FA dynamics is regulated by cytoskeleton, motor proteins and small GTPases. Kine...
- ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site
[作者:Le Gall, SM; Maretzky, T; Issuree, PDA; Niu, XD; Reiss, K; Saftig, P; Khokha, R; Lundell, D; Blobel, CP,期刊:Journal of cell science, 页码:3913-3922 , 文章类型: Article,,卷期:2010年123-22]
- Protein ectodomain shedding is crucial for cell-cell interactions because it controls the bioavailability of soluble tumor necrosis factor-alpha (TNF alpha) and ligands of the epidermal growth factor (EGF) receptor, and ...
- Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation
[作者:Kelley, LC; Ammer, AG; Hayes, KE; Martin, KH; Machida, K; Jia, L; Mayer, BJ; Weed, SA,期刊:Journal of cell science, 页码:3923-3932 , 文章类型: Article,,卷期:2010年123-22]
- The proto-oncogene Src tyrosine kinase (Src) is overexpressed in human cancers and is currently a target of anti-invasive therapies. Activation of Src is an essential catalyst of invadopodia production. Invadopodia are c...
- Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast
[作者:Zhai, YL; Yung, PYK; Huo, L; Liang, C,期刊:Journal of cell science, 页码:3933-3943 , 文章类型: Article,,卷期:2010年123-22]
- In eukaryotes, replication licensing is achieved through sequential loading of several replication-initiation proteins onto replication origins to form pre-replicative complexes (pre-RCs), and unscheduled replication lic...
- Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction
[作者:Bolliger, MF; Zurlinden, A; Luscher, D; Butikofer, L; Shakhova, O; Francolini, M; Kozlov, SV; Cinelli, P; Stephan, A; Kistler, AD; Rulicke, T; Pelczar, P; Ledermann, B; Fumagalli, G; Gloor, SM; Kunz, B; Sonderegger, P,期刊:Journal of cell science, 页码:3944-3955 , 文章类型: Article,,卷期:2010年123-22]
- During the initial stage of neuromuscular junction (NMJ) formation, nerve-derived agrin cooperates with muscle-autonomous mechanisms in the organization and stabilization of a plaque-like postsynaptic specialization at t...
- The AP-1 family member FOS blocks transcriptional activity of the nuclear receptor steroidogenic factor 1
[作者:Sirianni, R; Nogueira, E; Bassett, MH; Carr, BR; Suzuki, T; Pezzi, V; Ando, S; Rainey, WE,期刊:Journal of cell science, 页码:3956-3965 , 文章类型: Article,,卷期:2010年123-22]
- Steroid production in the adrenal zona glomerulosa is under the control of angiotensin II (Ang II), which, upon binding to its receptor, activates protein kinase C (PKC) within these cells. PKC is a potent inhibitor of t...
- The AP-1 clathrin adaptor facilitates cilium formation and functions with RAB-8 in C. elegans ciliary membrane transport
[作者:Kaplan, OI; Molla-Herman, A; Cevik, S; Ghossoub, R; Kida, K; Kimura, Y; Jenkins, P; Martens, JR; Setou, M; Benmerah, A; Blacque, OE,期刊:Journal of cell science, 页码:3966-3977 , 文章类型: Article,,卷期:2010年123-22]
- Clathrin adaptor (AP) complexes facilitate membrane trafficking between subcellular compartments. One such compartment is the cilium, whose dysfunction underlies disorders classified as ciliopathies. Although AP-1mu subu...
- A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells
[作者:Abe, Y; Okumura, E; Hosoya, T; Hirota, T; Kishimoto, T,期刊:Journal of cell science, 页码:3978-3988 , 文章类型: Article,,卷期:2010年123-22]
- Aurora, an essential mitotic kinase, is highly conserved during evolution. Most vertebrates have at least two Aurora kinases, Aurora-A and Aurora-B, which have distinct functions in the centrosome-spindle and inner centr...
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