- Adenosine and Prostaglandin E-2 Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells
[作者:Mandapathil, M; Szczepanski, MJ; Szajnik, M; Ren, J; Jackson, EK; Johnson, JT; Gorelik, E; Lang, S; Whiteside, TL,期刊:Journal of Biological Chemistry, 页码:27571-27580 , 文章类型: Article,,卷期:2010年285-36]
- Adaptive regulatory T cells (Tr1) are induced in the periphery upon encountering cognate antigens. In cancer, their frequency is increased; however, Tr1-mediated suppression mechanisms are not yet defined. Here, we evalu...
- A Novel Pleckstrin Homology Domain-containing Protein Enhances Insulin-stimulated Akt Phosphorylation and GLUT4 Translocation in Adipocytes
[作者:Zhou, QOL; Jiang, ZY; Mabardy, AS; Del Campo, CM; Lambright, DG; Holik, J; Fogarty, KE; Straubhaar, J; Nicoloro, S; Chawla, A; Czech, MP,期刊:Journal of Biological Chemistry, 页码:27581-27589 , 文章类型: Article,,卷期:2010年285-36]
- Protein kinase B/Akt protein kinases control an array of diverse functions, including cell growth, survival, proliferation, and metabolism. We report here the identification of pleckstrin homology-like domain family B me...
- Characterization of the O-antigen Polymerase (Wzy) of Francisella tularensis
[作者:Kim, TH; Sebastian, S; Pinkham, JT; Ross, RA; Blalock, LT; Kasper, DL,期刊:Journal of Biological Chemistry, 页码:27839-27849 , 文章类型: Article,,卷期:2010年285-36]
- The O-antigen polymerase of Gram-negative bacteria has been difficult to characterize. Herein we report the biochemical and functional characterization of the protein product (Wzy) of the gene annotated as the putative O...
- Deciphering the Kinetic Binding Mechanism of Dimeric Ligands Using a Potent Plasma-stable Dimeric Inhibitor of Postsynaptic Density Protein-95 as an Example
[作者:Chi, CN; Bach, A; Gottschalk, M; Kristensen, AS; Stromgaard, K; Jemth, P,期刊:Journal of Biological Chemistry, 页码:28252-28260 , 文章类型: Article,,卷期:2010年285-36]
- Dimeric ligands can be potent inhibitors of protein-protein or enzyme-substrate interactions. They have increased affinity and specificity toward their targets due to their ability to bind two binding sites simultaneousl...
- The Lipid-binding Domain of Wild Type and Mutant alpha-Synuclein COMPACTNESS AND INTERCONVERSION BETWEEN THE BROKEN AND EXTENDED HELIX FORMS
[作者:Georgieva, ER; Ramlall, TF; Borbat, PP; Freed, JH; Eliezer, D,期刊:Journal of Biological Chemistry, 页码:28261-28274 , 文章类型: Article,,卷期:2010年285-36]
- alpha-Synuclein (alpha S) is linked to Parkinson disease through its deposition in an amyloid fibril form within Lewy Body deposits, and by the existence of three alpha S point mutations that lead to early onset autosoma...
- MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment
[作者:Marchese, FP; Aubareda, A; Tudor, C; Saklatvala, J; Clark, AR; Dean, JLE,期刊:Journal of Biological Chemistry, 页码:27590-27600 , 文章类型: Article,,卷期:2010年285-36]
- Tristetraprolin (TTP) directs its target AU-rich element (ARE)-containing mRNAs for degradation by promoting removal of the poly(A) tail. The p38 MAPK pathway regulates mRNA stability via the downstream kinase MAPK-activ...
- Blockade of Dendritic Cell Development by Bacterial Fermentation Products Butyrate and Propionate through a Transporter (Slc5a8)-dependent Inhibition of Histone Deacetylases
[作者:Singh, N; Thangaraju, M; Prasad, PD; Martin, PM; Lambert, NA; Boettger, T; Offermanns, S; Ganapathy, V,期刊:Journal of Biological Chemistry, 页码:27601-27608 , 文章类型: Article,,卷期:2010年285-36]
Mammalian colon harbors trillions of bacteria, yet there is no undue inflammatory response by the host against these bacteria under normal conditions. The bacterial fermentation products acetate, propionate, and butyr...
- Regulation of Sodium-Calcium Exchanger Activity by Creatine Kinase under Energy-compromised Conditions
[作者:Yang, YC; Fann, MJ; Chang, WH; Tai, LH; Jiang, JH; Kao, LS,期刊:Journal of Biological Chemistry, 页码:28275-28285 , 文章类型: Article,,卷期:2010年285-36]
- Na+/Ca2+ exchanger (NCX) is one of the major mechanisms for removing Ca2+ from the cytosol especially in cardiac myocytes and neurons, where their physiological activities are triggered by an influx of Ca2+. NCX contains...
- Role of Mechanical Stress-induced Glutamate Signaling-associated Molecules in Cytodifferentiation of Periodontal Ligament Cells
[作者:Fujihara, C; Yamada, S; Ozaki, N; Takeshita, N; Kawaki, H; Takano-Yamamoto, T; Murakami, S,期刊:Journal of Biological Chemistry, 页码:28286-28297 , 文章类型: Article,,卷期:2010年285-36]
- In this study, we analyzed the effects of tensile mechanical stress on the gene expression profile of in vitro-maintained human periodontal ligament (PDL) cells. A DNA chip analysis identified 17 up-regulated genes in hu...
- A Small Ubiquitin-related Modifier-interacting Motif Functions as the Transcriptional Activation Domain of Kruppel-like Factor 4
[作者:Du, JX; McConnell, BB; Yang, VW,期刊:Journal of Biological Chemistry, 页码:28298-28308 , 文章类型: Article,,卷期:2010年285-36]
- The zinc finger transcription factor, Kruppel-like factor 4 (KLF4), regulates numerous biological processes, including proliferation, differentiation, and embryonic stem cell self-renewal. Although the DNA sequence to wh...
- Identification of the Chromophores Involved in Aggregation-dependent Energy Quenching of the Monomeric Photosystem II Antenna Protein Lhcb5
[作者:Ballottari, M; Girardon, J; Betterle, N; Morosinotto, T; Bassi, R,期刊:Journal of Biological Chemistry, 页码:28309-28321 , 文章类型: Article,,卷期:2010年285-36]
- Non-photochemical quenching (NPQ) of excess absorbed light energy is a fundamental process that regulates photosynthetic light harvesting in higher plants. Among several proposed NPQ mechanisms, aggregation-dependent que...
- Isoform-specific Prolongation of Kv7 (KCNQ) Potassium Channel Opening Mediated by New Molecular Determinants for Drug-Channel Interactions
[作者:Gao, ZB; Zhang, TZ; Wu, M; Xiong, QJ; Sun, HY; Zhang, YA; Zu, LS; Wang, W; Li, M,期刊:Journal of Biological Chemistry, 页码:28322-28332 , 文章类型: Article,,卷期:2010年285-36]
- Kv7 channels, especially Kv7.2 (KCNQ2) and Kv7.3 (KCNQ3), are key determinants for membrane excitability in the brain. Some chemical modulators of KCNQ channels are in development for use as anti-epileptic drugs, such as...
- Negative Regulation of Meiotic Gene Expression by the Nuclear Poly(a)-binding Protein in Fission Yeast
[作者:St-Andre, O; Lemieux, C; Perreault, A; Lackner, DH; Bahler, J; Bachand, F,期刊:Journal of Biological Chemistry, 页码:27859-27868 , 文章类型: Article,,卷期:2010年285-36]
- Meiosis is a cellular differentiation process in which hundreds of genes are temporally induced. Because the expression of meiotic genes during mitosis is detrimental to proliferation, meiotic genes must be negatively re...
- Activation of Na+/H+ Exchanger NHE3 by Angiotensin II Is Mediated by Inositol 1,4,5-Triphosphate (IP3) Receptor-binding Protein Released with IP3 (IRBIT) and Ca2+/Calmodulin-dependent Protein Kinase II
[作者:He, PJ; Klein, J; Yun, CC,期刊:Journal of Biological Chemistry, 页码:27869-27878 , 文章类型: Article,,卷期:2010年285-36]
- Angiotensin II (ANG II) stimulates renal tubular reabsorption of NaCl by targeting Na+/H+ exchanger NHE3. We have shown previously that inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-tr...
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