- Formation of a Ternary Complex among NHERF1, beta-Arrestin, and Parathyroid Hormone Receptor
[作者:Klenk, C; Vetter, T; Zurn, A; Vilardaga, JP; Friedman, PA; Wang, B; Lohse, MJ,期刊:Journal of Biological Chemistry, 页码:30355-30362 , 文章类型: Article,,卷期:2010年285-39]
- beta-Arrestins are crucial regulators of G-protein coupled receptor (GPCR) signaling, desensitization, and internalization. Despite the long-standing paradigm that agonist-promoted receptor phosphorylation is required fo...
- Substrate Binding in Free Methionine-R-sulfoxide Reductase Reply
[作者:Bong, SM; Kwak, GH; Moon, JH; Lee, KS; Kim, HS; Kim, HY; Chi, YM,期刊:Journal of Biological Chemistry, 页码:LE18-LE18 , 文章类型: Letter,,卷期:2010年285-39]
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- A Novel Mechanism Involving Coordinated Regulation of Nuclear Levels and Acetylation of NF-YA and Bcl6 Activates RGS4 Transcription
[作者:Yang, JQ; Huang, J; Chatterjee, TK; Twait, E; Fisher, RA,期刊:Journal of Biological Chemistry, 页码:29760-29769 , 文章类型: Article,,卷期:2010年285-39]
- Neuronally enriched RGS4 plays a critical role attenuating G protein signaling in brain, although the mechanisms regulating RGS4 expression are unknown. Here we describe a novel mechanism for transcriptional activation o...
- Decreased Soluble Adenylyl Cyclase Activity in Cystic Fibrosis Is Related to Defective Apical Bicarbonate Exchange and Affects Ciliary Beat Frequency Regulation
[作者:Schmid, A; Sutto, Z; Schmid, N; Novak, L; Ivonnet, P; Horvath, G; Conner, G; Fregien, N; Salathe, M,期刊:Journal of Biological Chemistry, 页码:29998-30007 , 文章类型: Article,,卷期:2010年285-39]
- Human airway cilia contain soluble adenylyl cyclase (sAC) that produces cAMP upon HCO3-/CO2 stimulation to increase ciliary beat frequency (CBF). Because apical HCO3-exchange depends on cystic fibrosis transmembrane cond...
- Differences in the Interactions between the Subunits of Photosystem II Dependent on D1 Protein Variants in the Thermophilic Cyanobacterium Thermosynechococcus elongatus
[作者:Sugiura, M; Iwai, E; Hayashi, H; Boussac, A,期刊:Journal of Biological Chemistry, 页码:30008-30018 , 文章类型: Article,,卷期:2010年285-39]
- The main cofactors involved in the oxygen evolution activity of Photosystem II (PSII) are located in two proteins, D1 (PsbA) and D2 (PsbD). In Thermosynechococcus elongatus, a thermophilic cyanobacterium, the D1 protein ...
- Kinetic Basis for the Conjugation of Auxin by a GH3 Family Indole-acetic Acid-Amido Synthetase
[作者:Chen, QF; Westfall, CS; Hicks, LM; Wang, SP; Jez, JM,期刊:Journal of Biological Chemistry, 页码:29780-29786 , 文章类型: Article,,卷期:2010年285-39]
- The GH3 family of acyl-acid-amido synthetases catalyze the ATP-dependent formation of amino acid conjugates to modulate levels of active plant hormones, including auxins and jasmonates. Initial biochemical studies of var...
- Adenosine A(2A) Receptor Signaling and G(olf) Assembly Show a Specific Requirement for the gamma(7) Subtype in the Striatum
[作者:Schwindinger, WF; Mihalcik, LJM; Giger, KE; Betz, KS; Stauffer, AM; Linden, J; Herve, D; Robishaw, JD,期刊:Journal of Biological Chemistry, 页码:29787-29796 , 文章类型: Article,,卷期:2010年285-39]
- The adenosine A(2A) receptor (A(2A)R) is increasingly recognized as a novel therapeutic target in Parkinson disease. In striatopallidal neurons, the G-protein alpha(olf) subtype is required to couple this receptor to ade...
- Selective Transport of alpha-Mannosidase by Autophagic Pathways IDENTIFICATION OF A NOVEL RECEPTOR, Atg34p
[作者:Suzuki, K; Kondo, C; Morimoto, M; Ohsumi, Y,期刊:Journal of Biological Chemistry, 页码:30019-30025 , 文章类型: Article,,卷期:2010年285-39]
- In Saccharomyces cerevisiae, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) are known cargoes of selective autophagy. Atg19p has been identified as an Ape1p receptor and targets Ape1p to the preautophagosomal str...
- Selective Transport of alpha-Mannosidase by Autophagic Pathways STRUCTURAL BASIS FOR CARGO RECOGNITION BY Atg19 AND Atg34
[作者:Watanabe, Y; Noda, NN; Kumeta, H; Suzuki, K; Ohsumi, Y; Inagaki, F,期刊:Journal of Biological Chemistry, 页码:30026-30033 , 文章类型: Article,,卷期:2010年285-39]
- In the yeast Saccharomyces cerevisiae, a precursor form of aminopeptidase I (prApe1) and alpha-mannosidase (Ams1) are selectively transported to the vacuole through the cytoplasm-to-vacuole targeting pathway under vegeta...
- Histone Demethylase LSD1 Regulates Adipogenesis
[作者:Musri, MM; Carmona, MC; Hanzu, FA; Kaliman, P; Gomis, R; Parrizas, M,期刊:Journal of Biological Chemistry, 页码:30034-30041 , 文章类型: Article,,卷期:2010年285-39]
- Epigenetic mechanisms, in particular the enzymatic modification of histones, are a crucial element of cell differentiation, a regulated process that allows a precursor cell basically to turn into a different cell type wh...
- E2 Polyubiquitin-conjugating Enzyme Ubc13 in Keratinocytes Is Essential for Epidermal Integrity
[作者:Sayama, K; Yamamoto, M; Shirakata, Y; Hanakawa, Y; Hirakawa, S; Dai, XJ; Tohyama, M; Tokumaru, S; Shin, MS; Sakurai, H; Akira, S; Hashimoto, K,期刊:Journal of Biological Chemistry, 页码:30042-30049 , 文章类型: Article,,卷期:2010年285-39]
- The E2 polyubiquitin-conjugating enzyme Ubc13 is a mediator of innate immune reactions. Ubc13 mediates the conjugation of keratin (K)63-linked polyubiquitin chains onto TNF receptor-associated factor 6 and IKK gamma duri...
- Tetrahydrolipstatin Inhibition, Functional Analyses, and Three-dimensional Structure of a Lipase Essential for Mycobacterial Viability
[作者:Crellin, PK; Vivian, JP; Scoble, J; Chow, FM; West, NP; Brammananth, R; Proellocks, NI; Shahine, A; Le Nours, J; Wilce, MCJ; Britton, WJ; Coppel, RL; Rossjohn, J; Beddoe, T,期刊:Journal of Biological Chemistry, 页码:30050-30060 , 文章类型: Article,,卷期:2010年285-39]
- The highly complex and unique mycobacterial cell wall is critical to the survival of Mycobacteria in host cells. However, the biosynthetic pathways responsible for its synthesis are, in general, incompletely characterize...
- Functional Analysis of the Cucumisin Propeptide as a Potent Inhibitor of Its Mature Enzyme
[作者:Nakagawa, M; Ueyama, M; Tsuruta, H; Uno, T; Kanamaru, K; Mikami, B; Yamagata, H,期刊:Journal of Biological Chemistry, 页码:29797-29807 , 文章类型: Article,,卷期:2010年285-39]
- Cucumisin is a subtilisin-like serine protease (subtilase) that is found in the juice of melon fruits (Cucumis melo L.). It is synthesized as a preproprotein consisting of a signal peptide, NH2-terminal propeptide, and 6...
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