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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共22条记录   Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae [作者：Hohmann, S,期刊：FEBS Letters, 页码：4025-4029 , 文章类型： Proceedings Paper，,卷期：2009年583-24] Signal transduction pathways control cellular responses to extrinsic and intrinsic signals. The yeast HOG (High Osmolarity Glycerol) response pathway mediates cellular adaptation to hyperosmotic stress. Pathway architect... Systems Biology Nobel Symposium 146 Preface [作者：Ehrenberg, M; Elf, J; Hohmann, S,期刊：FEBS Letters, 页码：3881-3881 , 文章类型： Editorial Material，,卷期：2009年583-24] Systems Biology: The elements and principles of Life [作者：Westerhoff, HV; Winder, C; Messiha, H; Simeonidis, E; Adamczyk, M; Verma, M; Bruggeman, FJ; Dunn, W,期刊：FEBS Letters, 页码：3882-3890 , 文章类型： Proceedings Paper，,卷期：2009年583-24] Systems Biology has a mission that puts it at odds with traditional paradigms of physics and molecular biology, such as the simplicity requested by Occam's razor and minimum energy/maximal efficiency. By referring to bio... A unifying view of 21st century systems biology [作者：Vidal, M,期刊：FEBS Letters, 页码：3891-3894 , 文章类型： Proceedings Paper，,卷期：2009年583-24] The idea that multi-scale dynamic complex systems formed by interacting macromolecules and metabolites, cells, organs and organisms underlie some of the most fundamental aspects of life was proposed by a few visionaries ... Systems biology from a yeast omics perspective [作者：Snyder, M; Gallagher, JEG,期刊：FEBS Letters, 页码：3895-3899 , 文章类型： Proceedings Paper，,卷期：2009年583-24] Systems biology represents a paradigm shift from the study of individual genes, proteins or other components to that of the analysis of entire pathways, cellular, developmental, or organismal processes. Large scale studi... Metabolic systems biology [作者：Palsson, B,期刊：FEBS Letters, 页码：3900-3904 , 文章类型： Proceedings Paper，,卷期：2009年583-24] The first full genome sequences were established in the mid-1990s. Shortly thereafter, genome-scale metabolic network reconstructions appeared. Since that time, we have witnessed an exponential growth in their number and... Systems biology of lipid metabolism: From yeast to human [作者：Nielsen, J,期刊：FEBS Letters, 页码：3905-3913 , 文章类型： Proceedings Paper，,卷期：2009年583-24] Lipid metabolism is highly relevant as it plays a central role in a number of human diseases. Due to the highly interactive structure of lipid metabolism and its regulation, it is necessary to apply a holistic approach, ... Qualitatively distinct phenotypes in the design space of biochemical systems [作者：Savageau, MA; Fasani, RA,期刊：FEBS Letters, 页码：3914-3922 , 文章类型： Proceedings Paper，,卷期：2009年583-24] Although characterization of the genotype has undergone revolutionary advances as a result of the successful genome projects, the chasm between our understanding of a fully characterized gene sequence and the phenotypic ... Systems analysis of cellular networks under uncertainty [作者：Kaltenbach, HM; Dimopoulos, S; Stelling, J,期刊：FEBS Letters, 页码：3923-3930 , 文章类型： Proceedings Paper，,卷期：2009年583-24] Besides the often-quoted complexity of cellular networks, the prevalence of uncertainties about components, interactions, and their quantitative features provides a largely underestimated hallmark of current systems biol... The pedestrian watchmaker: Genetic clocks from engineered oscillators [作者：Cookson, NA; Tsimring, LS; Hasty, J,期刊：FEBS Letters, 页码：3931-3937 , 文章类型： Proceedings Paper，,卷期：2009年583-24] The crucial role of time-keeping has required organisms to develop sophisticated regulatory networks to ensure the reliable propagation of periodic behavior. These biological clocks have long been a focus of research; ho... The molecular clockwork of a protein-based circadian oscillator [作者：Markson, JS; O'Shea, EK,期刊：FEBS Letters, 页码：3938-3947 , 文章类型： Proceedings Paper，,卷期：2009年583-24] The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is governed by a core oscillator consisting of the proteins KaiA, KaiB, and KaiC. Remarkably, circadian oscillations in the phosphorylation state... Modularity and design principles in the sea urchin embryo gene regulatory network [作者：Peter, IS; Davidson, EH,期刊：FEBS Letters, 页码：3948-3958 , 文章类型： Proceedings Paper，,卷期：2009年583-24] The gene regulatory network (GRN) established experimentally for the pre-gastrular sea urchin embryo provides causal explanations of the biological functions required for spatial specification of embryonic regulatory sta... Fungal regulatory evolution: cis and trans in the balance [作者：Thompson, DA; Regev, A,期刊：FEBS Letters, 页码：3959-3965 , 文章类型： Proceedings Paper，,卷期：2009年583-24] Regulatory divergence is likely a major driving force in evolution. Comparative genomics is being increasingly used to infer the evolution of gene regulation. Ascomycota fungi are uniquely suited among eukaryotes for reg... Correlation of mRNA and protein in complex biological samples [作者：Maier, T; Guell, M; Serrano, L,期刊：FEBS Letters, 页码：3966-3973 , 文章类型： Proceedings Paper，,卷期：2009年583-24] The correlation between mRNA and protein abundances in the cell has been reported to be notoriously poor. Recent technological advances in the quantitative analysis of mRNA and protein species in complex samples allow th... Coordination of gene expression with growth rate: A feedback or a feed-forward strategy? [作者：Levy, S; Barkai, N,期刊：FEBS Letters, 页码：3974-3978 , 文章类型： Proceedings Paper，,卷期：2009年583-24] In the budding yeast, a large fraction of genes is coordinately regulated with growth rate. We argue that this correlation does not reflect a direct feedback from growth rate to gene expression. Rather, what appears to b... Single molecule approaches to transcription factor kinetics in living cells [作者：Li, GW; Elf, J,期刊：FEBS Letters, 页码：3979-3983 , 文章类型： Proceedings Paper，,卷期：2009年583-24] Quantitative modeling of intracellular processes often requires information about intracellular rate constants as well as the concentrations of low abundance species in individual cells. Single molecule imaging technique...