- MCP-induced protein 1 suppresses TNF alpha-induced VCAM-1 expression in human endothelial cells
[作者:Qi, YF; Liang, JA; She, ZG; Cai, Y; Wang, J; Lei, TH; Stallcup, WB; Fu, MG,期刊:FEBS Letters, 页码:3065-3072 , 文章类型: Article,,卷期:2010年584-14]
- Endothelial inflammation plays a critical role in the development and progression of cardiovascular disease, albeit the mechanisms need to be fully elucidated. We here report that treatment of human umbilical vein endoth...
- Glucose is necessary for stabilization of hypoxia-inducible factor-1 alpha under hypoxia: Contribution of the pentose phosphate pathway to this stabilization
[作者:Osada-Oka, M; Hashiba, Y; Akiba, S; Imaoka, S; Sato, T,期刊:FEBS Letters, 页码:3073-3079 , 文章类型: Article,,卷期:2010年584-14]
- In this study, we observed that low glucose or fructose reduces the increase in hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein under hypoxic conditions. 6-Aminonicotinamide (6-AN), an inhibitor of the pentose pho...
- Role of hepatocyte nuclear factor-4 alpha in transcriptional regulation of C1qTNF-related protein 5 in the liver
[作者:Kim, MJ; Lee, W; Park, EJ; Park, SY,期刊:FEBS Letters, 页码:3080-3084 , 文章类型: Article,,卷期:2010年584-14]
- Recently, we found that C1qTNF-related protein 5 (CTRP5) is involved in glucose and lipid metabolism. However, the transcriptional regulation of CTRP5 is largely unknown. Here we demonstrate the mechanism by which the CT...
- Biochemical characterization of a novel ArsA ATPase complex from Alkaliphilus metalliredigens QYMF
[作者:Fu, HL; Rosen, BP; Bhattacharjee, H,期刊:FEBS Letters, 页码:3089-3094 , 文章类型: Article,,卷期:2010年584-14]
- The two putative ars operons in Alkaliphilus metalliredigens QYMF are distinctive in that the arsA gene is split in halves, amarsA1 and amarsA2, and, acr3 but not an arsB gene coexists with arsA. Heterologous expression ...
- Alterations of the Wnt/beta-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice
[作者:Portal-Nunez, S; Lozano, D; de Castro, LF; de Gortazar, AR; Nogues, X; Esbrit, P,期刊:FEBS Letters, 页码:3095-3100 , 文章类型: Article,,卷期:2010年584-14]
- Type 1 diabetes mellitus (T1D) is associated with bone loss. Given that the Wnt/beta-catenin pathway is a major regulator of bone accrual, we assessed this pathway in mice with streptozotozin-induced T1D. In diabetic mou...
- Starvation triggers A beta(42) generation from human umbilical vascular endothelial cells
[作者:Ma, JF; Wang, HM; Li, QY; Zhang, Y; Pan, J; Qiang, Q; Xin, XY; Tang, HD; Ding, JQ; Chen, SD,期刊:FEBS Letters, 页码:3101-3106 , 文章类型: Article,,卷期:2010年584-14]
- Cerebral amyloid angiopathy is a common feature in Alzheimer's disease (AD), which is characterized by amyloid deposit around brain vessels including capillaries. The origin of the amyloid protein of CAA remains controve...
- Acid-sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification
[作者:Yokokawa, M; Carnally, SM; Henderson, RM; Takeyasu, K; Edwardson, JM,期刊:FEBS Letters, 页码:3107-3110 , 文章类型: Article,,卷期:2010年584-14]
- The acid-sensing ion channel (ASIC) 1a is known to assemble as a homotrimer. Here, we used atomic force microscopy to image ASIC1a, integrated into lipid bilayers, at pH 7.0 and pH 6.0. The triangular appearance of the c...
- Glucose and lactate regulate maitotoxin-activated Ca2+ entry in spermatogenic cells: The role of intracellular [Ca2+]
[作者:Reyes, JG; Osses, N; Knox, M; Darszon, A; Trevino, CL,期刊:FEBS Letters, 页码:3111-3115 , 文章类型: Article,,卷期:2010年584-14]
- Maitotoxin (MTX), a potent polyether marine biotoxin, induces Ca2+ entry in different mammalian cells by activation of Ca2+ channels. The identity and modulation of the MTX-activated Ca2+ entry pathway is not known. In t...
- Weird fingers: Functional analysis of WIP domain proteins
[作者:Appelhagen, I; Huep, G; Lu, GH; Strompen, G; Weisshaar, B; Sagasser, M,期刊:FEBS Letters, 页码:3116-3122 , 文章类型: Article,,卷期:2010年584-14]
- WIP proteins form a plant specific subfamily of C2H2 zinc finger (ZF) proteins. In this study, we functionally characterized the WIP domain, which consists of four ZF motifs, and discuss molecular functions for WIP prote...
- Activation of retinoic acid receptor signaling coordinates lineage commitment of spontaneously differentiating mouse embryonic stem cells in embryoid bodies
[作者:Simandi, Z; Balint, BL; Poliska, S; Ruhl, R; Nagy, L,期刊:FEBS Letters, 页码:3123-3130 , 文章类型: Article,,卷期:2010年584-14]
- Retinoid signaling has been implicated in embryonic stem cell differentiation. Here we present a systematic analysis of gene expression changes in mouse embryonic stem cells (mESCs), during their spontaneous differentiat...
- Biochemical characterisation of Murray Valley encephalitis virus proteinase
[作者:Joy, J; Mee, NF; Kuan, WL; Perlyn, KZ; Wen, TS; Hill, J,期刊:FEBS Letters, 页码:3149-3152 , 文章类型: Article,,卷期:2010年584-14]
- Murray Valley encephalitis virus (MVEV) is a member of the flavivirus group, a large family of single stranded RNA viruses, which cause serious disease in all regions of the world. Its genome encodes a large polyprotein ...
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