- A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease
[作者:Pfeffer, MA; Burdmann, EA; Chen, CY; Cooper, ME; de Zeeuw, D; Eckardt, KU; Feyzi, JM; Ivanovich, P; Kewalramani, R; Levey, AS; Lewis, EF; McGill, JB; McMurray, JJV; Parfrey, P; Parving, HH; Remuzzi, G; Singh, AK; Solomon, SD; Toto, R,期刊:New England Journal of Medicine, 页码:2019-2032 , 文章类型: Article,,卷期:2009年361-21]
- BACKGROUNDAnemia is associated with an increased risk of cardiovascular and renal events among patients with type 2 diabetes and chronic kidney disease. Although darbepoetin alfa can effectively increase hemoglobin level...
- Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
[作者:Glocker, EO; Kotlarz, D; Boztug, K; Gertz, EM; Schaffer, AA; Noyan, F; Perro, M; Diestelhorst, J; Allroth, A; Murugan, D; Hatscher, N; Pfeifer, D; Sykora, KW; Sauer, M; Kreipe, H; Lacher, M; Nustede, R; Woellner, C; Baumann, U; Salzer, U; Koletzko, S; Shah, N; Segal, AW; Sauerbrey, A; Buderus, S; Snapper, SB; Grimbacher, B; Klein, C,期刊:New England Journal of Medicine, 页码:2033-2045 , 文章类型: Article,,卷期:2009年361-21]
- BACKGROUNDThe molecular cause of inflammatory bowel disease is largely unknown.METHODSWe performed genetic-linkage analysis and candidate-gene sequencing on samples from two unrelated consanguineous families with childre...
- Combined Immunodeficiency Associated with DOCK8 Mutations
[作者:Zhang, Q; Davis, JC; Lamborn, IT; Freeman, AF; Jing, H; Favreau, AJ; Matthews, HF; Davis, J; Turner, ML; Uzel, G; Holland, SM; Su, HC,期刊:New England Journal of Medicine, 页码:2046-2055 , 文章类型: Article,,卷期:2009年361-21]
- BACKGROUNDRecurrent sinopulmonary and cutaneous viral infections with elevated serum levels of IgE are features of some variants of combined immunodeficiency. The genetic causes of these variants are unknown.METHODSWe co...
- A Novel Protective Prion Protein Variant that Colocalizes with Kuru Exposure
[作者:Mead, S; Whitfield, J; Poulter, M; Shah, P; Uphill, J; Campbell, T; Al-Dujaily, H; Hummerich, H; Beck, J; Mein, CA; Verzilli, C; Whittaker, J; Alpers, MP; Collinge, J,期刊:New England Journal of Medicine, 页码:2056-2065 , 文章类型: Article,,卷期:2009年361-21]
- BACKGROUNDKuru is a devastating epidemic prion disease that affected a highly restricted geographic area of the Papua New Guinea highlands; at its peak, it predominantly affected adult women and children of both sexes. I...
- A Man with Cough, Hoarseness, and Abnormalities on Chest Imaging Ewing's sarcoma of the bone, with metastasis to the lung and mediastinal lymph nodes.
[作者:Choy, E; Digumarthy, SR; Koplin, SA,期刊:New England Journal of Medicine, 页码:2080-2087 , 文章类型: Article,,卷期:2009年361-21]
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